B6;129P2-Bdnftm1(Ntf3)Pern/Kieg

Status

Available to order

EMMA IDEM:00247
Citation informationRRID:IMSR_EM:00247 

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International strain nameB6;129P2-Bdnftm1(Ntf3)Pern/Kieg
Alternative nameBDNF(NT3/NT3)
Strain typeTargeted Mutant Strains : Knock-in
Allele/Transgene symbolBdnftm1(Ntf3)Pern
Gene/Transgene symbolBdnf

Information from provider

ProviderPatrik Ernfors
Provider affiliationDepartment for Medical Biochemistry and Biophysics, Karolinska Institutet, MBB
Genetic informationExon 5 of the Bdnf gene was disrupted by an in-frame fusion of the Ntf3 (NT3) protein coding sequence and a floxed neo cassette.
Phenotypic informationHomozygous mice die around postnatal day 27. They have defective coordination of balance and movement and lack nerve innervation of the inner ear caused by a loss of neurons in several sensory ganglia.
References
  • BDNF gene replacement reveals multiple mechanisms for establishing neurotrophin specificity during sensory nervous system development.;Agerman Karin, Hjerling-Leffler Jens, Blanchard Marie Pierre, Scarfone Eric, Canlon Barbara, Nosrat Christopher, Ernfors Patrik, ;2003;Development (Cambridge, England);130;1479-91; 12620975
  • Differential influence of BDNF and NT3 on the expression of calcium binding proteins and neuropeptide Y in vivo.;Agerman Karin, Ernfors Patrik, ;2003;Neuroreport;14;2183-7; 14625444

