STOCK Hnf4atm1(cre)Sdv/H

Status

Available to order

EMMA IDEM:02506
Citation informationRRID:IMSR_EM:02506 

Research Resource Identifiers (RRID) are persistent unique ID numbers assigned to help researchers cite key resources (e.g. antibodies, model organisms and software projects) in the biomedical literature to improve transparency and reproducibility in research. See https://www.rrids.org/ for more information.

 
International strain nameSTOCK Hnf4atm1(cre)Sdv/H
Alternative nameHnf4 cre
Strain typeTargeted Mutant Strains : Knock-in
Allele/Transgene symbolHnf4atm1(cre)Sdv
Gene/Transgene symbolHnf4a

Information from provider

ProviderElizabeth Robertson
Provider affiliationSir William Dunn School of Pathology, University of Oxford
Genetic informationStrain carries a knock-in of cre recombinase into the Hnf4a locus. Strain expresses Cre efficiently in the hepatocytes of the developing liver to allow conditional gene deletion or activation in this lineage.
Phenotypic informationHomozygous lethal at mid gestation due to defects in liver formation.
Breeding historyBackcrossed on a 129S/SvEv background.
ReferencesNone available
Homozygous fertileno
Homozygous viableno
Homozygous matings requiredno
Immunocompromisednot known

Information from EMMA

Archiving centreMary Lyon Centre at MRC Harwell, Oxford, United Kingdom

Disease and phenotype information

Orphanet associated rare diseases, based on orthologous gene matching

IMPC phenotypes (gene matching)
  • increased circulating HDL cholesterol level / IMPC
  • increased total retina thickness / IMPC
  • persistence of hyaloid vascular system / IMPC
  • enlarged thyroid gland / IMPC
  • abnormal retina blood vessel morphology / IMPC
  • increased circulating bilirubin level / IMPC
  • increased circulating calcium level / IMPC
  • abnormal lens morphology / IMPC
  • abnormal retina morphology / IMPC
  • cataract / IMPC
  • improved glucose tolerance / IMPC
  • abnormal retina vasculature morphology / IMPC
  • decreased body weight / IMPC
  • increased circulating cholesterol level / IMPC
MGI phenotypes (gene matching)
  • abnormal embryo development / MGI
  • abnormal ectoderm development / MGI
  • absent mesoderm / MGI
  • abnormal gastrulation / MGI
  • decreased embryo size / MGI
  • abnormal embryonic tissue morphology / MGI
  • abnormal extraembryonic tissue morphology / MGI
  • abnormal lipid homeostasis / MGI
  • no abnormal phenotype detected / MGI
  • abnormal primitive streak formation / MGI
  • increased circulating ketone body level / MGI
  • hepatic steatosis / MGI
  • decreased circulating triglyceride level / MGI
  • decreased circulating free fatty acid level / MGI
  • absent allantois / MGI
  • increased ectoderm apoptosis / MGI
  • embryonic growth retardation / MGI
  • hypokalemia / MGI
  • decreased circulating iron level / MGI
  • absent amnion / MGI
  • decreased circulating cholesterol level / MGI
  • impaired glucose tolerance / MGI
  • increased circulating bilirubin level / MGI
  • absent chorion / MGI
  • embryonic lethality, complete penetrance / MGI
  • preweaning lethality, complete penetrance / MGI
  • delayed gastrulation / MGI
  • small visceral yolk sac / MGI
  • increased embryonic tissue cell apoptosis / MGI

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Order

Availabilities

Requesting frozen sperm or embryos is generally advisable wherever possible, in order to minimise the shipment of live mice.

  • Frozen embryos. Delivered in 4 weeks (after paperwork in place). €1740*
  • Rederivation of mice from frozen stock, delivery time available upon request . €3880*
  • Tissue - Types of tissue, service fee and delivery time available upon request

Due to the dynamic nature of our processes strain availability may change at short notice. The local repository manager will advise you in these circumstances.

* In addition users have to cover all the shipping costs (including the cost for returning dry-shippers, where applicable).

More details on pricing and delivery times

Practical information

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