- abnormal tooth development / MGI
- brittle teeth / MGI
- disorganized inner root sheath cells / MGI
- syndactyly / MGI
- oligodactyly / MGI
- enlarged sebaceous gland / MGI
- wrinkled skin / MGI
- thick epidermis / MGI
- decreased body weight / MGI
- decreased body size / MGI
- curly vibrissae / MGI
- short vibrissae / MGI
- absent vibrissae / MGI
- premature death / MGI
- abnormal tooth morphology / MGI
- no abnormal phenotype detected / MGI
- abnormal pulmonary alveolus morphology / MGI
- reduced enamel thickness / MGI
- abnormal ameloblast morphology / MGI
- abnormal tooth mineralization / MGI
- abnormal dentin morphology / MGI
- delayed tooth eruption / MGI
- absent enamel / MGI
- abnormal hair shaft morphology / MGI
- abnormal hair cuticle / MGI
- hairless / MGI
- abnormal tooth hard tissue morphology / MGI
- supernumerary teeth / MGI
- abnormal incisor morphology / MGI
- supernumerary incisors / MGI
- decreased survivor rate / MGI
- abnormal hair follicle inner root sheath morphology / MGI
- abnormal enamel organ morphology / MGI
- supernumerary molars / MGI
- abnormal tooth color / MGI
- small incisors / MGI
- microdontia / MGI
- abnormal molar cusp morphology / MGI
- fused teeth / MGI
- fused molars / MGI
- short tooth root / MGI
- abnormal Hertwig epithelial root sheath morphology / MGI
CD1.129-Sp6tm1Ibmm/Cnrm
Status | Available to order |
EMMA ID | EM:02449 |
International strain name | CD1.129-Sp6tm1Ibmm/Cnrm |
Alternative name | Sp6.loxp-tm1Ibmm/CD1 |
Strain type | Targeted Mutant Strains : Conditional mutation |
Allele/Transgene symbol | Sp6tm1Ibmm |
Gene/Transgene symbol | Sp6 |
Information from provider
Provider | Claude Szpirer |
Provider affiliation | ULB-IBMM |
Genetic information | The Sp6 gene was targeted by a replacement vector where the entire Sp6 gene was flanked by loxP sites (Sp6tm1Ibmm). In this strain, the gene is functional (no excision). This is the parental strain of the mutant where the Sp6 gene has been deleted (Sp6tm1.1Ibmm). |
Phenotypic information | The mice are normal (the Sp6 protein is functional). |
Breeding history | The modified allele was backcrossed for less than 10 generations (CD1) |
References |
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Homozygous fertile | yes |
Homozygous viable | yes |
Homozygous matings required | no |
Immunocompromised | no |
Information from EMMA
Archiving centre | CNR, Consiglio Nazionale delle Ricerche, Monterotondo, Italy |
Disease and phenotype information
MGI phenotypes (gene matching)
Literature references
- The development of several organs and appendages is impaired in mice lacking Sp6.;Hertveldt Valérie, Louryan Stéphane, van Reeth Thierry, Drèze Pierre, van Vooren Pascale, Szpirer Josiane, Szpirer Claude, ;2008;Developmental dynamics : an official publication of the American Association of Anatomists;237;883-92; 18297738
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