IMPC phenotypes (gene matching)
CAnN.129S7(B6)-Il1r1tm1Imx/NickH
| Status | Available to order |
| EMMA ID | EM:02496 |
| Citation information | RRID:IMSR_EM:02496 Research Resource Identifiers (RRID) are persistent unique ID numbers assigned to help researchers cite key resources (e.g. antibodies, model organisms and software projects) in the biomedical literature to improve transparency and reproducibility in research. See https://www.rrids.org/ for more information. |
| International strain name | CAnN.129S7(B6)-Il1r1tm1Imx/NickH |
| Alternative name | BALB/cAnNHsd Il1r1 |
| Strain type | Targeted Mutant Strains : Knock-out |
| Allele/Transgene symbol | Il1r1tm1Imx |
| Gene/Transgene symbol | Il1r1 |
Information from provider
| Provider | Martin Nicklin |
| Provider affiliation | School of Medicine, University of Sheffield |
| Additional owner | Dr. Jacques Peschon, Institute of Systems Biology, Seattle WA, USA |
| Genetic information | N10 introgression of Il1r1tm1Imx into BALB/cAnNHsd. |
| Phenotypic information | The mice are deficient in the only functional receptor for interleukin-1. |
| Breeding history | Received B6-Il1r1tm1Imx from Immunex. Rederived to barrier and backcrossed 11 gen. to BALB/cAnN. |
| References |
|
| Homozygous fertile | yes |
| Homozygous viable | yes |
| Homozygous matings required | no |
| Immunocompromised | not known |
Information from EMMA
| Archiving centre | Mary Lyon Centre at MRC Harwell, Oxford, United Kingdom |
| Animals used for archiving | homozygous BALB/cAnN males |
| Breeding at archiving centre | Males were archived by sperm freezing on arrival. No breeding was performed at the archiving centre. |
Disease and phenotype information
MGI phenotypes (allele matching)
- increased body length / MGI
- increased body weight / MGI
- weight loss / MGI
- decreased anxiety-related response / MGI
- hypoactivity / MGI
- increased circulating insulin level / MGI
- abnormal nervous system electrophysiology / MGI
- increased susceptibility to bacterial infection / MGI
- enhanced wound healing / MGI
- increased growth rate / MGI
- increased liver weight / MGI
- increased susceptibility to age related obesity / MGI
- increased susceptibility to induced arthritis / MGI
- abnormal lean body mass / MGI
- increased circulating insulin-like growth factor I level / MGI
- abnormal vascular wound healing / MGI
- sepsis / MGI
- impaired glucose tolerance / MGI
- insulin resistance / MGI
- abnormal food intake / MGI
- increased percent body fat/body weight / MGI
- increased circulating leptin level / MGI
- increased body mass index / MGI
- decreased tumor necrosis factor secretion / MGI
- decreased circulating interleukin-6 level / MGI
- increased circulating interleukin-18 level / MGI
- decreased circulating interleukin-18 level / MGI
- increased circulating interleukin-1 beta level / MGI
- decreased interleukin-6 secretion / MGI
- decreased transforming growth factor level / MGI
- increased gonadal fat pad weight / MGI
- increased abdominal fat pad weight / MGI
- increased inguinal fat pad weight / MGI
- increased mesenteric fat pad weight / MGI
- increased retroperitoneal fat pad weight / MGI
- enhanced contextual conditioning behavior / MGI
- increased susceptibility to bacterial infection induced morbidity/mortality / MGI
- increased total body fat amount / MGI
- increased respiratory quotient / MGI
- immune system phenotype / MGI
- increased bone resorption / MGI
- osteomyelitis / MGI
- dental pulp necrosis / MGI
- abnormal neutrophil physiology / MGI
- abnormal response/metabolism to endogenous compounds / MGI
- decreased susceptibility to kidney reperfusion injury / MGI
- decreased susceptibility to experimental autoimmune uveoretinitis / MGI
- decreased circulating creatinine level / MGI
- decreased blood urea nitrogen level / MGI
- delayed tooth eruption / MGI
MGI phenotypes (gene matching)
- decreased neutrophil cell number / MGI
- abnormal cell death / MGI
- increased body length / MGI
- increased body weight / MGI
- weight loss / MGI
- decreased anxiety-related response / MGI
- hypoactivity / MGI
- abnormal inflammatory response / MGI
- increased circulating insulin level / MGI
- no abnormal phenotype detected / MGI
- abnormal nervous system electrophysiology / MGI
- increased susceptibility to bacterial infection / MGI
- decreased immunoglobulin level / MGI
- abnormal neutrophil physiology / MGI
- enhanced wound healing / MGI
- increased growth rate / MGI
- increased liver weight / MGI
- delayed tooth eruption / MGI
- increased susceptibility to age related obesity / MGI
- decreased susceptibility to induced arthritis / MGI
- abnormal response/metabolism to endogenous compounds / MGI
- increased susceptibility to induced arthritis / MGI
- impaired febrile response / MGI
- abnormal lean body mass / MGI
- decreased susceptibility to kidney reperfusion injury / MGI
- decreased incidence of tumors by chemical induction / MGI
- increased circulating insulin-like growth factor I level / MGI
- decreased susceptibility to autoimmune diabetes / MGI
- decreased susceptibility to experimental autoimmune uveoretinitis / MGI
- abnormal vascular wound healing / MGI
- increased bone resorption / MGI
- decreased eosinophil cell number / MGI
- decreased T cell number / MGI
- sepsis / MGI
- decreased T cell proliferation / MGI
- osteomyelitis / MGI
- impaired glucose tolerance / MGI
- insulin resistance / MGI
- homeostasis/metabolism phenotype / MGI
- immune system phenotype / MGI
- abnormal food intake / MGI
- increased percent body fat/body weight / MGI
- decreased circulating creatinine level / MGI
- decreased blood urea nitrogen level / MGI
- decreased susceptibility to type IV hypersensitivity reaction / MGI
- increased circulating leptin level / MGI
- increased body mass index / MGI
- decreased tumor necrosis factor secretion / MGI
- decreased circulating interleukin-6 level / MGI
- increased circulating interleukin-18 level / MGI
- decreased circulating interleukin-18 level / MGI
- increased circulating interleukin-1 beta level / MGI
- decreased interleukin-6 secretion / MGI
- impaired neutrophil chemotaxis / MGI
- decreased transforming growth factor level / MGI
- increased gonadal fat pad weight / MGI
- increased abdominal fat pad weight / MGI
- increased inguinal fat pad weight / MGI
- increased mesenteric fat pad weight / MGI
- increased retroperitoneal fat pad weight / MGI
- enhanced contextual conditioning behavior / MGI
- increased susceptibility to bacterial infection induced morbidity/mortality / MGI
- increased total body fat amount / MGI
- abnormal circulating serum amyloid protein level / MGI
- increased respiratory quotient / MGI
- abnormal microglial cell activation / MGI
- integument phenotype / MGI
- dental pulp necrosis / MGI
Literature references
- Phenotypic and functional characterization of mice that lack the type I receptor for IL-1.;Glaccum M B, Stocking K L, Charrier K, Smith J L, Willis C R, Maliszewski C, Livingston D J, Peschon J J, Morrissey P J, ;1997;Journal of immunology (Baltimore, Md. : 1950);159;3364-71; 9317135