MGI phenotypes (allele matching)
B6;129P2-Prndtm1Aag/Cnrm
| Status | Available to order |
| EMMA ID | EM:02571 |
| Citation information | RRID:IMSR_EM:02571 Research Resource Identifiers (RRID) are persistent unique ID numbers assigned to help researchers cite key resources (e.g. antibodies, model organisms and software projects) in the biomedical literature to improve transparency and reproducibility in research. See https://www.rrids.org/ for more information. |
| International strain name | B6;129P2-Prndtm1Aag/Cnrm |
| Alternative name | B6,129-Prnd-/- |
| Strain type | Targeted Mutant Strains : Knock-out |
| Allele/Transgene symbol | Prndtm1Aag |
| Gene/Transgene symbol | Prnd |
Information from provider
| Provider | Adriano Aguzzi |
| Provider affiliation | Univ.Hosp.Zurich/Inst.Neuropathology |
| Additional owner | Dr. Andrew Steele, Whitehead Institute for Biomedical Research, Cambridge MA, USA |
| Genetic information | Knock-out of the Prnd gene, a double (German "doppel", Dpl) of the Prnp gene. The complete Prnd open reading frame is replaced with a neomycin resistance gene. |
| Phenotypic information | Homozygous males are infertile. Spermatids of Dpl mutants are reduced in numbers, immobile, malformed and unable to fertilize oocytes in vitro. |
| Breeding history | Prnd+/- males were backcrossed several times to C57BL/6 females. |
| References |
|
| Homozygous fertile | no |
| Homozygous viable | yes |
| Homozygous matings required | no |
| Immunocompromised | no |
Information from EMMA
| Archiving centre | CNR, Consiglio Nazionale delle Ricerche, Monterotondo, Italy |
Disease and phenotype information
MGI phenotypes (gene matching)
- impaired fertilization / MGI
- male infertility / MGI
- abnormal spermiogenesis / MGI
- asthenozoospermia / MGI
- oligozoospermia / MGI
- nervous system phenotype / MGI
- impaired acrosome reaction / MGI
- behavior/neurological phenotype / MGI
- immune system phenotype / MGI
- teratozoospermia / MGI
- abnormal acrosome morphology / MGI
- abnormal sperm head morphology / MGI
- hairpin sperm flagellum / MGI
Literature references
- Absence of the prion protein homologue Doppel causes male sterility.;Behrens Axel, Genoud Nicolas, Naumann Heike, Rülicke Thomas, Janett Fredi, Heppner Frank L, Ledermann Birgit, Aguzzi Adriano, ;2002;The EMBO journal;21;3652-8; 12110578
- Disruption of Doppel prevents neurodegeneration in mice with extensive Prnp deletions.;Genoud Nicolas, Behrens Axel, Miele Gino, Robay Dimitri, Heppner Frank L, Freigang Stefan, Aguzzi Adriano, ;2004;Proceedings of the National Academy of Sciences of the United States of America;101;4198-203; 15007175
- Prion proteins and infertility: insight from mouse models.;Genoud N, Behrens A, Arrighi I, Aguzzi A, ;2003;Cytogenetic and genome research;103;285-9; 15051949
- Normal neurogenesis and scrapie pathogenesis in neural grafts lacking the prion protein homologue Doppel.;Behrens A, Brandner S, Genoud N, Aguzzi A, ;2001;EMBO reports;2;347-52; 11306558