MGI phenotypes (allele matching)
B6;129P2-Dbptm1Schb/Cnrm
| Status | Available to order |
| EMMA ID | EM:02485 |
| Citation information | RRID:IMSR_EM:02485 Research Resource Identifiers (RRID) are persistent unique ID numbers assigned to help researchers cite key resources (e.g. antibodies, model organisms and software projects) in the biomedical literature to improve transparency and reproducibility in research. See https://www.rrids.org/ for more information. |
| International strain name | B6;129P2-Dbptm1Schb/Cnrm |
| Alternative name | DBP-KO |
| Strain type | Targeted Mutant Strains : Knock-out |
| Allele/Transgene symbol | Dbptm1Schb |
| Gene/Transgene symbol | Dbp |
Information from provider
| Provider | Ueli Schibler |
| Provider affiliation | University of Geneva |
| Genetic information | A LacZ-neo cassette has been inserted between the BstEII site of exon1 and the end of the exon4, disrupting the entire coding sequence by homologous recombination. |
| Phenotypic information | The mice have a shorter circadian period and display less locomotor activity than wild-type. |
| Breeding history | No backcross but crossed with inbred C57BL/6 mice and then intercrossed. |
| References |
|
| Homozygous fertile | yes |
| Homozygous viable | yes |
| Homozygous matings required | no |
| Immunocompromised | no |
Information from EMMA
| Archiving centre | CNR, Consiglio Nazionale delle Ricerche, Monterotondo, Italy |
Disease and phenotype information
Orphanet associated rare diseases, based on orthologous gene matching
- Perrault syndrome / Orphanet_2855
- Bifunctional enzyme deficiency / Orphanet_300
Literature references
- The DBP gene is expressed according to a circadian rhythm in the suprachiasmatic nucleus and influences circadian behavior.;Lopez-Molina L, Conquet F, Dubois-Dauphin M, Schibler U, ;1997;The EMBO journal;16;6762-71; 9362490