B6.129P2-Cited2tm1Bha/BhaH

Status

Available to order

EMMA IDEM:02569
International strain nameB6.129P2-Cited2tm1Bha/BhaH
Alternative nameCited2-tm1Bha
Strain typeTargeted Mutant Strains : Knock-out
Allele/Transgene symbolCited2tm1Bha,
Gene/Transgene symbolCited2

Information from provider

ProviderShoumo Bhattacharya
Provider affiliationDept of Cardiovascular Medicine, University of Oxford
Genetic informationTargeting construct is derived from 129 DNA. A neomycin-resistance gene cassette replaces all Cited2 exons.
Phenotypic informationCardiac malformations, adrenal agenesis, fusion of cranial ganglia, abnormal cardiac neural crest migration, exencephaly and left-right patterning defects.
Breeding historyThe line is maintained by backcrossing to C57BL/6J. It has been backcrossed 10+ generations.
References
  • Cardiac malformations, adrenal agenesis, neural crest defects and exencephaly in mice lacking Cited2, a new Tfap2 co-activator.;Bamforth S D, Bragança J, Eloranta J J, Murdoch J N, Marques F I, Kranc K R, Farza H, Henderson D J, Hurst H C, Bhattacharya S, ;2001;Nature genetics;29;469-74; 11694877
Homozygous fertileno
Homozygous viableno
Homozygous matings requiredno
Immunocompromisedno

Information from EMMA

Archiving centreMary Lyon Centre at MRC Harwell, Oxford, United Kingdom
Animals used for archivingheterozygous C57BL/6J
Breeding at archiving centreImported males were backcrossed to C57BL/6J before heterozygous sperm donors were archived.

Disease and phenotype information

Orphanet associated rare diseases, based on orthologous gene matching

MGI phenotypes (allele matching)
  • abnormal interventricular septum morphology / MGI
  • double outlet right ventricle / MGI
  • abnormal pulmonary trunk morphology / MGI
  • edema / MGI
  • postnatal lethality / MGI
  • right pulmonary isomerism / MGI
  • dextrocardia / MGI
  • mesocardia / MGI
  • small spleen / MGI
  • abnormal embryo turning / MGI
  • persistent truncus arteriosis / MGI
  • situs inversus / MGI
  • abnormal aortic arch morphology / MGI
  • interrupted aortic arch / MGI
  • right aortic arch / MGI
  • abnormal direction of heart looping / MGI
  • right atrial isomerism / MGI
  • abnormal inferior vena cava morphology / MGI
  • ventricular septal defect / MGI
  • common atrioventricular valve / MGI
  • abnormal tail position or orientation / MGI
  • abnormal heart ventricle morphology / MGI
  • absent adrenal gland / MGI
  • abnormal cardiac outflow tract development / MGI
  • ostium primum atrial septal defect / MGI
  • common atrium / MGI
  • vascular ring / MGI
  • abnormal heart development / MGI
  • overriding aortic valve / MGI
  • abnormal kidney development / MGI
  • exencephaly / MGI
  • fused dorsal root ganglion / MGI
  • small dorsal root ganglion / MGI
  • abnormal cranial ganglia morphology / MGI
  • abnormal heart atrium morphology / MGI
  • abnormal heart position or orientation / MGI
  • atrial septal defect / MGI
  • aberrant origin of the right subclavian artery / MGI
  • perinatal lethality, complete penetrance / MGI
  • embryonic lethality during organogenesis, incomplete penetrance / MGI
  • abnormal cardiac neural crest cell morphology / MGI
  • decreased cardiac neural crest cell number / MGI
  • absent cardiac neural crest cells / MGI

Literature references

  • Cardiac malformations, adrenal agenesis, neural crest defects and exencephaly in mice lacking Cited2, a new Tfap2 co-activator.;Bamforth S D, Bragança J, Eloranta J J, Murdoch J N, Marques F I, Kranc K R, Farza H, Henderson D J, Hurst H C, Bhattacharya S, ;2001;Nature genetics;29;469-74; 11694877

Information on how we integrate external resources can be found here

Order

Availabilities

Requesting frozen sperm or embryos is generally advisable wherever possible, in order to minimise the shipment of live mice.

  • Frozen sperm. Delivered in 4 weeks (after paperwork in place). €1740*
  • Rederivation of mice from frozen stock, delivery time available upon request . €3880*

Due to the dynamic nature of our processes strain availability may change at short notice. The local repository manager will advise you in these circumstances.

* In addition users have to cover all the shipping costs (including the cost for returning dry-shippers, where applicable).

More details on pricing and delivery times

Practical information

Example health report
(Current health report will be provided later)

Material Transfer Agreement (MTA)
MTA will be issued after an order has been submitted.

EMMA conditions
Legally binding conditions for the transfer

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