IMPC phenotypes (gene matching)
129/Sv-Vax1tm1Pgr/PgrCnrm
| Status | Under development - register interest |
| EMMA ID | EM:00274 |
| Citation information | RRID:IMSR_EM:00274 Research Resource Identifiers (RRID) are persistent unique ID numbers assigned to help researchers cite key resources (e.g. antibodies, model organisms and software projects) in the biomedical literature to improve transparency and reproducibility in research. See https://www.rrids.org/ for more information. |
| International strain name | 129/Sv-Vax1tm1Pgr/PgrCnrm |
| Alternative name | Vax1 |
| Strain type | Targeted Mutant Strains : Knock-out |
| Allele/Transgene symbol | Vax1tm1Pgr |
| Gene/Transgene symbol | Vax1 |
Information from provider
| Provider | Peter Gruss |
| Provider affiliation | Max Planck Inst. Biophysical Chemistry |
| Genetic information | 6.2 kb 5-prime Vax1 genomic fragment, beta galactosidase, 8.5 kb 3-prime Vax1 genomic fragment |
| Phenotypic information | Defects in basal forebrain and optic nerve development (see Hallonet et al., 1999). Model of optic nerve coloboma. |
| References |
|
Information from EMMA
| Archiving centre | CNR, Consiglio Nazionale delle Ricerche, Monterotondo, Italy |
Disease and phenotype information
MGI phenotypes (allele matching)
- cleft palate / MGI
- abnormal corpus callosum morphology / MGI
- abnormal hypothalamus morphology / MGI
- abnormal telencephalon development / MGI
- abnormal optic nerve morphology / MGI
- abnormal optic nerve innervation / MGI
- premature death / MGI
- abnormal forebrain development / MGI
- holoprosencephaly / MGI
- coloboma / MGI
- abnormal anterior commissure morphology / MGI
- absent optic chiasm / MGI
- lethality at weaning, incomplete penetrance / MGI
- perinatal lethality, incomplete penetrance / MGI
- abnormal upper incisor morphology / MGI
- fused upper incisors / MGI
MGI phenotypes (gene matching)
- cleft palate / MGI
- abnormal corpus callosum morphology / MGI
- abnormal olfactory bulb morphology / MGI
- abnormal hypothalamus morphology / MGI
- abnormal telencephalon development / MGI
- abnormal eye development / MGI
- abnormal optic nerve morphology / MGI
- abnormal optic nerve innervation / MGI
- premature death / MGI
- absent corpus callosum / MGI
- abnormal ependyma morphology / MGI
- abnormal olfactory bulb development / MGI
- abnormal axon guidance / MGI
- abnormal forebrain development / MGI
- abnormal postnatal subventricular zone morphology / MGI
- abnormal lateral ganglionic eminence morphology / MGI
- abnormal rostral migratory stream morphology / MGI
- holoprosencephaly / MGI
- coloboma / MGI
- abnormal anterior commissure morphology / MGI
- absent optic chiasm / MGI
- abnormal neuron differentiation / MGI
- lethality at weaning, incomplete penetrance / MGI
- neonatal lethality, incomplete penetrance / MGI
- perinatal lethality, incomplete penetrance / MGI
- abnormal upper incisor morphology / MGI
- fused upper incisors / MGI
Literature references
- Vax1, a novel homeobox-containing gene, directs development of the basal forebrain and visual system.;Hallonet M, Hollemann T, Pieler T, Gruss P, ;1999;Genes & development;13;3106-14; 10601036