STOCK Dnah11iv/H

Status

Available to order

EMMA IDEM:02531
Citation informationRRID:IMSR_EM:02531 

Research Resource Identifiers (RRID) are persistent unique ID numbers assigned to help researchers cite key resources (e.g. antibodies, model organisms and software projects) in the biomedical literature to improve transparency and reproducibility in research. See https://www.rrids.org/ for more information.

 
International strain nameSTOCK Dnah11iv/H
Alternative nameiv
Strain typeSpontaneous
Allele/Transgene symbolDnah11iv
Gene/Transgene symbolDnah11

Information from provider

ProviderKatharine Hummel
Provider affiliationMedical Research Council
Additional ownerFor further information contact Martin Fray, FESA Manager. m.fray@har.mrc.ac.uk
Genetic informationHomozygotes have randomised situs (sidedness).
Phenotypic information50% of homozygotes have situs inversus totalis.
Breeding historyComplex mixed background; inbred over more than 20 generations.
References
  • Situs Viscerum Inversus;Hummel KP, Chapman D;1959;Mouse News Lett.;14;21; 9353118
  • Mutation of an axonemal dynein affects left-right asymmetry in inversus viscerum mice.;Supp D M, Witte D P, Potter S S, Brueckner M, ;1997;Nature;389;963-6;
Homozygous fertileyes
Homozygous viableyes
Homozygous matings requiredno
Immunocompromisednot known

Information from EMMA

Archiving centreMary Lyon Centre at MRC Harwell, Oxford, United Kingdom

Disease and phenotype information

MGI allele-associated human disease models

Orphanet associated rare diseases, based on orthologous gene matching

MGI phenotypes (allele matching)
  • right pulmonary isomerism / MGI
  • abnormal autopod morphology / MGI
  • abnormal liver morphology / MGI
  • abnormal spleen morphology / MGI
  • abnormal embryo implantation / MGI
  • reduced fertility / MGI
  • abnormal cardiovascular system morphology / MGI
  • situs inversus / MGI
  • abnormal heart atrium morphology / MGI
  • left pulmonary isomerism / MGI
  • right atrial isomerism / MGI
  • abnormal inferior vena cava morphology / MGI
  • left atrial isomerism / MGI
  • increased physiological sensitivity to xenobiotic / MGI
  • abnormal heart atrium auricular region morphology / MGI
  • abnormal hepatic portal vein morphology / MGI
  • abnormal motile primary cilium morphology / MGI
  • heterotaxia / MGI
  • absent nodal flow / MGI
MGI phenotypes (gene matching)
  • abnormal heart morphology / MGI
  • heart right ventricle hypertrophy / MGI
  • double outlet right ventricle / MGI
  • abnormal mitral valve morphology / MGI
  • abnormal intestine morphology / MGI
  • hydronephrosis / MGI
  • right pulmonary isomerism / MGI
  • left-sided isomerism / MGI
  • abnormal autopod morphology / MGI
  • abnormal liver morphology / MGI
  • dextrocardia / MGI
  • mesocardia / MGI
  • abnormal spleen morphology / MGI
  • spleen hypoplasia / MGI
  • anophthalmia / MGI
  • microphthalmia / MGI
  • abnormal left-right axis patterning / MGI
  • abnormal embryo implantation / MGI
  • edema / MGI
  • reduced fertility / MGI
  • decreased litter size / MGI
  • abnormal respiration / MGI
  • perinatal lethality / MGI
  • abnormal cardiovascular system morphology / MGI
  • abnormal kidney morphology / MGI
  • no abnormal phenotype detected / MGI
  • abnormal myocardial trabeculae morphology / MGI
  • heart left ventricle hypertrophy / MGI
  • micrognathia / MGI
  • situs inversus / MGI
  • abnormal heart atrium morphology / MGI
  • left pulmonary isomerism / MGI
  • accessory spleen / MGI
  • decreased heart right ventricle size / MGI
  • kidney cysts / MGI
  • duplex kidney / MGI
  • abnormal primitive node morphology / MGI
  • abnormal motile primary cilium morphology / MGI
  • heterotaxia / MGI
  • interrupted aortic arch / MGI
  • right aortic arch / MGI
  • abnormal respiratory conducting tube morphology / MGI
  • abnormal vertebral column morphology / MGI
  • abnormal thoracic cavity morphology / MGI
  • abnormal biliary tract morphology / MGI
  • right atrial isomerism / MGI
  • abnormal inferior vena cava morphology / MGI
  • pulmonary valve stenosis / MGI
  • left atrial isomerism / MGI
  • polycystic kidney / MGI
  • increased physiological sensitivity to xenobiotic / MGI
  • abnormal motile primary cilium physiology / MGI
  • ventricular septal defect / MGI
  • ostium primum atrial septal defect / MGI
  • atrioventricular septal defect / MGI
  • complete atrioventricular septal defect / MGI
  • muscular ventricular septal defect / MGI
  • pulmonary artery hypoplasia / MGI
  • vascular ring / MGI
  • abnormal heart atrium auricular region morphology / MGI
  • common atrioventricular valve / MGI
  • abnormal hepatic portal vein morphology / MGI
  • abnormal stomach position or orientation / MGI
  • right-sided stomach / MGI
  • abnormal lung lobe morphology / MGI
  • abnormal respiratory motile cilium physiology / MGI
  • abdominal situs inversus / MGI
  • abdominal situs ambiguus / MGI
  • situs inversus totalis / MGI
  • situs inversus with levocardia / MGI
  • superior-inferior ventricles / MGI
  • biventricular, discordant atrioventricular connection / MGI
  • biventricular, ambiguous atrioventricular connection / MGI
  • immotile respiratory cilia / MGI
  • d-loop transposition of the great arteries / MGI
  • double outlet right ventricle, ventricular defect committed to aorta / MGI
  • dual inferior vena cava / MGI
  • isolation of the left subclavian artery / MGI
  • absent nodal flow / MGI

Literature references

  • Situs Viscerum Inversus;Hummel KP, Chapman D;1959;Mouse News Lett.;14;21; 9353118
  • Mutation of an axonemal dynein affects left-right asymmetry in inversus viscerum mice.;Supp D M, Witte D P, Potter S S, Brueckner M, ;1997;Nature;389;963-6;

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Availabilities

Requesting frozen sperm or embryos is generally advisable wherever possible, in order to minimise the shipment of live mice.

  • Frozen embryos. Delivered in 4 weeks (after paperwork in place). €1740*
  • Rederivation of mice from frozen stock, delivery time available upon request . €3880*
  • Tissue - Types of tissue, service fee and delivery time available upon request

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