B6;129S-Il1rl1tm1Brl/ZbzCnrm
Status | Available to order |
EMMA ID | EM:00027 |
International strain name | B6;129S-Il1rl1tm1Brl/ZbzCnrm |
Alternative name | B6TgH(GS-T1)Brl |
Strain type | Targeted Mutant Strains : Knock-out |
Allele/Transgene symbol | Il1rl1tm1Brl |
Gene/Transgene symbol | Il1rl1 |
Information from provider
Provider | Karin Senn |
Provider affiliation | Institute of Experimental Immunology, Institute of Experimental Immunology |
Genetic information | Deletion of Il1rl1 (T1/ST2) gene; mice express the lacZ gene under the T1/ST2 promoter. |
Phenotypic information | For mast cells and T helper 2 (Th2) cells no phenotypic alterations found so far, functional properties under investigation. |
Breeding history | Chimeric males were bred to C57BL/6 females. Heterozygous animals were bred among each other and different lines were generated maintaining the homozygous Il1rl1-deficient status. |
References |
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Information from EMMA
Archiving centre | CNR, Consiglio Nazionale delle Ricerche, Monterotondo, Italy |
Disease and phenotype information
MGI phenotypes (allele matching)
MGI phenotypes (gene matching)
- no abnormal phenotype detected / MGI
- abnormal eosinophil physiology / MGI
- decreased IgE level / MGI
- granulomatous inflammation / MGI
- increased susceptibility to induced pancreatitis / MGI
- increased eosinophil cell number / MGI
- decreased eosinophil cell number / MGI
- abnormal response to infection / MGI
- abnormal T-helper 2 physiology / MGI
- abnormal interleukin secretion / MGI
- decreased interleukin-4 secretion / MGI
- decreased interleukin-5 secretion / MGI
Literature references
- T1-deficient and T1-Fc-transgenic mice develop a normal protective Th2-type immune response following infection with Nippostrongylus brasiliensis.;Senn K A, McCoy K D, Maloy K J, Stark G, Fröhli E, Rülicke T, Klemenz R, ;2000;European journal of immunology;30;1929-38; 10940882
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