B6.129P2(Cg)-Il1rntm1Nick/NickH

Status

Available to order

EMMA IDEM:02498
International strain nameB6.129P2(Cg)-Il1rntm1Nick/NickH
Alternative nameC57BL/6 Il1rn
Strain typeTargeted Mutant Strains : Knock-out
Allele/Transgene symbolIl1rntm1Nick
Gene/Transgene symbolIl1rn

Information from provider

ProviderMartin Nicklin
Provider affiliationSchool of Medicine, University of Sheffield
Genetic informationInactivation of all isoforms of Il1rn by targeted replacement. Mutant locus contains plasmid and Neo marker. Strain lacks interleukin-1 receptor antagonist.
Phenotypic informationStrain resistant to arthritis, arteritis and psoriasis (seen in BALB/c background) but highly susceptible to undefined "malaise" under conventional conditions.
Breeding history129P2 chim. outbr. to MF1, inbred 4 gen., barrier rederived, backcrossed 4 gen. to BALB/cAnN then backcrossed to B6.
References
  • Elastic-vessel arteritis in interleukin-1 receptor antagonist-deficient mice involves effector Th1 cells and requires interleukin-1 receptor.;Shepherd Joanna, Nicklin Martin J H, ;2005;Circulation;111;3135-40; 15939811
  • Stimulation of TLR2 and TLR4 differentially skews the balance of T cells in a mouse model of arthritis.;Abdollahi-Roodsaz Shahla, Joosten Leo A B, Koenders Marije I, Devesa Isabel, Roelofs Mieke F, Radstake Timothy R D J, Heuvelmans-Jacobs Marleen, Akira Shizuo, Nicklin Martin J H, Ribeiro-Dias Fátima, van den Berg Wim B, ;2008;The Journal of clinical investigation;118;205-16; 18060042
Homozygous fertileyes
Homozygous viableyes
Homozygous matings requiredno
Immunocompromisedno

Information from EMMA

Archiving centreMary Lyon Centre at MRC Harwell, Oxford, United Kingdom
Animals used for archivinghomozygous C57BL/6
Breeding at archiving centreMales were archived by sperm freezing on arrival. No breeding was performed at the archiving centre.

Disease and phenotype information

Orphanet associated rare diseases, based on orthologous gene matching

    • Sterile multifocal osteomyelitis with periostitis and pustulosis / Orphanet_210115
MGI phenotypes (allele matching)
  • aortitis / MGI
  • immune system phenotype / MGI
  • hemorrhage / MGI
  • premature death / MGI
  • chronic inflammation / MGI
  • artery stenosis / MGI
  • skin inflammation / MGI
  • psoriasis / MGI
  • skin lesions / MGI
  • abnormal epidermal layer morphology / MGI
  • thick epidermis / MGI
  • epidermal desquamation / MGI
  • abnormal dermal layer morphology / MGI
  • thick dermal layer / MGI
  • parakeratosis / MGI
  • abnormal keratinocyte physiology / MGI
  • rheumatoid arthritis / MGI
  • pathological neovascularization / MGI
MGI phenotypes (gene matching)
  • psoriasis / MGI
  • skin lesions / MGI
  • abnormal epidermal layer morphology / MGI
  • thick epidermis / MGI
  • epidermal desquamation / MGI
  • abnormal dermal layer morphology / MGI
  • thick dermal layer / MGI
  • decreased body weight / MGI
  • postnatal growth retardation / MGI
  • abnormal body temperature homeostasis / MGI
  • hemorrhage / MGI
  • reduced fertility / MGI
  • premature death / MGI
  • decreased susceptibility to bacterial infection / MGI
  • abnormal CD4-positive, alpha beta T cell morphology / MGI
  • abnormal T-helper 1 cell morphology / MGI
  • abnormal T-helper 2 cell morphology / MGI
  • chronic inflammation / MGI
  • granulomatous inflammation / MGI
  • abnormal immune system organ morphology / MGI
  • parakeratosis / MGI
  • abnormal keratinocyte physiology / MGI
  • rheumatoid arthritis / MGI
  • pathological neovascularization / MGI
  • abnormal vascular wound healing / MGI
  • skin inflammation / MGI
  • increased acute inflammation / MGI
  • decreased circulating cholesterol level / MGI
  • immune system phenotype / MGI
  • artery stenosis / MGI
  • abnormal dendritic cell differentiation / MGI
  • abnormal dendritic cell number / MGI
  • decreased circulating interleukin-1 level / MGI
  • increased circulating interleukin-6 level / MGI
  • increased interleukin-17 secretion / MGI
  • increased susceptibility to endotoxin shock / MGI
  • aortitis / MGI
  • abnormal circulating serum amyloid protein level / MGI

Literature references

  • Elastic-vessel arteritis in interleukin-1 receptor antagonist-deficient mice involves effector Th1 cells and requires interleukin-1 receptor.;Shepherd Joanna, Nicklin Martin J H, ;2005;Circulation;111;3135-40; 15939811
  • Stimulation of TLR2 and TLR4 differentially skews the balance of T cells in a mouse model of arthritis.;Abdollahi-Roodsaz Shahla, Joosten Leo A B, Koenders Marije I, Devesa Isabel, Roelofs Mieke F, Radstake Timothy R D J, Heuvelmans-Jacobs Marleen, Akira Shizuo, Nicklin Martin J H, Ribeiro-Dias Fátima, van den Berg Wim B, ;2008;The Journal of clinical investigation;118;205-16; 18060042

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Order

Availabilities

Requesting frozen sperm or embryos is generally advisable wherever possible, in order to minimise the shipment of live mice.

  • Frozen sperm. Delivered in 4 weeks (after paperwork in place). €1740*
  • Rederivation of mice from frozen stock, delivery time available upon request . €3880*
  • Tissue - Types of tissue, service fee and delivery time available upon request

Due to the dynamic nature of our processes strain availability may change at short notice. The local repository manager will advise you in these circumstances.

* In addition users have to cover all the shipping costs (including the cost for returning dry-shippers, where applicable).

More details on pricing and delivery times

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