strain-details - INFRAFRONTIER

Information from provider

Status	Available to order
EMMA ID	EM:02531
International strain name	STOCK Dnah11^iv/H
Alternative name	iv
Strain type	Spontaneous
Allele/Transgene symbol	Dnah11^iv
Gene/Transgene symbol	Dnah11

Provider	Katharine Hummel
Provider affiliation	Medical Research Council
Additional owner	For further information contact Martin Fray, FESA Manager. m.fray@har.mrc.ac.uk
Genetic information	Homozygotes have randomised situs (sidedness).
Phenotypic information	50% of homozygotes have situs inversus totalis.
Breeding history	Complex mixed background; inbred over more than 20 generations.
References	Situs Viscerum Inversus;Hummel KP, Chapman D;1959;Mouse News Lett.;14;21; 9353118 Mutation of an axonemal dynein affects left-right asymmetry in inversus viscerum mice.;Supp D M, Witte D P, Potter S S, Brueckner M, ;1997;Nature;389;963-6;
Homozygous fertile	yes
Homozygous viable	yes
Homozygous matings required	no
Immunocompromised	not known

Disease and phenotype information

Archiving centre	Mary Lyon Centre at MRC Harwell, Oxford, United Kingdom

MGI allele-associated human disease models

primary ciliary dyskinesia 7 / DOID:0110605

Orphanet associated rare diseases, based on orthologous gene matching

Primary ciliary dyskinesia / Orphanet_244

MGI phenotypes (allele matching)

right pulmonary isomerism / MGI
abnormal autopod morphology / MGI
abnormal liver morphology / MGI
abnormal spleen morphology / MGI
abnormal embryo implantation / MGI
reduced fertility / MGI
abnormal cardiovascular system morphology / MGI
situs inversus / MGI
abnormal heart atrium morphology / MGI
left pulmonary isomerism / MGI
right atrial isomerism / MGI
abnormal inferior vena cava morphology / MGI
left atrial isomerism / MGI
increased physiological sensitivity to xenobiotic / MGI
abnormal heart atrium auricular region morphology / MGI
abnormal hepatic portal vein morphology / MGI
abnormal motile primary cilium morphology / MGI
heterotaxia / MGI
absent nodal flow / MGI

MGI phenotypes (gene matching)

abnormal heart morphology / MGI
heart right ventricle hypertrophy / MGI
double outlet right ventricle / MGI
abnormal mitral valve morphology / MGI
abnormal intestine morphology / MGI
hydronephrosis / MGI
right pulmonary isomerism / MGI
left-sided isomerism / MGI
abnormal autopod morphology / MGI
abnormal liver morphology / MGI
dextrocardia / MGI
mesocardia / MGI
abnormal spleen morphology / MGI
spleen hypoplasia / MGI
anophthalmia / MGI
microphthalmia / MGI
abnormal left-right axis patterning / MGI
abnormal embryo implantation / MGI
edema / MGI
reduced fertility / MGI
decreased litter size / MGI
abnormal respiration / MGI
perinatal lethality / MGI
abnormal cardiovascular system morphology / MGI
abnormal kidney morphology / MGI
no abnormal phenotype detected / MGI
abnormal myocardial trabeculae morphology / MGI
heart left ventricle hypertrophy / MGI
micrognathia / MGI
situs inversus / MGI
abnormal heart atrium morphology / MGI
left pulmonary isomerism / MGI
accessory spleen / MGI
decreased heart right ventricle size / MGI
kidney cysts / MGI
duplex kidney / MGI
abnormal primitive node morphology / MGI
abnormal motile primary cilium morphology / MGI
heterotaxia / MGI
interrupted aortic arch / MGI
right aortic arch / MGI
abnormal respiratory conducting tube morphology / MGI
abnormal vertebral column morphology / MGI
abnormal thoracic cavity morphology / MGI
abnormal biliary tract morphology / MGI
right atrial isomerism / MGI
abnormal inferior vena cava morphology / MGI
pulmonary valve stenosis / MGI
left atrial isomerism / MGI
polycystic kidney / MGI
increased physiological sensitivity to xenobiotic / MGI
abnormal motile primary cilium physiology / MGI
ventricular septal defect / MGI
ostium primum atrial septal defect / MGI
atrioventricular septal defect / MGI
complete atrioventricular septal defect / MGI
muscular ventricular septal defect / MGI
pulmonary artery hypoplasia / MGI
vascular ring / MGI
abnormal heart atrium auricular region morphology / MGI
common atrioventricular valve / MGI
abnormal hepatic portal vein morphology / MGI
abnormal stomach position or orientation / MGI
right-sided stomach / MGI
abnormal lung lobe morphology / MGI
abnormal respiratory motile cilium physiology / MGI
abdominal situs inversus / MGI
abdominal situs ambiguus / MGI
situs inversus totalis / MGI
situs inversus with levocardia / MGI
superior-inferior ventricles / MGI
biventricular, discordant atrioventricular connection / MGI
biventricular, ambiguous atrioventricular connection / MGI
immotile respiratory cilia / MGI
d-loop transposition of the great arteries / MGI
double outlet right ventricle, ventricular defect committed to aorta / MGI
dual inferior vena cava / MGI
isolation of the left subclavian artery / MGI
absent nodal flow / MGI

Literature references

Situs Viscerum Inversus;Hummel KP, Chapman D;1959;Mouse News Lett.;14;21; 9353118
Mutation of an axonemal dynein affects left-right asymmetry in inversus viscerum mice.;Supp D M, Witte D P, Potter S S, Brueckner M, ;1997;Nature;389;963-6;

Information on how we integrate external resources can be found here

Availabilities

Requesting frozen sperm or embryos is generally advisable wherever possible, in order to minimise the shipment of live mice.

Frozen embryos. Delivered in 4 weeks (after paperwork in place). €1740^*

Rederivation of mice from frozen stock, delivery time available upon request . €3880^*

Tissue - Types of tissue, service fee and delivery time available upon request

Due to the dynamic nature of our processes strain availability may change at short notice. The local repository manager will advise you in these circumstances.

^* In addition users have to cover all the shipping costs (including the cost for returning dry-shippers, where applicable).

STOCK Dnah11^iv/H

Information from provider

Information from EMMA

Disease and phenotype information

Literature references

Information on how we integrate external resources can be found here

Availabilities

Practical information

Other EMMA strains

STOCK Dnah11iv/H

Information from provider

Information from EMMA

Disease and phenotype information

Literature references

Information on how we integrate external resources can be found here

Availabilities

Practical information

Other EMMA strains

STOCK Dnah11^iv/H