- small ears / MGI
- kyphosis / MGI
- decreased hair follicle number / MGI
- distorted hair follicle pattern / MGI
- sparse hair / MGI
- abnormal head morphology / MGI
- microcephaly / MGI
- short snout / MGI
- flattened snout / MGI
- abnormal jaw morphology / MGI
- abnormal mandible morphology / MGI
- short limbs / MGI
- abnormal radius morphology / MGI
- syndactyly / MGI
- kinked tail / MGI
- short tail / MGI
- abnormal liver morphology / MGI
- abnormal spleen morphology / MGI
- abnormal tongue morphology / MGI
- shiny skin / MGI
- thin skin / MGI
- abnormal epidermal layer morphology / MGI
- thin epidermis / MGI
- thick epidermis / MGI
- epidermal hyperplasia / MGI
- abnormal epidermis stratum basale morphology / MGI
- abnormal epidermis stratum spinosum morphology / MGI
- abnormal epidermis stratum granulosum morphology / MGI
- abnormal epidermis stratum corneum morphology / MGI
- absent epidermis stratum corneum / MGI
- microphthalmia / MGI
- abnormal eyelid morphology / MGI
- decreased caudal vertebrae number / MGI
- abnormal apical ectodermal ridge morphology / MGI
- postnatal growth retardation / MGI
- decreased IgG level / MGI
- decreased IgM level / MGI
- respiratory failure / MGI
- respiratory distress / MGI
- increased skin papilloma incidence / MGI
- abnormal tail morphology / MGI
- abnormal axial skeleton morphology / MGI
- abnormal B cell differentiation / MGI
- abnormal pharynx morphology / MGI
- abnormal nasal cavity morphology / MGI
- abnormal nasopharynx morphology / MGI
- increased susceptibility to viral infection / MGI
- brachyphalangia / MGI
- abnormal keratinocyte differentiation / MGI
- impaired skin barrier function / MGI
- anal atresia / MGI
- abnormal perineum morphology / MGI
- abnormal eyelid aperture / MGI
- thin lip / MGI
- abnormal craniofacial development / MGI
- abnormal spine curvature / MGI
- increased squamous cell carcinoma incidence / MGI
- small limb buds / MGI
- abnormal embryonic autopod plate morphology / MGI
- decreased B cell number / MGI
- premature hair loss / MGI
- increased B cell proliferation / MGI
- herniated intestine / MGI
- abnormal phalanx morphology / MGI
- craniofacial phenotype / MGI
- immune system phenotype / MGI
- abnormal limb bud morphology / MGI
- abnormal external auditory canal morphology / MGI
- abnormal limb development / MGI
- decreased B-1a cell number / MGI
- decreased follicular B cell number / MGI
- decreased marginal zone B cell number / MGI
- absent spleen marginal zone / MGI
- abnormal spleen B cell follicle morphology / MGI
- increased B cell apoptosis / MGI
- abnormal eyelid fusion / MGI
- abnormal mammary gland epithelium morphology / MGI
- fused lips / MGI
- absent epidermis stratum granulosum / MGI
- oral atresia / MGI
- increased susceptibility to viral infection induced morbidity/mortality / MGI
- palatal shelf fusion with tongue or mandible / MGI
- cleft secondary palate / MGI
- lethality at weaning, incomplete penetrance / MGI
- neonatal lethality, complete penetrance / MGI
- perinatal lethality, complete penetrance / MGI
- flat face / MGI
- small external nares / MGI
- abnormal oral cavity morphology / MGI
- abnormal oral epithelium morphology / MGI
B6.129-Sfntm1.1Hher/Cnrm
Status | Available to order |
EMMA ID | EM:02444 |
International strain name | B6.129-Sfntm1.1Hher/Cnrm |
Alternative name | SFN conditional knock-out |
Strain type | Targeted Mutant Strains : Conditional mutation |
Allele/Transgene symbol | Sfntm1.1Hher |
Gene/Transgene symbol | Sfn |
Information from provider
Provider | Heiko Hermeking |
Provider affiliation | Molekulare Tumorpathologie, Institut für Pathologie |
Additional owner | - |
Genetic information | The targeting construct contains a wild-type Sfn allele plus a Neo-resistance marker, surrounded by frt sites, and the complete cassette is surrounded by LoxP sites. The internal Neo marker was removed by crossing to Flp-expressing mice, leaving a wild-type Sfn allele surrounded by LoxP sites. |
Phenotypic information | When the floxed Sfn allele is removed homozygously, skin inflammation and hair loss in part of the mice; no abnormalities when the floxed allele is in place (also when homozygous). |
Breeding history | Inbred. |
References | None available |
Homozygous fertile | yes |
Homozygous viable | yes |
Homozygous matings required | no |
Immunocompromised | not known |
Information from EMMA
Archiving centre | CNR, Consiglio Nazionale delle Ricerche, Monterotondo, Italy |
Disease and phenotype information
MGI phenotypes (gene matching)
Information on how we integrate external resources can be found here
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