IMPC phenotypes (gene matching)
B6.129P2-B2mtm1Unc/Orl
| Status | Available to order |
| EMMA ID | EM:00029 |
| Citation information | RRID:IMSR_EM:00029 Research Resource Identifiers (RRID) are persistent unique ID numbers assigned to help researchers cite key resources (e.g. antibodies, model organisms and software projects) in the biomedical literature to improve transparency and reproducibility in research. See https://www.rrids.org/ for more information. |
| International strain name | B6.129P2-B2mtm1Unc/Orl |
| Alternative name | beta2m° |
| Strain type | Targeted Mutant Strains : Knock-out |
| Allele/Transgene symbol | B2mtm1Unc |
| Gene/Transgene symbol | B2m |
Information from provider
| Provider | Beverly H. Koller |
| Provider affiliation | c/o CDTA-Orleans |
| Phenotypic information | The B2M protein is linked to MHC class I molecules. The mutant mice carry a null mutation in the beta-2 microglobulin (B2m) gene. Obtained by mutation of the B2m gene by homologous recombination (insertion of neomycin-resistance gene). Class I molecules are lacking or unstable on the cell surface, leading to a nearly elimination of the T CD8+ compartment. Cytotoxic immune responses are much altered. |
| Breeding history | 129P2/OlaHsd ES cells; 9 generations of backcross to C57BL/6, then intercross. |
| References |
|
Information from EMMA
| Archiving centre | Institut de Transgenose, INTRAGENE, Orléans, France |
Disease and phenotype information
Orphanet associated rare diseases, based on orthologous gene matching
- Immunodeficiency by defective expression of MHC class I / Orphanet_34592
- Variant ABeta2M amyloidosis / Orphanet_314652
MGI phenotypes (allele matching)
- decreased level of surface class I molecules / MGI
- decreased CD8-positive, alpha-beta T cell number / MGI
- decreased IgG level / MGI
- abnormal pancreas morphology / MGI
- decreased susceptibility to bacterial infection / MGI
- increased IgM level / MGI
- decreased susceptibility to autoimmune diabetes / MGI
- decreased circulating serum albumin level / MGI
- increased T-helper 1 cell number / MGI
- abnormal interleukin level / MGI
- abnormal tumor necrosis factor level / MGI
- increased susceptibility to infection induced morbidity/mortality / MGI
- absent CD8-positive, alpha-beta T cells / MGI
- abnormal pancreatic beta cell morphology / MGI
- abnormal T cell number / MGI
- insulitis / MGI
MGI phenotypes (gene matching)
- absent CD8-positive, alpha-beta T cells / MGI
- decreased IgG level / MGI
- decreased level of surface class I molecules / MGI
- abnormal pancreas morphology / MGI
- decreased susceptibility to bacterial infection / MGI
- abnormal CD8-positive, alpha-beta cytotoxic T cell morphology / MGI
- increased IgM level / MGI
- insulitis / MGI
- abnormal lateral geniculate nucleus morphology / MGI
- decreased susceptibility to autoimmune diabetes / MGI
- decreased susceptibility to parasitic infection / MGI
- abnormal cytotoxic T cell physiology / MGI
- abnormal pancreatic beta cell morphology / MGI
- decreased circulating serum albumin level / MGI
- hemochromatosis / MGI
- abnormal T cell number / MGI
- decreased CD8-positive, alpha-beta T cell number / MGI
- increased T-helper 1 cell number / MGI
- increased gamma-delta T cell number / MGI
- increased gamma-delta intraepithelial T cell number / MGI
- increased tumor necrosis factor secretion / MGI
- increased interleukin-3 secretion / MGI
- decreased interleukin-4 secretion / MGI
- abnormal interleukin level / MGI
- abnormal tumor necrosis factor level / MGI
- increased susceptibility to infection induced morbidity/mortality / MGI
Literature references
- Normal development of mice deficient in beta 2M, MHC class I proteins, and CD8+ T cells.;Koller B H, Marrack P, Kappler J W, Smithies O, ;1990;Science (New York, N.Y.);248;1227-30; 2112266