CD1.129-Sp6tm1Ibmm/Cnrm

Status

Available to order

EMMA IDEM:02449
Citation informationRRID:IMSR_EM:02449 

Research Resource Identifiers (RRID) are persistent unique ID numbers assigned to help researchers cite key resources (e.g. antibodies, model organisms and software projects) in the biomedical literature to improve transparency and reproducibility in research. See https://www.rrids.org/ for more information.

 
International strain nameCD1.129-Sp6tm1Ibmm/Cnrm
Alternative nameSp6.loxp-tm1Ibmm/CD1
Strain typeTargeted Mutant Strains : Conditional mutation
Allele/Transgene symbolSp6tm1Ibmm
Gene/Transgene symbolSp6

Information from provider

ProviderClaude Szpirer
Provider affiliationULB-IBMM
Genetic informationThe Sp6 gene was targeted by a replacement vector where the entire Sp6 gene was flanked by loxP sites (Sp6tm1Ibmm). In this strain, the gene is functional (no excision). This is the parental strain of the mutant where the Sp6 gene has been deleted (Sp6tm1.1Ibmm).
Phenotypic informationThe mice are normal (the Sp6 protein is functional).
Breeding historyThe modified allele was backcrossed for less than 10 generations (CD1)
References
  • The development of several organs and appendages is impaired in mice lacking Sp6.;Hertveldt Valérie, Louryan Stéphane, van Reeth Thierry, Drèze Pierre, van Vooren Pascale, Szpirer Josiane, Szpirer Claude, ;2008;Developmental dynamics : an official publication of the American Association of Anatomists;237;883-92; 18297738
Homozygous fertileyes
Homozygous viableyes
Homozygous matings requiredno
Immunocompromisedno

Information from EMMA

Archiving centreCNR, Consiglio Nazionale delle Ricerche, Monterotondo, Italy

Disease and phenotype information

MGI phenotypes (gene matching)
  • abnormal tooth development / MGI
  • brittle teeth / MGI
  • disorganized inner root sheath cells / MGI
  • syndactyly / MGI
  • oligodactyly / MGI
  • enlarged sebaceous gland / MGI
  • wrinkled skin / MGI
  • thick epidermis / MGI
  • decreased body weight / MGI
  • decreased body size / MGI
  • curly vibrissae / MGI
  • short vibrissae / MGI
  • absent vibrissae / MGI
  • premature death / MGI
  • abnormal tooth morphology / MGI
  • no abnormal phenotype detected / MGI
  • abnormal pulmonary alveolus morphology / MGI
  • reduced enamel thickness / MGI
  • abnormal ameloblast morphology / MGI
  • abnormal tooth mineralization / MGI
  • abnormal dentin morphology / MGI
  • delayed tooth eruption / MGI
  • absent enamel / MGI
  • abnormal hair shaft morphology / MGI
  • abnormal hair cuticle / MGI
  • hairless / MGI
  • abnormal tooth hard tissue morphology / MGI
  • supernumerary teeth / MGI
  • abnormal incisor morphology / MGI
  • supernumerary incisors / MGI
  • decreased survivor rate / MGI
  • abnormal hair follicle inner root sheath morphology / MGI
  • abnormal enamel organ morphology / MGI
  • supernumerary molars / MGI
  • abnormal tooth color / MGI
  • small incisors / MGI
  • microdontia / MGI
  • abnormal molar cusp morphology / MGI
  • fused teeth / MGI
  • fused molars / MGI
  • short tooth root / MGI
  • abnormal Hertwig epithelial root sheath morphology / MGI

Literature references

  • The development of several organs and appendages is impaired in mice lacking Sp6.;Hertveldt Valérie, Louryan Stéphane, van Reeth Thierry, Drèze Pierre, van Vooren Pascale, Szpirer Josiane, Szpirer Claude, ;2008;Developmental dynamics : an official publication of the American Association of Anatomists;237;883-92; 18297738

Information on how we integrate external resources can be found here

Order

Availabilities

Requesting frozen sperm or embryos is generally advisable wherever possible, in order to minimise the shipment of live mice.

  • Frozen embryos. Delivered in 4 weeks (after paperwork in place). €1740*
  • Rederivation of mice from frozen stock, delivery time available upon request . €3880*

Due to the dynamic nature of our processes strain availability may change at short notice. The local repository manager will advise you in these circumstances.

* In addition users have to cover all the shipping costs (including the cost for returning dry-shippers, where applicable).

More details on pricing and delivery times

Practical information

Example health report
(Current health report will be provided later)

Material Transfer Agreement (MTA)
For this strain no provider MTA is needed. Distribution is based on the EMMA conditions only.

EMMA conditions
Legally binding conditions for the transfer

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