B6N.129-Artm1Verh/Cnrm

Status

Available to order

EMMA IDEM:02579
International strain nameB6N.129-Artm1Verh/Cnrm
Alternative nameARflox
Strain typeTargeted Mutant Strains : Conditional mutation
Allele/Transgene symbolArtm1Verh
Gene/Transgene symbolAr

Information from provider

ProviderGuido Verhoeven
Provider affiliationLEGENDO, Catholic University Leuven
Genetic informationMice carry an androgen receptor (Ar) gene on their X chromosome in which exon 2 is flanked by loxP-sites (floxed), allowing the generation of conditional (cell-specific) knockout of the Ar gene.
Phenotypic informationARflox mice do not exhibit any phenotype.
Breeding historyMice were backcrossed for over 12 generations with C57BL/6N mice.
References
  • A Sertoli cell-selective knockout of the androgen receptor causes spermatogenic arrest in meiosis.;De Gendt Karel, Swinnen Johannes V, Saunders Philippa T K, Schoonjans Luc, Dewerchin Mieke, Devos Ann, Tan Karen, Atanassova Nina, Claessens Frank, Lécureuil Charlotte, Heyns Walter, Carmeliet Peter, Guillou Florian, Sharpe Richard M, Verhoeven Guido, ;2004;Proceedings of the National Academy of Sciences of the United States of America;101;1327-32; 14745012
Homozygous fertileyes
Homozygous viableyes
Homozygous matings requiredno
Immunocompromisedno

Information from EMMA

Archiving centreCNR, Consiglio Nazionale delle Ricerche, Monterotondo, Italy

Disease and phenotype information

MGI phenotypes (gene matching)
  • muscle weakness / MGI
  • increased body weight / MGI
  • female infertility / MGI
  • preneoplasia / MGI
  • no abnormal phenotype detected / MGI
  • increased circulating testosterone level / MGI
  • decreased incidence of tumors by chemical induction / MGI
  • growth/size/body region phenotype / MGI
  • decreased grip strength / MGI
  • mortality/aging / MGI
  • increased urine major urinary protein level / MGI

Literature references

  • A Sertoli cell-selective knockout of the androgen receptor causes spermatogenic arrest in meiosis.;De Gendt Karel, Swinnen Johannes V, Saunders Philippa T K, Schoonjans Luc, Dewerchin Mieke, Devos Ann, Tan Karen, Atanassova Nina, Claessens Frank, Lécureuil Charlotte, Heyns Walter, Carmeliet Peter, Guillou Florian, Sharpe Richard M, Verhoeven Guido, ;2004;Proceedings of the National Academy of Sciences of the United States of America;101;1327-32; 14745012
  • Differential requirements of androgen receptor in luminal progenitors during prostate regeneration and tumor initiation.;Chua Chee Wai, Epsi Nusrat J, Leung Eva Y, Xuan Shouhong, Lei Ming, Li Bo I, Bergren Sarah K, Hibshoosh Hanina, Mitrofanova Antonina, Shen Michael M, ;2018;eLife;7;337; 29334357
  • Sex Hormones Regulate SHANK Expression.;Berkel Simone, Eltokhi Ahmed, Fröhlich Henning, Porras-Gonzalez Diana, Rafiullah Rafiullah, Sprengel Rolf, Rappold Gudrun A, ;2018;Frontiers in molecular neuroscience;11;; 30319350

Information on how we integrate external resources can be found here

Order

Availabilities

Requesting frozen sperm or embryos is generally advisable wherever possible, in order to minimise the shipment of live mice.

  • Frozen embryos. Delivered in 4 weeks (after paperwork in place). €1740*
  • Frozen sperm. Delivered in 4 weeks (after paperwork in place). €1740*
  • Rederivation of mice from frozen stock, delivery time available upon request . €3880*

Due to the dynamic nature of our processes strain availability may change at short notice. The local repository manager will advise you in these circumstances.

* In addition users have to cover all the shipping costs (including the cost for returning dry-shippers, where applicable).

More details on pricing and delivery times

Practical information

Example health report
(Current health report will be provided later)

Material Transfer Agreement (MTA)
For this strain no provider MTA is needed. Distribution is based on the EMMA conditions only.

EMMA conditions
Legally binding conditions for the transfer

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