B6.Cg-Tg(tetO-Gja1,-EGFP)L11Kwi/Cnrm
| Status | Available to order |
| EMMA ID | EM:02594 |
| International strain name | B6.Cg-Tg(tetO-Gja1,-EGFP)L11Kwi/Cnrm |
| Alternative name | Cx43tetOeGFP |
| Strain type | Transgenic Strains |
| Allele/Transgene symbol | Tg(tetO-Gja1,-EGFP)L11Kwi |
| Gene/Transgene symbol | Tg(tetO-Gja1,-EGFP)L11Kwi |
Information from provider
| Provider | Klaus WILLECKE |
| Provider affiliation | Molekulargenetik, Institut fuer Genetik, Universitaet Bonn |
| Genetic information | The transgene contains a bidirectional tetracycline responsive promoter flanked on one side by the Cx43 (Gja1) coding region and on the other side by the eGFP coding region. Expression of a tetracycline transactivator leads to the expression of Cx43 and eGFP, respectively. |
| Phenotypic information | No obvious phenotype could be detected. |
| Breeding history | Founder animals were backcrossed to C57BL/6 more than five times. |
| References |
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| Homozygous fertile | not known |
| Homozygous viable | not known |
| Homozygous matings required | not known |
| Immunocompromised | not known |
Information from EMMA
| Archiving centre | CNR, Consiglio Nazionale delle Ricerche, Monterotondo, Italy |
Literature references
- Engraftment of connexin 43-expressing cells prevents post-infarct arrhythmia.;Roell Wilhelm, Lewalter Thorsten, Sasse Philipp, Tallini Yvonne N, Choi Bum-Rak, Breitbach Martin, Doran Robert, Becher Ulrich M, Hwang Seong-Min, Bostani Toktam, von Maltzahn Julia, Hofmann Andreas, Reining Shaun, Eiberger Britta, Gabris Bethann, Pfeifer Alexander, Welz Armin, Willecke Klaus, Salama Guy, Schrickel Jan W, Kotlikoff Michael I, Fleischmann Bernd K, ;2007;Nature;450;819-24; 18064002