- abnormal tooth development / MGI
- brittle teeth / MGI
- disorganized inner root sheath cells / MGI
- syndactyly / MGI
- oligodactyly / MGI
- enlarged sebaceous gland / MGI
- wrinkled skin / MGI
- thick epidermis / MGI
- decreased body weight / MGI
- curly vibrissae / MGI
- short vibrissae / MGI
- absent vibrissae / MGI
- abnormal tooth morphology / MGI
- abnormal pulmonary alveolus morphology / MGI
- reduced enamel thickness / MGI
- abnormal ameloblast morphology / MGI
- abnormal dentin morphology / MGI
- absent enamel / MGI
- abnormal hair shaft morphology / MGI
- abnormal hair cuticle / MGI
- hairless / MGI
- abnormal tooth hard tissue morphology / MGI
- supernumerary teeth / MGI
- abnormal incisor morphology / MGI
- abnormal hair follicle inner root sheath morphology / MGI
- abnormal enamel organ morphology / MGI
- supernumerary molars / MGI
- abnormal tooth color / MGI
- small incisors / MGI
- microdontia / MGI
- abnormal molar cusp morphology / MGI
- fused teeth / MGI
- fused molars / MGI
- short tooth root / MGI
- abnormal Hertwig epithelial root sheath morphology / MGI
CD1.129P2(Cg)-Sp6tm1.1Ibmm/Cnrm
Status | Available to order |
EMMA ID | EM:02450 |
International strain name | CD1.129P2(Cg)-Sp6tm1.1Ibmm/Cnrm |
Alternative name | CD1-Sp6 tm1Ibmm |
Strain type | Targeted Mutant Strains : Knock-out |
Allele/Transgene symbol | Sp6tm1.1Ibmm |
Gene/Transgene symbol | Sp6 |
Information from provider
Provider | Claude Szpirer |
Provider affiliation | ULB-IBMM |
Genetic information | Targeted mutation obtained with a replacement vector that included flanking loxP sites. The mutation was generated using a mouse line expressing Cre in early development (PGK-Cre), resulting in mice lacking the entire Sp6 gene ubiquitously. See the publication mentioned below. |
Phenotypic information | The Sp6 KO mice are nude, lack functional teeth and present limb and lung malformations. They die within the first 5 weeks after birth, most likely as a result of the absence of a functional dentition. Apoptosis misregulation was found in some of the affected organs. |
Breeding history | The mutation was backcrossed for 10 generations on the 2 genetic backgrounds CD1 and C57BL/6. The two lines are bred in parallel. C57BL/6: fertility quite low. |
References |
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Information from EMMA
Archiving centre | CNR, Consiglio Nazionale delle Ricerche, Monterotondo, Italy |
Disease and phenotype information
MGI phenotypes (allele matching)
MGI phenotypes (gene matching)
- abnormal tooth development / MGI
- brittle teeth / MGI
- disorganized inner root sheath cells / MGI
- syndactyly / MGI
- oligodactyly / MGI
- enlarged sebaceous gland / MGI
- wrinkled skin / MGI
- thick epidermis / MGI
- decreased body weight / MGI
- decreased body size / MGI
- curly vibrissae / MGI
- short vibrissae / MGI
- absent vibrissae / MGI
- premature death / MGI
- abnormal tooth morphology / MGI
- no abnormal phenotype detected / MGI
- abnormal pulmonary alveolus morphology / MGI
- reduced enamel thickness / MGI
- abnormal ameloblast morphology / MGI
- abnormal tooth mineralization / MGI
- abnormal dentin morphology / MGI
- delayed tooth eruption / MGI
- absent enamel / MGI
- abnormal hair shaft morphology / MGI
- abnormal hair cuticle / MGI
- hairless / MGI
- abnormal tooth hard tissue morphology / MGI
- supernumerary teeth / MGI
- abnormal incisor morphology / MGI
- supernumerary incisors / MGI
- decreased survivor rate / MGI
- abnormal hair follicle inner root sheath morphology / MGI
- abnormal enamel organ morphology / MGI
- supernumerary molars / MGI
- abnormal tooth color / MGI
- small incisors / MGI
- microdontia / MGI
- abnormal molar cusp morphology / MGI
- fused teeth / MGI
- fused molars / MGI
- short tooth root / MGI
- abnormal Hertwig epithelial root sheath morphology / MGI
Literature references
- The development of several organs and appendages is impaired in mice lacking Sp6.;Hertveldt Valérie, Louryan Stéphane, van Reeth Thierry, Drèze Pierre, van Vooren Pascale, Szpirer Josiane, Szpirer Claude, ;2008;Developmental dynamics : an official publication of the American Association of Anatomists;237;883-92; 18297738
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