- muscle weakness / MGI
- increased body weight / MGI
- female infertility / MGI
- preneoplasia / MGI
- no abnormal phenotype detected / MGI
- increased circulating testosterone level / MGI
- decreased incidence of tumors by chemical induction / MGI
- growth/size/body region phenotype / MGI
- decreased grip strength / MGI
- mortality/aging / MGI
- increased urine major urinary protein level / MGI
B6N.129-Artm1Verh/Cnrm
Status | Available to order |
EMMA ID | EM:02579 |
Citation information | RRID:IMSR_EM:02579 Research Resource Identifiers (RRID) are persistent unique ID numbers assigned to help researchers cite key resources (e.g. antibodies, model organisms and software projects) in the biomedical literature to improve transparency and reproducibility in research. See https://www.rrids.org/ for more information. |
International strain name | B6N.129-Artm1Verh/Cnrm |
Alternative name | ARflox |
Strain type | Targeted Mutant Strains : Conditional mutation |
Allele/Transgene symbol | Artm1Verh |
Gene/Transgene symbol | Ar |
Information from provider
Provider | Guido Verhoeven |
Provider affiliation | LEGENDO, Catholic University Leuven |
Genetic information | Mice carry an androgen receptor (Ar) gene on their X chromosome in which exon 2 is flanked by loxP-sites (floxed), allowing the generation of conditional (cell-specific) knockout of the Ar gene. |
Phenotypic information | ARflox mice do not exhibit any phenotype. |
Breeding history | Mice were backcrossed for over 12 generations with C57BL/6N mice. |
References |
|
Homozygous fertile | yes |
Homozygous viable | yes |
Homozygous matings required | no |
Immunocompromised | no |
Information from EMMA
Archiving centre | CNR, Consiglio Nazionale delle Ricerche, Monterotondo, Italy |
Disease and phenotype information
MGI phenotypes (gene matching)
Literature references
- A Sertoli cell-selective knockout of the androgen receptor causes spermatogenic arrest in meiosis.;De Gendt Karel, Swinnen Johannes V, Saunders Philippa T K, Schoonjans Luc, Dewerchin Mieke, Devos Ann, Tan Karen, Atanassova Nina, Claessens Frank, Lécureuil Charlotte, Heyns Walter, Carmeliet Peter, Guillou Florian, Sharpe Richard M, Verhoeven Guido, ;2004;Proceedings of the National Academy of Sciences of the United States of America;101;1327-32; 14745012
- Differential requirements of androgen receptor in luminal progenitors during prostate regeneration and tumor initiation.;Chua Chee Wai, Epsi Nusrat J, Leung Eva Y, Xuan Shouhong, Lei Ming, Li Bo I, Bergren Sarah K, Hibshoosh Hanina, Mitrofanova Antonina, Shen Michael M, ;2018;eLife;7;337; 29334357
- Sex Hormones Regulate SHANK Expression.;Berkel Simone, Eltokhi Ahmed, Fröhlich Henning, Porras-Gonzalez Diana, Rafiullah Rafiullah, Sprengel Rolf, Rappold Gudrun A, ;2018;Frontiers in molecular neuroscience;11;; 30319350
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