MGI phenotypes (allele matching)
B6;129S-Il1rl1tm1Brl/ZbzCnrm
| Status | Available to order |
| EMMA ID | EM:00027 |
| Citation information | RRID:IMSR_EM:00027 Research Resource Identifiers (RRID) are persistent unique ID numbers assigned to help researchers cite key resources (e.g. antibodies, model organisms and software projects) in the biomedical literature to improve transparency and reproducibility in research. See https://www.rrids.org/ for more information. |
| International strain name | B6;129S-Il1rl1tm1Brl/ZbzCnrm |
| Alternative name | B6TgH(GS-T1)Brl |
| Strain type | Targeted Mutant Strains : Knock-out |
| Allele/Transgene symbol | Il1rl1tm1Brl |
| Gene/Transgene symbol | Il1rl1 |
Information from provider
| Provider | Karin Senn |
| Provider affiliation | Institute of Experimental Immunology, Institute of Experimental Immunology |
| Genetic information | Deletion of Il1rl1 (T1/ST2) gene; mice express the lacZ gene under the T1/ST2 promoter. |
| Phenotypic information | For mast cells and T helper 2 (Th2) cells no phenotypic alterations found so far, functional properties under investigation. |
| Breeding history | Chimeric males were bred to C57BL/6 females. Heterozygous animals were bred among each other and different lines were generated maintaining the homozygous Il1rl1-deficient status. |
| References |
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Information from EMMA
| Archiving centre | CNR, Consiglio Nazionale delle Ricerche, Monterotondo, Italy |
Disease and phenotype information
MGI phenotypes (gene matching)
- no abnormal phenotype detected / MGI
- abnormal eosinophil physiology / MGI
- decreased IgE level / MGI
- granulomatous inflammation / MGI
- increased susceptibility to induced pancreatitis / MGI
- increased eosinophil cell number / MGI
- decreased eosinophil cell number / MGI
- abnormal response to infection / MGI
- abnormal T-helper 2 physiology / MGI
- abnormal interleukin secretion / MGI
- decreased interleukin-4 secretion / MGI
- decreased interleukin-5 secretion / MGI
Literature references
- T1-deficient and T1-Fc-transgenic mice develop a normal protective Th2-type immune response following infection with Nippostrongylus brasiliensis.;Senn K A, McCoy K D, Maloy K J, Stark G, Fröhli E, Rülicke T, Klemenz R, ;2000;European journal of immunology;30;1929-38; 10940882