B6;129S2-Teftm1Schb/Cnrm
Status | Available to order |
EMMA ID | EM:02486 |
International strain name | B6;129S2-Teftm1Schb/Cnrm |
Alternative name | TEF-KO |
Strain type | Targeted Mutant Strains : Knock-out |
Allele/Transgene symbol | Teftm1Schb |
Gene/Transgene symbol | Tef |
Information from provider
Provider | Ueli Schibler |
Provider affiliation | University of Geneva |
Genetic information | Targeting construct is derived from 129 DNA. A lacZ and PGK-neo replaced exon 2, which encodes the transactivation domain. Western blot indicated absence of protein in the liver of mutants. |
Phenotypic information | Homozygotes Teftm1Schb/Teftm1Schb have spontaneous seizures but less frequent than triple knockout mice (Dbptm1Schb/tm1Schb; Hlftm1Schb/tm1Schb; Teftm1Schb/tm1Schb), spontaneous high-voltage and absence-like seizures, no generalized tonic-clonic epilepsies. |
Breeding history | No backcross but crossed with inbred C57BL/6 mice and then intercrossed. |
References |
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Homozygous fertile | yes |
Homozygous viable | yes |
Homozygous matings required | no |
Immunocompromised | no |
Information from EMMA
Archiving centre | CNR, Consiglio Nazionale delle Ricerche, Monterotondo, Italy |
Disease and phenotype information
Literature references
- The loss of circadian PAR bZip transcription factors results in epilepsy.;Gachon Frédéric, Fonjallaz Philippe, Damiola Francesca, Gos Pascal, Kodama Tohru, Zakany Jozsef, Duboule Denis, Petit Brice, Tafti Mehdi, Schibler Ueli, ;2004;Genes & development;18;1397-412; 15175240
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