B6;129-Scn10atm3(cre/ERT2)Jwo/H

Status

Available to order

EMMA IDEM:02603
Citation informationRRID:IMSR_EM:02603 

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International strain nameB6;129-Scn10atm3(cre/ERT2)Jwo/H
Alternative nameNav1.8-CreERT2
Strain typeTargeted Mutant Strains : Knock-in
Allele/Transgene symbolScn10atm3(cre/ERT2)Jwo
Gene/Transgene symbolScn10a

Information from provider

ProviderJohn Wood
Provider affiliationUniversity College Lonodon
Genetic informationThe creERT2 gene was inserted at the endogenous ATG start site of the mouse Scn10a (Nav1.8) gene. This strain expresses the tamoxifen-inducible creERT2 recombinase in Scn10a (Nav1.8)-positive neurons in dorsal root ganglia.
Phenotypic informationNone observed. Heterozygous Scn10a (Nav1.8)-creERT2 can express enough cre recombinase to delete the floxed fragment, but it does not affect the expression of Scn10a in Scn10a-positive neurons in dorsal root ganglion.
Breeding historyMostly C57BL/6; between 3-4 crossings to C57BL/6.
References
  • Tamoxifen-inducible NaV1.8-CreERT2 recombinase activity in nociceptive neurons of dorsal root ganglia.;Zhao Jing, Nassar Mohammed A, Gavazzi Isabella, Wood John N, ;2006;Genesis (New York, N.Y. : 2000);44;364-71; 16850455
Homozygous fertileyes
Homozygous viableyes
Homozygous matings requiredno
Immunocompromisedno

Information from EMMA

Archiving centreMary Lyon Centre at MRC Harwell, Oxford, United Kingdom
Animals used for archivingheterozygous C57BL/6 males
Breeding at archiving centreMales were archived upon arrival at the archiving centre. No breeding was performed.

Disease and phenotype information

Orphanet associated rare diseases, based on orthologous gene matching

MGI phenotypes (gene matching)
  • abnormal tail movements / MGI
  • abnormal posture / MGI
  • impaired righting response / MGI
  • apnea / MGI
  • abnormal pain threshold / MGI
  • abnormal nervous system electrophysiology / MGI
  • impaired ability to fire action potentials / MGI
  • abnormal thermal nociception / MGI
  • abnormal mechanical nociception / MGI
  • catalepsy / MGI
  • hypoalgesia / MGI
  • abnormal single cell response / MGI
  • decreased thermal nociceptive threshold / MGI
  • abnormal brain wave pattern / MGI
  • behavior/neurological phenotype / MGI
  • abnormal action potential / MGI
  • hyperalgesia / MGI
  • abnormal RR interval / MGI
  • sinus bradycardia / MGI

Literature references

  • Tamoxifen-inducible NaV1.8-CreERT2 recombinase activity in nociceptive neurons of dorsal root ganglia.;Zhao Jing, Nassar Mohammed A, Gavazzi Isabella, Wood John N, ;2006;Genesis (New York, N.Y. : 2000);44;364-71; 16850455

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Availabilities

Requesting frozen sperm or embryos is generally advisable wherever possible, in order to minimise the shipment of live mice.

  • Frozen sperm. Delivered in 4 weeks (after paperwork in place). €1740*
  • Rederivation of mice from frozen stock, delivery time available upon request . €3880*
  • Tissue - Types of tissue, service fee and delivery time available upon request

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