- abnormal retina inner nuclear layer morphology / IMPC
- dysplasia / IMPC
- enlarged heart / IMPC
- decreased NK cell number / IMPC
- increased mean corpuscular volume / IMPC
- decreased total retina thickness / IMPC
- unresponsive to tactile stimuli / IMPC
- decreased total body fat amount / IMPC
- preweaning lethality, incomplete penetrance / IMPC
- abnormal eye posterior chamber depth / IMPC
- increased bone mineral content / IMPC
- decreased circulating alkaline phosphatase level / IMPC
- increased circulating iron level / IMPC
- decreased hemoglobin content / IMPC
- abnormal eye anterior chamber depth / IMPC
- abnormal eye morphology / IMPC
- decreased cardiac output / IMPC
- metaplasia / IMPC
- decreased thigmotaxis / IMPC
- hyperactivity / IMPC
B6.129S2-Nr1d1tm1Schb/Cnrm
Status | Available to order |
EMMA ID | EM:02487 |
International strain name | B6.129S2-Nr1d1tm1Schb/Cnrm |
Alternative name | REV-ERBalpha-KO |
Strain type | Targeted Mutant Strains : Knock-out |
Allele/Transgene symbol | Nr1d1tm1Schb |
Gene/Transgene symbol | Nr1d1 |
Information from provider
Provider | Ueli Schibler |
Provider affiliation | University of Geneva |
Genetic information | A genomic fragment containing part of exon 2, exons 3 and 4 and part of exon 5 was replaced with an in-frame lacZ gene and a neomycin selection cassette. Northern blot analysis demonstrated that no detectable transcript is expressed from this allele, and Western blot analysis confirmed that no detectable protein is made from this allele. |
Phenotypic information | Homozygotes for targeted null mutations exhibit altered circadian behavior and mild alterations in cytoarchitecture of the cerebellum. Litter size is reduced by half in mutant females. |
Breeding history | Backcrossed to C57BL/6J background for more than 6 generations. |
References |
|
Homozygous fertile | no |
Homozygous viable | yes |
Homozygous matings required | no |
Immunocompromised | not known |
Information from EMMA
Archiving centre | CNR, Consiglio Nazionale delle Ricerche, Monterotondo, Italy |
Disease and phenotype information
IMPC phenotypes (gene matching)
MGI phenotypes (allele matching)
- decreased litter size / MGI
- shortened circadian behavior period / MGI
- advanced circadian behavior phase / MGI
- increased circulating LDL cholesterol level / MGI
- increased circulating HDL cholesterol level / MGI
- abnormal bile salt homeostasis / MGI
- decreased liver triglyceride level / MGI
- decreased liver cholesterol level / MGI
MGI phenotypes (gene matching)
- increased circulating LDL cholesterol level / MGI
- abnormal cerebellum morphology / MGI
- abnormal cerebellum development / MGI
- abnormal cerebellum external granule cell layer morphology / MGI
- abnormal cerebellar molecular layer / MGI
- decreased body weight / MGI
- increased circulating HDL cholesterol level / MGI
- reduced male fertility / MGI
- reduced female fertility / MGI
- decreased litter size / MGI
- no phenotypic analysis / MGI
- abnormal cerebellar granule cell morphology / MGI
- increased oxygen consumption / MGI
- abnormal bile salt homeostasis / MGI
- increased body temperature / MGI
- abnormal Purkinje cell dendrite morphology / MGI
- abnormal Purkinje cell differentiation / MGI
- decreased liver triglyceride level / MGI
- increased skeletal muscle fiber size / MGI
- abnormal skeletal muscle fiber type ratio / MGI
- decreased sensitivity to induced morbidity/mortality / MGI
- decreased liver cholesterol level / MGI
- increased core body temperature / MGI
- abnormal circadian temperature homeostasis / MGI
- postnatal lethality, incomplete penetrance / MGI
- shortened circadian behavior period / MGI
- advanced circadian behavior phase / MGI
- decreased susceptibility to induced hypothermia / MGI
- increased adipocyte glucose uptake / MGI
Literature references
- The orphan nuclear receptor REV-ERBalpha controls circadian transcription within the positive limb of the mammalian circadian oscillator.;Preitner Nicolas, Damiola Francesca, Lopez-Molina Luis, Zakany Joszef, Duboule Denis, Albrecht Urs, Schibler Ueli, ;2002;Cell;110;251-60; 12150932
- TH17 cell differentiation is regulated by the circadian clock.;Yu Xiaofei, Rollins Darcy, Ruhn Kelly A, Stubblefield Jeremy J, Green Carla B, Kashiwada Masaki, Rothman Paul B, Takahashi Joseph S, Hooper Lora V, ;2013;Science (New York, N.Y.);342;727-30; 24202171
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