STOCK Gtf2itm1Vcam/Cnbc

Status

Available to order

EMMA IDEM:02617
Citation informationRRID:IMSR_EM:02617 

Research Resource Identifiers (RRID) are persistent unique ID numbers assigned to help researchers cite key resources (e.g. antibodies, model organisms and software projects) in the biomedical literature to improve transparency and reproducibility in research. See https://www.rrids.org/ for more information.

 
International strain nameSTOCK Gtf2itm1Vcam/Cnbc
Alternative nameGTF2I-2loxP
Strain typeTargeted Mutant Strains : Knock-out
Allele/Transgene symbolGtf2itm1Vcam
Gene/Transgene symbolGtf2i

Information from provider

ProviderVictoria Campuzano
Provider affiliationGENETIC UNIT, CEXS, UNIVERSITAT POMPEU FABRA
Genetic informationTargeting construct is derived from 129 DNA. The deletion spans part of intron 1, exon 2 with start codon ATG, and part of intron 2.
Phenotypic informationSensitive to high sounds. Special facial morphology. Partial viability and fertility of homozygous mutants.
References
  • Essential role of the N-terminal region of TFII-I in viability and behavior.;Lucena Jaume, Pezzi Susana, Aso Ester, Valero Maria C, Carreiro Candelas, Dubus Pierre, Sampaio Adriana, Segura Maria, Barthelemy Isabel, Zindel Marc Y, Sousa Nuno, Barbero José L, Maldonado Rafael, Pérez-Jurado Luis A, Campuzano Victoria, ;2010;BMC medical genetics;11;61; 20403157
Homozygous fertileyes
Homozygous viableyes
Homozygous matings requiredno
Immunocompromisedno

Information from EMMA

Archiving centreCNB-CSIC, Centro Nacional de Biotecnologia, Madrid, Spain
Animals used for archivingheterozygous CD-1 outbred stock (syn.: outbr. CD-1 or CD1, Swiss CD-1 or CD1, ICR(CD-1), etc.) males, wild-type CD-1 outbred stock (syn.: outbr. CD-1 or CD1, Swiss CD-1 or CD1, ICR(CD-1), etc.) females
Stage of embryos8-cell

Disease and phenotype information

MGI allele-associated human disease models

MGI phenotypes (allele matching)
  • increased anxiety-related response / MGI
  • decreased exploration in new environment / MGI
  • decreased vertical activity / MGI
  • abnormal behavior / MGI
  • behavior/neurological phenotype / MGI
  • abnormal craniofacial morphology / MGI
  • short snout / MGI
  • broad nasal bridge / MGI
  • small testis / MGI
  • abnormal embryo development / MGI
  • reduced male fertility / MGI
  • reduced female fertility / MGI
  • testicular atrophy / MGI
  • nervous system phenotype / MGI
  • prenatal lethality, incomplete penetrance / MGI
  • embryonic lethality, incomplete penetrance / MGI
  • absent embryonic epiblast / MGI
  • decreased embryonic epiblast cell proliferation / MGI
MGI phenotypes (gene matching)
  • midline facial cleft / MGI
  • distended pericardium / MGI
  • abnormal craniofacial morphology / MGI
  • short snout / MGI
  • broad nasal bridge / MGI
  • abnormal brain development / MGI
  • exencephaly / MGI
  • small testis / MGI
  • decreased body size / MGI
  • increased anxiety-related response / MGI
  • decreased exploration in new environment / MGI
  • internal hemorrhage / MGI
  • abnormal embryo development / MGI
  • decreased embryo size / MGI
  • reduced male fertility / MGI
  • reduced female fertility / MGI
  • no abnormal phenotype detected / MGI
  • decreased vertical activity / MGI
  • no phenotypic analysis / MGI
  • testicular atrophy / MGI
  • nervous system phenotype / MGI
  • narrow head / MGI
  • pharyngeal arch hypoplasia / MGI
  • embryonic growth retardation / MGI
  • failure of heart looping / MGI
  • dilated allantois / MGI
  • abnormal behavior / MGI
  • behavior/neurological phenotype / MGI
  • failure of chorioallantoic fusion / MGI
  • embryonic lethality, complete penetrance / MGI
  • embryonic lethality during organogenesis, complete penetrance / MGI
  • prenatal lethality, incomplete penetrance / MGI
  • embryonic lethality, incomplete penetrance / MGI
  • absent embryonic epiblast / MGI
  • decreased embryonic epiblast cell proliferation / MGI

Literature references

  • Essential role of the N-terminal region of TFII-I in viability and behavior.;Lucena Jaume, Pezzi Susana, Aso Ester, Valero Maria C, Carreiro Candelas, Dubus Pierre, Sampaio Adriana, Segura Maria, Barthelemy Isabel, Zindel Marc Y, Sousa Nuno, Barbero José L, Maldonado Rafael, Pérez-Jurado Luis A, Campuzano Victoria, ;2010;BMC medical genetics;11;61; 20403157

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