STOCK Fcgr1tm1Jsv/Cnrm

Status

Available to order

EMMA IDEM:02540
Citation informationRRID:IMSR_EM:02540 

Research Resource Identifiers (RRID) are persistent unique ID numbers assigned to help researchers cite key resources (e.g. antibodies, model organisms and software projects) in the biomedical literature to improve transparency and reproducibility in research. See https://www.rrids.org/ for more information.

 
International strain nameSTOCK Fcgr1tm1Jsv/Cnrm
Alternative nameCD64 KO on C57Bl6
Strain typeTargeted Mutant Strains : Knock-out
Allele/Transgene symbolFcgr1tm1Jsv
Gene/Transgene symbolFcgr1

Information from provider

ProviderJoseph Verbeek
Provider affiliationHuman Genetics, Leiden University Medical Center (LUMC)
Genetic informationDeletion of 3'-part of promoter, exon 1 (L1 domain), exon 2 (L2 domain) and 5'-part of exon 3 (ligand binding EC1 domain), replaced by PGK-hygromycin resistance cassette.
Phenotypic informationImpaired IgG2a antibody effector pathways.
Breeding historyGenerated with E14 129P2 ES cell line; F1-F2: C57BL/6 F3-F4 BALB/c F5-F12: C57BL/6
References
  • FcgammaRI (CD64) contributes substantially to severity of arthritis, hypersensitivity responses, and protection from bacterial infection.;Ioan-Facsinay A, de Kimpe S J, Hellwig S M M, van Lent P L, Hofhuis F M A, van Ojik H H, Sedlik C, da Silveira S A, Gerber J, de Jong Y F, Roozendaal R, Aarden L A, van den Berg W B, Saito T, Mosser D, Amigorena S, Izui S, van Ommen G J B, van Vugt M, van de Winkel J G J, Verbeek J S, ;2002;Immunity;16;391-402; 11911824
Homozygous fertileyes
Homozygous viableyes
Homozygous matings requiredno
Immunocompromisedyes

Information from EMMA

Archiving centreCNR, Consiglio Nazionale delle Ricerche, Monterotondo, Italy

Disease and phenotype information

MGI phenotypes (gene matching)
  • impaired macrophage phagocytosis / MGI
  • decreased inflammatory response / MGI
  • increased susceptibility to bacterial infection / MGI
  • abnormal cell-mediated immunity / MGI
  • abnormal macrophage physiology / MGI
  • abnormal macrophage antigen presentation / MGI
  • abnormal dendritic cell antigen presentation / MGI
  • increased IgG level / MGI
  • abnormal type I hypersensitivity reaction / MGI
  • decreased susceptibility to induced arthritis / MGI
  • decreased susceptibility to autoimmune hemolytic anemia / MGI
  • abnormal dendritic cell differentiation / MGI

Literature references

  • FcgammaRI (CD64) contributes substantially to severity of arthritis, hypersensitivity responses, and protection from bacterial infection.;Ioan-Facsinay A, de Kimpe S J, Hellwig S M M, van Lent P L, Hofhuis F M A, van Ojik H H, Sedlik C, da Silveira S A, Gerber J, de Jong Y F, Roozendaal R, Aarden L A, van den Berg W B, Saito T, Mosser D, Amigorena S, Izui S, van Ommen G J B, van Vugt M, van de Winkel J G J, Verbeek J S, ;2002;Immunity;16;391-402; 11911824

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Order

Availabilities

Requesting frozen sperm or embryos is generally advisable wherever possible, in order to minimise the shipment of live mice.

  • Frozen embryos. Delivered in 4 weeks (after paperwork in place). €1740*
  • Frozen sperm. Delivered in 4 weeks (after paperwork in place). €1740*
  • Rederivation of mice from frozen stock, delivery time available upon request . €3880*

Due to the dynamic nature of our processes strain availability may change at short notice. The local repository manager will advise you in these circumstances.

* In addition users have to cover all the shipping costs (including the cost for returning dry-shippers, where applicable).

More details on pricing and delivery times

Practical information

Example health report
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Material Transfer Agreement (MTA)
Distribution of this strain is subject to a provider MTA. Both signing of the MTA and submission of the online EMMA Mutant Request Form are required before material can be shipped.

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Legally binding conditions for the transfer

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