C3H101H x STOCK Foxp3sf/H

Status

Available to order

EMMA IDEM:02591
International strain nameC3H101H x STOCK Foxp3sf/H
Alternative nameFoxp3
Strain typeSpontaneous
Allele/Transgene symbolFoxp3sf
Gene/Transgene symbolFoxp3

Information from provider

ProviderLiane B. Russell
Provider affiliationMammalian Genetics Unit, MRC Harwell
Genetic informationInsertion of two adenosine residues into exon 8, resulting in a 2 bp shift in the reading frame. This allele is predicted to produce a truncated protein lacking the carboxy-terminal forkhead domain.
Phenotypic informationHeterozygous males can first be recognised at about 11 days of age by a reddening of the genital papilla. They develop scaliness first of the tail and later of other parts of the body. The skin appears tight and the eyelids open late. Scurfy males usually die before or shortly after weaning; survivors are small and sterile. Occasional scurfy females have proved to be X/O and resemble scurfy males. Heterozygous females are indistinguishable from homozygous wild-type females.
Breeding historyOutcrossed to C3H/HeH x 101/H
References
  • EXCEPTIONAL INHERITANCE OF A SEX-LINKED GENE IN THE MOUSE EXPLAINED ON THE BASIS THAT THE X/O SEX-CHROMOSOME CONSTITUTION IS FEMALE.;Russell W L, Russell L B, Gower J S, ;1959;Proceedings of the National Academy of Sciences of the United States of America;45;554-60; 16590412
Homozygous fertileno
Homozygous viableno
Homozygous matings requiredno
Immunocompromisednot known

Information from EMMA

Archiving centreMary Lyon Centre at MRC Harwell, Oxford, United Kingdom

Disease and phenotype information

MGI allele-associated human disease models

Orphanet associated rare diseases, based on orthologous gene matching

    • Immune dysregulation-polyendocrinopathy-enteropathy-X-linked syndrome / Orphanet_37042
MGI phenotypes (gene matching)
  • enlarged spleen / MGI
  • abnormal Peyer's patch morphology / MGI
  • decreased thymocyte number / MGI
  • scaly skin / MGI
  • dermatitis / MGI
  • weight loss / MGI
  • thymus hypoplasia / MGI
  • conjunctivitis / MGI
  • liver inflammation / MGI
  • lung inflammation / MGI
  • abnormal T cell differentiation / MGI
  • no abnormal phenotype detected / MGI
  • abnormal dendritic cell physiology / MGI
  • abnormal gut-associated lymphoid tissue morphology / MGI
  • no phenotypic analysis / MGI
  • lymph node inflammation / MGI
  • abnormal regulatory T cell morphology / MGI
  • increased regulatory T cell number / MGI
  • decreased regulatory T cell number / MGI
  • increased T cell number / MGI
  • decreased T cell number / MGI
  • decreased double-positive T cell number / MGI
  • cachexia / MGI
  • bradykinesia / MGI
  • abnormal mesenteric lymph node morphology / MGI
  • increased susceptibility to autoimmune disorder / MGI
  • immune system phenotype / MGI
  • abnormal CD4-positive, alpha-beta T cell physiology / MGI
  • increased susceptibility to type IV hypersensitivity reaction / MGI
  • increased T cell apoptosis / MGI
  • increased dendritic cell number / MGI
  • abnormal intraepithelial T cell morphology / MGI
  • increased sensitivity to induced morbidity/mortality / MGI
  • mortality/aging / MGI

Literature references

  • EXCEPTIONAL INHERITANCE OF A SEX-LINKED GENE IN THE MOUSE EXPLAINED ON THE BASIS THAT THE X/O SEX-CHROMOSOME CONSTITUTION IS FEMALE.;Russell W L, Russell L B, Gower J S, ;1959;Proceedings of the National Academy of Sciences of the United States of America;45;554-60; 16590412

Information on how we integrate external resources can be found here

Order

Availabilities

Requesting frozen sperm or embryos is generally advisable wherever possible, in order to minimise the shipment of live mice.

  • Frozen embryos. Delivered in 4 weeks (after paperwork in place). €1740*
  • Rederivation of mice from frozen stock, delivery time available upon request . €3880*
  • Tissue - Types of tissue, service fee and delivery time available upon request

Due to the dynamic nature of our processes strain availability may change at short notice. The local repository manager will advise you in these circumstances.

* In addition users have to cover all the shipping costs (including the cost for returning dry-shippers, where applicable).

More details on pricing and delivery times

Practical information

Example health report
(Current health report will be provided later)

Material Transfer Agreement (MTA)
MTA will be issued after an order has been submitted.

EMMA conditions
Legally binding conditions for the transfer

Other EMMA strains

Not found what you were looking for? Search here for other strains available from EMMA.


Search
INFRAFRONTIER® and European Mouse Mutant Archive - EMMA® are registered trademarks at the European Union Intellectual Property Office (EUIPO).