B6;129P2-Dbptm1Schb/Cnrm
Status | Available to order |
EMMA ID | EM:02485 |
International strain name | B6;129P2-Dbptm1Schb/Cnrm |
Alternative name | DBP-KO |
Strain type | Targeted Mutant Strains : Knock-out |
Allele/Transgene symbol | Dbptm1Schb |
Gene/Transgene symbol | Dbp |
Information from provider
Provider | Ueli Schibler |
Provider affiliation | University of Geneva |
Genetic information | A LacZ-neo cassette has been inserted between the BstEII site of exon1 and the end of the exon4, disrupting the entire coding sequence by homologous recombination. |
Phenotypic information | The mice have a shorter circadian period and display less locomotor activity than wild-type. |
Breeding history | No backcross but crossed with inbred C57BL/6 mice and then intercrossed. |
References |
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Homozygous fertile | yes |
Homozygous viable | yes |
Homozygous matings required | no |
Immunocompromised | no |
Information from EMMA
Archiving centre | CNR, Consiglio Nazionale delle Ricerche, Monterotondo, Italy |
Disease and phenotype information
Orphanet associated rare diseases, based on orthologous gene matching
- Perrault syndrome / Orphanet_2855
- Bifunctional enzyme deficiency / Orphanet_300
MGI phenotypes (allele matching)
Literature references
- The DBP gene is expressed according to a circadian rhythm in the suprachiasmatic nucleus and influences circadian behavior.;Lopez-Molina L, Conquet F, Dubois-Dauphin M, Schibler U, ;1997;The EMBO journal;16;6762-71; 9362490
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