- abnormal interventricular septum morphology / MGI
- double outlet right ventricle / MGI
- abnormal pulmonary trunk morphology / MGI
- edema / MGI
- postnatal lethality / MGI
- right pulmonary isomerism / MGI
- dextrocardia / MGI
- mesocardia / MGI
- small spleen / MGI
- abnormal embryo turning / MGI
- persistent truncus arteriosis / MGI
- situs inversus / MGI
- abnormal aortic arch morphology / MGI
- interrupted aortic arch / MGI
- right aortic arch / MGI
- abnormal direction of heart looping / MGI
- right atrial isomerism / MGI
- abnormal inferior vena cava morphology / MGI
- ventricular septal defect / MGI
- common atrioventricular valve / MGI
- abnormal tail position or orientation / MGI
- abnormal heart ventricle morphology / MGI
- absent adrenal gland / MGI
- abnormal cardiac outflow tract development / MGI
- ostium primum atrial septal defect / MGI
- common atrium / MGI
- vascular ring / MGI
- abnormal heart development / MGI
- overriding aortic valve / MGI
- abnormal kidney development / MGI
- exencephaly / MGI
- fused dorsal root ganglion / MGI
- small dorsal root ganglion / MGI
- abnormal cranial ganglia morphology / MGI
- abnormal heart atrium morphology / MGI
- abnormal heart position or orientation / MGI
- atrial septal defect / MGI
- aberrant origin of the right subclavian artery / MGI
- perinatal lethality, complete penetrance / MGI
- embryonic lethality during organogenesis, incomplete penetrance / MGI
- abnormal cardiac neural crest cell morphology / MGI
- decreased cardiac neural crest cell number / MGI
- absent cardiac neural crest cells / MGI
B6.129P2-Cited2tm1Bha/BhaH
Status | Available to order |
EMMA ID | EM:02569 |
International strain name | B6.129P2-Cited2tm1Bha/BhaH |
Alternative name | Cited2-tm1Bha |
Strain type | Targeted Mutant Strains : Knock-out |
Allele/Transgene symbol | Cited2tm1Bha, |
Gene/Transgene symbol | Cited2 |
Information from provider
Provider | Shoumo Bhattacharya |
Provider affiliation | Dept of Cardiovascular Medicine, University of Oxford |
Genetic information | Targeting construct is derived from 129 DNA. A neomycin-resistance gene cassette replaces all Cited2 exons. |
Phenotypic information | Cardiac malformations, adrenal agenesis, fusion of cranial ganglia, abnormal cardiac neural crest migration, exencephaly and left-right patterning defects. |
Breeding history | The line is maintained by backcrossing to C57BL/6J. It has been backcrossed 10+ generations. |
References |
|
Homozygous fertile | no |
Homozygous viable | no |
Homozygous matings required | no |
Immunocompromised | no |
Information from EMMA
Archiving centre | Mary Lyon Centre at MRC Harwell, Oxford, United Kingdom |
Animals used for archiving | heterozygous C57BL/6J |
Breeding at archiving centre | Imported males were backcrossed to C57BL/6J before heterozygous sperm donors were archived. |
Disease and phenotype information
Orphanet associated rare diseases, based on orthologous gene matching
- Atrial septal defect, sinus venosus type / Orphanet_99105
- Atrial septal defect, ostium secundum type / Orphanet_99103
MGI phenotypes (allele matching)
Literature references
- Cardiac malformations, adrenal agenesis, neural crest defects and exencephaly in mice lacking Cited2, a new Tfap2 co-activator.;Bamforth S D, Bragança J, Eloranta J J, Murdoch J N, Marques F I, Kranc K R, Farza H, Henderson D J, Hurst H C, Bhattacharya S, ;2001;Nature genetics;29;469-74; 11694877
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