CAnN.129P2(MF1)-Il1rntm1Nick/NickH

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EMMA IDEM:02497
Citation informationRRID:IMSR_EM:02497 

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International strain nameCAnN.129P2(MF1)-Il1rntm1Nick/NickH
Alternative nameBALB/cAnNHsd Il1rn
Strain typeTargeted Mutant Strains : Knock-out
Allele/Transgene symbolIl1rntm1Nick
Gene/Transgene symbolIl1rn

Information from provider

ProviderMartin Nicklin
Provider affiliationSchool of Medicine, University of Sheffield
Genetic informationInactivation of all isoforms of Il1rn by targeted replacement. Mutant locus contains plasmid and Neo marker. Strain lacks interleukin-1 receptor antagonist.
Phenotypic informationStrain sporadically and independently develops rheumatoid-like arthritis, localised psoriasis-like lesions and patchy transmural destructive arteritis of the elastic vessels. Hygiene dependent (negative correlation). Different strain dependence of each disease. This strain, in our SPF lab: 80% affected (each disease independently) at 200 days.
Breeding history129P2/OlaHsd chim. outbred to MF1, inbred 4 gen., barrier rederived, backcrossed to BALB/cAnN.
References
  • Arterial inflammation in mice lacking the interleukin 1 receptor antagonist gene.;Nicklin M J, Hughes D E, Barton J L, Ure J M, Duff G W, ;2000;The Journal of experimental medicine;191;303-12; 10637274
  • Psoriasis-like cutaneous inflammation in mice lacking interleukin-1 receptor antagonist.;Shepherd Joanna, Little Matthew C, Nicklin Martin J H, ;2004;The Journal of investigative dermatology;122;665-9; 15086551
  • Elastic-vessel arteritis in interleukin-1 receptor antagonist-deficient mice involves effector Th1 cells and requires interleukin-1 receptor.;Shepherd Joanna, Nicklin Martin J H, ;2005;Circulation;111;3135-40; 15939811
  • Stimulation of TLR2 and TLR4 differentially skews the balance of T cells in a mouse model of arthritis.;Abdollahi-Roodsaz Shahla, Joosten Leo A B, Koenders Marije I, Devesa Isabel, Roelofs Mieke F, Radstake Timothy R D J, Heuvelmans-Jacobs Marleen, Akira Shizuo, Nicklin Martin J H, Ribeiro-Dias Fátima, van den Berg Wim B, ;2008;The Journal of clinical investigation;118;205-16; 18060042
Homozygous fertileyes
Homozygous viableyes
Homozygous matings requiredno
Immunocompromisedno

Information from EMMA

Archiving centreMary Lyon Centre at MRC Harwell, Oxford, United Kingdom
Animals used for archivinghomozygous BALB/cAnN males
Breeding at archiving centreMales were archived by sperm freezing on arrival. No breeding was performed at the archiving centre.

Disease and phenotype information

Orphanet associated rare diseases, based on orthologous gene matching

    • Sterile multifocal osteomyelitis with periostitis and pustulosis / Orphanet_210115
MGI phenotypes (allele matching)
  • aortitis / MGI
  • immune system phenotype / MGI
  • hemorrhage / MGI
  • premature death / MGI
  • chronic inflammation / MGI
  • artery stenosis / MGI
  • skin inflammation / MGI
  • psoriasis / MGI
  • skin lesions / MGI
  • abnormal epidermal layer morphology / MGI
  • thick epidermis / MGI
  • epidermal desquamation / MGI
  • abnormal dermal layer morphology / MGI
  • thick dermal layer / MGI
  • parakeratosis / MGI
  • abnormal keratinocyte physiology / MGI
  • rheumatoid arthritis / MGI
  • pathological neovascularization / MGI
MGI phenotypes (gene matching)
  • psoriasis / MGI
  • skin lesions / MGI
  • abnormal epidermal layer morphology / MGI
  • thick epidermis / MGI
  • epidermal desquamation / MGI
  • abnormal dermal layer morphology / MGI
  • thick dermal layer / MGI
  • decreased body weight / MGI
  • postnatal growth retardation / MGI
  • abnormal body temperature homeostasis / MGI
  • hemorrhage / MGI
  • reduced fertility / MGI
  • premature death / MGI
  • decreased susceptibility to bacterial infection / MGI
  • abnormal CD4-positive, alpha beta T cell morphology / MGI
  • abnormal T-helper 1 cell morphology / MGI
  • abnormal T-helper 2 cell morphology / MGI
  • chronic inflammation / MGI
  • granulomatous inflammation / MGI
  • abnormal immune system organ morphology / MGI
  • parakeratosis / MGI
  • abnormal keratinocyte physiology / MGI
  • rheumatoid arthritis / MGI
  • pathological neovascularization / MGI
  • abnormal vascular wound healing / MGI
  • skin inflammation / MGI
  • increased acute inflammation / MGI
  • decreased circulating cholesterol level / MGI
  • immune system phenotype / MGI
  • artery stenosis / MGI
  • abnormal dendritic cell differentiation / MGI
  • abnormal dendritic cell number / MGI
  • decreased circulating interleukin-1 level / MGI
  • increased circulating interleukin-6 level / MGI
  • increased interleukin-17 secretion / MGI
  • increased susceptibility to endotoxin shock / MGI
  • aortitis / MGI
  • abnormal circulating serum amyloid protein level / MGI

Literature references

  • Arterial inflammation in mice lacking the interleukin 1 receptor antagonist gene.;Nicklin M J, Hughes D E, Barton J L, Ure J M, Duff G W, ;2000;The Journal of experimental medicine;191;303-12; 10637274
  • Psoriasis-like cutaneous inflammation in mice lacking interleukin-1 receptor antagonist.;Shepherd Joanna, Little Matthew C, Nicklin Martin J H, ;2004;The Journal of investigative dermatology;122;665-9; 15086551
  • Elastic-vessel arteritis in interleukin-1 receptor antagonist-deficient mice involves effector Th1 cells and requires interleukin-1 receptor.;Shepherd Joanna, Nicklin Martin J H, ;2005;Circulation;111;3135-40; 15939811
  • Stimulation of TLR2 and TLR4 differentially skews the balance of T cells in a mouse model of arthritis.;Abdollahi-Roodsaz Shahla, Joosten Leo A B, Koenders Marije I, Devesa Isabel, Roelofs Mieke F, Radstake Timothy R D J, Heuvelmans-Jacobs Marleen, Akira Shizuo, Nicklin Martin J H, Ribeiro-Dias Fátima, van den Berg Wim B, ;2008;The Journal of clinical investigation;118;205-16; 18060042
  • [18F]FDG PET-MR characterization of aortitis in the IL1rn-/- mouse model of giant-cell arteritis.;Deshayes Samuel, Baugé Caroline, Dupont Pierre-Antoine, Simard Christophe, Rida Hanan, de Boysson Hubert, Manrique Alain, Aouba Achille, ;2023;EJNMMI research;13;103; 38019303

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