MGI phenotypes (allele matching)
B6;129S2-Teftm1Schb/Cnrm
| Status | Available to order |
| EMMA ID | EM:02486 |
| Citation information | RRID:IMSR_EM:02486 Research Resource Identifiers (RRID) are persistent unique ID numbers assigned to help researchers cite key resources (e.g. antibodies, model organisms and software projects) in the biomedical literature to improve transparency and reproducibility in research. See https://www.rrids.org/ for more information. |
| International strain name | B6;129S2-Teftm1Schb/Cnrm |
| Alternative name | TEF-KO |
| Strain type | Targeted Mutant Strains : Knock-out |
| Allele/Transgene symbol | Teftm1Schb |
| Gene/Transgene symbol | Tef |
Information from provider
| Provider | Ueli Schibler |
| Provider affiliation | University of Geneva |
| Genetic information | Targeting construct is derived from 129 DNA. A lacZ and PGK-neo replaced exon 2, which encodes the transactivation domain. Western blot indicated absence of protein in the liver of mutants. |
| Phenotypic information | Homozygotes Teftm1Schb/Teftm1Schb have spontaneous seizures but less frequent than triple knockout mice (Dbptm1Schb/tm1Schb; Hlftm1Schb/tm1Schb; Teftm1Schb/tm1Schb), spontaneous high-voltage and absence-like seizures, no generalized tonic-clonic epilepsies. |
| Breeding history | No backcross but crossed with inbred C57BL/6 mice and then intercrossed. |
| References |
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| Homozygous fertile | yes |
| Homozygous viable | yes |
| Homozygous matings required | no |
| Immunocompromised | no |
Information from EMMA
| Archiving centre | CNR, Consiglio Nazionale delle Ricerche, Monterotondo, Italy |
Disease and phenotype information
Literature references
- The loss of circadian PAR bZip transcription factors results in epilepsy.;Gachon Frédéric, Fonjallaz Philippe, Damiola Francesca, Gos Pascal, Kodama Tohru, Zakany Jozsef, Duboule Denis, Petit Brice, Tafti Mehdi, Schibler Ueli, ;2004;Genes & development;18;1397-412; 15175240