Information from EMMA

Archiving centreKarolinska Institutet, Stockholm, Sweden

Disease and phenotype information

MGI phenotypes (allele matching)
  • abnormal cochlea morphology / MGI
  • abnormal sensory neuron morphology / MGI
  • abnormal sensory neuron innervation pattern / MGI
  • abnormal geniculate ganglion morphology / MGI
  • small nodose ganglion / MGI
  • increased body weight / MGI
  • impaired coordination / MGI
  • impaired balance / MGI
  • premature death / MGI
  • abnormal innervation / MGI
  • abnormal vestibular ganglion morphology / MGI
  • abnormal crista ampullaris morphology / MGI
  • vestibular ganglion degeneration / MGI
  • hearing/vestibular/ear phenotype / MGI
  • abnormal gustatory system morphology / MGI
  • abnormal fungiform papillae morphology / MGI
MGI phenotypes (gene matching)
  • abnormal cochlea morphology / MGI
  • abnormal hair cycle / MGI
  • shortened head / MGI
  • abnormal intestine morphology / MGI
  • abnormal colon morphology / MGI
  • decreased brain size / MGI
  • abnormal dentate gyrus morphology / MGI
  • abnormal cerebellum external granule cell layer morphology / MGI
  • small mesencephalic trigeminal nucleus / MGI
  • abnormal somatic sensory system morphology / MGI
  • abnormal sensory ganglion morphology / MGI
  • abnormal dorsal root ganglion morphology / MGI
  • small dorsal root ganglion / MGI
  • abnormal sensory neuron morphology / MGI
  • decreased sensory neuron number / MGI
  • abnormal sensory neuron innervation pattern / MGI
  • abnormal sympathetic system morphology / MGI
  • small L4 dorsal root ganglion / MGI
  • abnormal adrenergic neuron morphology / MGI
  • abnormal trigeminal nerve morphology / MGI
  • abnormal cranial ganglia morphology / MGI
  • abnormal geniculate ganglion morphology / MGI
  • small geniculate ganglion / MGI
  • small petrosal ganglion / MGI
  • small nodose ganglion / MGI
  • small trigeminal ganglion / MGI
  • increased body weight / MGI
  • obese / MGI
  • decreased body weight / MGI
  • weight loss / MGI
  • decreased body size / MGI
  • increased aggression towards males / MGI
  • increased anxiety-related response / MGI
  • ataxia / MGI
  • circling / MGI
  • hyperactivity / MGI
  • hypoactivity / MGI
  • impaired coordination / MGI
  • head bobbing / MGI
  • spinning / MGI
  • excessive scratching / MGI
  • decreased exploration in new environment / MGI
  • polyphagia / MGI
  • abnormal contextual conditioning behavior / MGI
  • reduced long term potentiation / MGI
  • hunched posture / MGI
  • abnormal motor coordination/balance / MGI
  • impaired righting response / MGI
  • impaired limb coordination / MGI
  • impaired balance / MGI
  • postnatal growth retardation / MGI
  • impaired synaptic plasticity / MGI
  • reduced male fertility / MGI
  • female infertility / MGI
  • deafness / MGI
  • abnormal motor capabilities/coordination/movement / MGI
  • increased circulating insulin level / MGI
  • premature death / MGI
  • no abnormal phenotype detected / MGI
  • abnormal innervation / MGI
  • abnormal CNS synaptic transmission / MGI
  • abnormal nervous system electrophysiology / MGI
  • abnormal keratinocyte morphology / MGI
  • abnormal somatic nervous system morphology / MGI
  • decreased vertical activity / MGI
  • abnormal cochlear ganglion morphology / MGI
  • abnormal vestibular ganglion morphology / MGI
  • abnormal neuron morphology / MGI
  • abnormal excitatory postsynaptic potential / MGI
  • abnormal inhibitory postsynaptic currents / MGI
  • no phenotypic analysis / MGI
  • abnormal neuron apoptosis / MGI
  • increased neuron apoptosis / MGI
  • increased susceptibility to age related obesity / MGI
  • abnormal GABAergic neuron morphology / MGI
  • abnormal locomotor activation / MGI
  • nervous system phenotype / MGI
  • abnormal nervous system physiology / MGI
  • abnormal serotonergic neuron morphology / MGI
  • small vestibular ganglion / MGI
  • abnormal barrel cortex morphology / MGI
  • abnormal striatum morphology / MGI
  • abnormal brain interneuron morphology / MGI
  • abnormal crista ampullaris morphology / MGI
  • vestibular ganglion degeneration / MGI
  • abnormal type I vestibular cell / MGI
  • abnormal vestibular nerve morphology / MGI
  • abnormal cochlear OHC afferent innervation pattern / MGI
  • abnormal neuron physiology / MGI
  • abnormal synaptic plasticity / MGI
  • head tilt / MGI
  • abnormal serotonin level / MGI
  • hearing/vestibular/ear phenotype / MGI
  • abnormal gustatory system morphology / MGI
  • decreased pulmonary respiratory rate / MGI
  • abnormal fungiform papillae morphology / MGI
  • abnormal circumvallate papillae morphology / MGI
  • abnormal gustatory papillae taste bud morphology / MGI
  • abnormal dendrite morphology / MGI
  • increased neuron number / MGI
  • abnormal axon pruning / MGI
  • decreased tongue size / MGI
  • abnormal dendritic spine morphology / MGI
  • abnormal neuron differentiation / MGI
  • postnatal lethality, complete penetrance / MGI
  • postnatal lethality, incomplete penetrance / MGI
  • abnormal colon goblet cell morphology / MGI
  • decreased hippocampus volume / MGI

Literature references

  • BDNF gene replacement reveals multiple mechanisms for establishing neurotrophin specificity during sensory nervous system development.;Agerman Karin, Hjerling-Leffler Jens, Blanchard Marie Pierre, Scarfone Eric, Canlon Barbara, Nosrat Christopher, Ernfors Patrik, ;2003;Development (Cambridge, England);130;1479-91; 12620975
  • Differential influence of BDNF and NT3 on the expression of calcium binding proteins and neuropeptide Y in vivo.;Agerman Karin, Ernfors Patrik, ;2003;Neuroreport;14;2183-7; 14625444

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