NMRI-Tg(Agt)123Uhg/Cnrm
| Status | Available to order |
| EMMA ID | EM:02484 |
| Citation information | RRID:IMSR_EM:02484 Research Resource Identifiers (RRID) are persistent unique ID numbers assigned to help researchers cite key resources (e.g. antibodies, model organisms and software projects) in the biomedical literature to improve transparency and reproducibility in research. See https://www.rrids.org/ for more information. |
| International strain name | NMRI-Tg(Agt)123Uhg/Cnrm |
| Alternative name | TGM(rAOGEN)102 |
| Strain type | Transgenic Strains |
| Allele/Transgene symbol | Tg(Agt)123Uhg |
| Gene/Transgene symbol | Tg(Agt)123Uhg |
Information from provider
| Provider | Thomas Walther |
| Provider affiliation | Hull York Medical School, University of Hull |
| Genetic information | A genomic rat AOGEN (Agt) clone (pRag15U), including 1.6 kb of 5' flanking sequences, was microinjected into fertilized eggs of NMRI mice as a 14.2 kb linear EcoRI-Hindlll fragment. |
| Phenotypic information | Transgenic mice have elevated plasma levels of angiotensinogen and angiotensin II and have therefore an increased mean arterial pressure. |
| Breeding history | Animals were not backcrossed and are maintained on a NMRI background. |
| References |
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| Homozygous fertile | not known |
| Homozygous viable | not known |
| Homozygous matings required | no |
| Immunocompromised | no |
Information from EMMA
| Archiving centre | CNR, Consiglio Nazionale delle Ricerche, Monterotondo, Italy |
Literature references
- High blood pressure in transgenic mice carrying the rat angiotensinogen gene.;Kimura S, Mullins J J, Bunnemann B, Metzger R, Hilgenfeldt U, Zimmermann F, Jacob H, Fuxe K, Ganten D, Kaling M, ;1992;The EMBO journal;11;821-7; 1547785