129/Sv-Vax1tm1Pgr/PgrCnrm
Status | Available to order |
EMMA ID | EM:00274 |
International strain name | 129/Sv-Vax1tm1Pgr/PgrCnrm |
Alternative name | Vax1 |
Strain type | Targeted Mutant Strains : Knock-out |
Allele/Transgene symbol | Vax1tm1Pgr |
Gene/Transgene symbol | Vax1 |
Information from provider
Provider | Peter Gruss |
Provider affiliation | Max Planck Inst. Biophysical Chemistry |
Genetic information | 6.2 kb 5-prime Vax1 genomic fragment, beta galactosidase, 8.5 kb 3-prime Vax1 genomic fragment |
Phenotypic information | Defects in basal forebrain and optic nerve development (see Hallonet et al., 1999). Model of optic nerve coloboma. |
References |
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Information from EMMA
Archiving centre | CNR, Consiglio Nazionale delle Ricerche, Monterotondo, Italy |
Disease and phenotype information
IMPC phenotypes (gene matching)
MGI phenotypes (allele matching)
- cleft palate / MGI
- abnormal corpus callosum morphology / MGI
- abnormal hypothalamus morphology / MGI
- abnormal telencephalon development / MGI
- abnormal optic nerve morphology / MGI
- abnormal optic nerve innervation / MGI
- premature death / MGI
- abnormal forebrain development / MGI
- holoprosencephaly / MGI
- coloboma / MGI
- abnormal anterior commissure morphology / MGI
- absent optic chiasm / MGI
- lethality at weaning, incomplete penetrance / MGI
- perinatal lethality, incomplete penetrance / MGI
- abnormal upper incisor morphology / MGI
- fused upper incisors / MGI
MGI phenotypes (gene matching)
- cleft palate / MGI
- abnormal corpus callosum morphology / MGI
- abnormal olfactory bulb morphology / MGI
- abnormal hypothalamus morphology / MGI
- abnormal telencephalon development / MGI
- abnormal eye development / MGI
- abnormal optic nerve morphology / MGI
- abnormal optic nerve innervation / MGI
- premature death / MGI
- absent corpus callosum / MGI
- abnormal ependyma morphology / MGI
- abnormal olfactory bulb development / MGI
- abnormal axon guidance / MGI
- abnormal forebrain development / MGI
- abnormal postnatal subventricular zone morphology / MGI
- abnormal lateral ganglionic eminence morphology / MGI
- abnormal rostral migratory stream morphology / MGI
- holoprosencephaly / MGI
- coloboma / MGI
- abnormal anterior commissure morphology / MGI
- absent optic chiasm / MGI
- abnormal neuron differentiation / MGI
- lethality at weaning, incomplete penetrance / MGI
- neonatal lethality, incomplete penetrance / MGI
- perinatal lethality, incomplete penetrance / MGI
- abnormal upper incisor morphology / MGI
- fused upper incisors / MGI
Literature references
- Vax1, a novel homeobox-containing gene, directs development of the basal forebrain and visual system.;Hallonet M, Hollemann T, Pieler T, Gruss P, ;1999;Genes & development;13;3106-14; 10601036
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