MGI phenotypes (allele matching)
B6JIcoCrl.129P2-Rad52tm1Aps/Cnrm
| Status | Available to order |
| EMMA ID | EM:02592 |
| International strain name | B6JIcoCrl.129P2-Rad52tm1Aps/Cnrm |
| Alternative name | RAD52 mutant |
| Strain type | Targeted Mutant Strains : Knock-out |
| Allele/Transgene symbol | Rad52tm1Aps |
| Gene/Transgene symbol | Rad52 |
Information from provider
| Provider | Albert Pastink |
| Provider affiliation | IHB, LUMC |
| Genetic information | To inactivate the mouse Rad52 gene, a targeting construct was generated in which exon 3, that is located in the conserved part of the gene, was replaced by a neomycin resistance marker. |
| Phenotypic information | Homozygous Rad52 mutant animals do not show gross abnormalities or defects in fertility or in the immune system. At the cellular level, inactivation of both Rad52 alleles results in a reduced frequency of homologous recombination. Unlike yeast Rad52 mutant cells, ablation of Rad52 in mouse cells does not lead to an increased sensitivity to DNA damaging agents. |
| References |
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| Homozygous fertile | yes |
| Homozygous viable | yes |
| Homozygous matings required | no |
| Immunocompromised | no |
Information from EMMA
| Archiving centre | CNR, Consiglio Nazionale delle Ricerche, Monterotondo, Italy |
Disease and phenotype information
Literature references
- Targeted inactivation of mouse RAD52 reduces homologous recombination but not resistance to ionizing radiation.;Rijkers T, Van Den Ouweland J, Morolli B, Rolink A G, Baarends W M, Van Sloun P P, Lohman P H, Pastink A, ;1998;Molecular and cellular biology;18;6423-9; 9774658
- Inactivation of RAD52 aggravates RAD54 defects in mice but not in Schizosaccharomyces pombe.;de Vries Femke A T, Zonneveld José B M, van Duijn-Goedhart Annemarie, Roodbergen Marianne, Boei Jan, van Buul Paul P W, Essers Jeroen, van Steeg Harry, van Zeeland Albert A, van Benthem Jan, Pastink Albert, ;2005;DNA repair;4;1121-8; 16009599
- Suppression of retroviral infection by the RAD52 DNA repair protein.;Lau Alan, Kanaar Roland, Jackson Stephen P, O'Connor Mark J, ;2004;The EMBO journal;23;3421-9; 15297876