CD1.129P2(Cg)-Sp6tm1.1Ibmm/Cnrm

Status

Available to order

EMMA IDEM:02450
Citation informationRRID:IMSR_EM:02450 

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International strain nameCD1.129P2(Cg)-Sp6tm1.1Ibmm/Cnrm
Alternative nameCD1-Sp6 tm1Ibmm
Strain typeTargeted Mutant Strains : Knock-out
Allele/Transgene symbolSp6tm1.1Ibmm
Gene/Transgene symbolSp6

Information from provider

ProviderClaude Szpirer
Provider affiliationULB-IBMM
Genetic informationTargeted mutation obtained with a replacement vector that included flanking loxP sites. The mutation was generated using a mouse line expressing Cre in early development (PGK-Cre), resulting in mice lacking the entire Sp6 gene ubiquitously. See the publication mentioned below.
Phenotypic informationThe Sp6 KO mice are nude, lack functional teeth and present limb and lung malformations. They die within the first 5 weeks after birth, most likely as a result of the absence of a functional dentition. Apoptosis misregulation was found in some of the affected organs.
Breeding historyThe mutation was backcrossed for 10 generations on the 2 genetic backgrounds CD1 and C57BL/6. The two lines are bred in parallel. C57BL/6: fertility quite low.
References
  • The development of several organs and appendages is impaired in mice lacking Sp6.;Hertveldt Valérie, Louryan Stéphane, van Reeth Thierry, Drèze Pierre, van Vooren Pascale, Szpirer Josiane, Szpirer Claude, ;2008;Developmental dynamics : an official publication of the American Association of Anatomists;237;883-92; 18297738

Information from EMMA

Archiving centreCNR, Consiglio Nazionale delle Ricerche, Monterotondo, Italy

Disease and phenotype information

MGI phenotypes (allele matching)
  • abnormal tooth development / MGI
  • brittle teeth / MGI
  • disorganized inner root sheath cells / MGI
  • syndactyly / MGI
  • oligodactyly / MGI
  • enlarged sebaceous gland / MGI
  • wrinkled skin / MGI
  • thick epidermis / MGI
  • decreased body weight / MGI
  • curly vibrissae / MGI
  • short vibrissae / MGI
  • absent vibrissae / MGI
  • abnormal tooth morphology / MGI
  • abnormal pulmonary alveolus morphology / MGI
  • reduced enamel thickness / MGI
  • abnormal ameloblast morphology / MGI
  • abnormal dentin morphology / MGI
  • absent enamel / MGI
  • abnormal hair shaft morphology / MGI
  • abnormal hair cuticle / MGI
  • hairless / MGI
  • abnormal tooth hard tissue morphology / MGI
  • supernumerary teeth / MGI
  • abnormal incisor morphology / MGI
  • abnormal hair follicle inner root sheath morphology / MGI
  • abnormal enamel organ morphology / MGI
  • supernumerary molars / MGI
  • abnormal tooth color / MGI
  • small incisors / MGI
  • microdontia / MGI
  • abnormal molar cusp morphology / MGI
  • fused teeth / MGI
  • fused molars / MGI
  • short tooth root / MGI
  • abnormal Hertwig epithelial root sheath morphology / MGI
MGI phenotypes (gene matching)
  • abnormal tooth development / MGI
  • brittle teeth / MGI
  • disorganized inner root sheath cells / MGI
  • syndactyly / MGI
  • oligodactyly / MGI
  • enlarged sebaceous gland / MGI
  • wrinkled skin / MGI
  • thick epidermis / MGI
  • decreased body weight / MGI
  • decreased body size / MGI
  • curly vibrissae / MGI
  • short vibrissae / MGI
  • absent vibrissae / MGI
  • premature death / MGI
  • abnormal tooth morphology / MGI
  • no abnormal phenotype detected / MGI
  • abnormal pulmonary alveolus morphology / MGI
  • reduced enamel thickness / MGI
  • abnormal ameloblast morphology / MGI
  • abnormal tooth mineralization / MGI
  • abnormal dentin morphology / MGI
  • delayed tooth eruption / MGI
  • absent enamel / MGI
  • abnormal hair shaft morphology / MGI
  • abnormal hair cuticle / MGI
  • hairless / MGI
  • abnormal tooth hard tissue morphology / MGI
  • supernumerary teeth / MGI
  • abnormal incisor morphology / MGI
  • supernumerary incisors / MGI
  • decreased survivor rate / MGI
  • abnormal hair follicle inner root sheath morphology / MGI
  • abnormal enamel organ morphology / MGI
  • supernumerary molars / MGI
  • abnormal tooth color / MGI
  • small incisors / MGI
  • microdontia / MGI
  • abnormal molar cusp morphology / MGI
  • fused teeth / MGI
  • fused molars / MGI
  • short tooth root / MGI
  • abnormal Hertwig epithelial root sheath morphology / MGI

Literature references

  • The development of several organs and appendages is impaired in mice lacking Sp6.;Hertveldt Valérie, Louryan Stéphane, van Reeth Thierry, Drèze Pierre, van Vooren Pascale, Szpirer Josiane, Szpirer Claude, ;2008;Developmental dynamics : an official publication of the American Association of Anatomists;237;883-92; 18297738

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Requesting frozen sperm or embryos is generally advisable wherever possible, in order to minimise the shipment of live mice.

  • Frozen embryos. Delivered in 4 weeks (after paperwork in place). €1740*
  • Frozen sperm. Delivered in 4 weeks (after paperwork in place). €1740*
  • Rederivation of mice from frozen stock, delivery time available upon request . €3880*

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