IMPC phenotypes (gene matching)
B6;129P2-Bdkrb1tm1Bdr/Cnrm
| Status | Available to order |
| EMMA ID | EM:02482 |
| Citation information | RRID:IMSR_EM:02482 Research Resource Identifiers (RRID) are persistent unique ID numbers assigned to help researchers cite key resources (e.g. antibodies, model organisms and software projects) in the biomedical literature to improve transparency and reproducibility in research. See https://www.rrids.org/ for more information. |
| International strain name | B6;129P2-Bdkrb1tm1Bdr/Cnrm |
| Alternative name | B1 knockout |
| Strain type | Targeted Mutant Strains : Knock-out |
| Allele/Transgene symbol | Bdkrb1tm1Bdr |
| Gene/Transgene symbol | Bdkrb1 |
Information from provider
| Provider | Thomas Walther |
| Provider affiliation | Hull York Medical School, University of Hull |
| Genetic information | The B1-receptor gene (Bdkrb1) was cloned from a genomic library of 129/SvJ mice in lambda FIXII. The targeting vector was generated by flanking the neomycin resistance gene with a 1.0 Kb genomic fragment 5' of the B1-coding region and a 7.0 Kb fragment 3' of the B1-coding region. |
| Phenotypic information | B1-deficient animals are grossly normal, fertile, and normotensive. |
| Breeding history | The line is currently backcrossed to a C57BL/6J background (second generation of backcrossing). |
| References |
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| Homozygous fertile | yes |
| Homozygous viable | yes |
| Homozygous matings required | no |
| Immunocompromised | no |
Information from EMMA
| Archiving centre | CNR, Consiglio Nazionale delle Ricerche, Monterotondo, Italy |
Disease and phenotype information
MGI phenotypes (gene matching)
Literature references
- Hypoalgesia and altered inflammatory responses in mice lacking kinin B1 receptors.;Pesquero J B, Araujo R C, Heppenstall P A, Stucky C L, Silva J A, Walther T, Oliveira S M, Pesquero J L, Paiva A C, Calixto J B, Lewin G R, Bader M, ;2000;Proceedings of the National Academy of Sciences of the United States of America;97;8140-5; 10859349