B6.129-Sfntm1.1Hher/Cnrm

Status

Available to order

EMMA IDEM:02444
Citation informationRRID:IMSR_EM:02444 

Research Resource Identifiers (RRID) are persistent unique ID numbers assigned to help researchers cite key resources (e.g. antibodies, model organisms and software projects) in the biomedical literature to improve transparency and reproducibility in research. See https://www.rrids.org/ for more information.

 
International strain nameB6.129-Sfntm1.1Hher/Cnrm
Alternative nameSFN conditional knock-out
Strain typeTargeted Mutant Strains : Conditional mutation
Allele/Transgene symbolSfntm1.1Hher
Gene/Transgene symbolSfn

Information from provider

ProviderHeiko Hermeking
Provider affiliationMolekulare Tumorpathologie, Institut für Pathologie
Additional owner-
Genetic informationThe targeting construct contains a wild-type Sfn allele plus a Neo-resistance marker, surrounded by frt sites, and the complete cassette is surrounded by LoxP sites. The internal Neo marker was removed by crossing to Flp-expressing mice, leaving a wild-type Sfn allele surrounded by LoxP sites.
Phenotypic informationWhen the floxed Sfn allele is removed homozygously, skin inflammation and hair loss in part of the mice; no abnormalities when the floxed allele is in place (also when homozygous).
Breeding historyInbred.
ReferencesNone available
Homozygous fertileyes
Homozygous viableyes
Homozygous matings requiredno
Immunocompromisednot known

Information from EMMA

Archiving centreCNR, Consiglio Nazionale delle Ricerche, Monterotondo, Italy

Disease and phenotype information

MGI phenotypes (gene matching)
  • small ears / MGI
  • kyphosis / MGI
  • decreased hair follicle number / MGI
  • distorted hair follicle pattern / MGI
  • sparse hair / MGI
  • abnormal head morphology / MGI
  • microcephaly / MGI
  • short snout / MGI
  • flattened snout / MGI
  • abnormal jaw morphology / MGI
  • abnormal mandible morphology / MGI
  • short limbs / MGI
  • abnormal radius morphology / MGI
  • syndactyly / MGI
  • kinked tail / MGI
  • short tail / MGI
  • abnormal liver morphology / MGI
  • abnormal spleen morphology / MGI
  • abnormal tongue morphology / MGI
  • shiny skin / MGI
  • thin skin / MGI
  • abnormal epidermal layer morphology / MGI
  • thin epidermis / MGI
  • thick epidermis / MGI
  • epidermal hyperplasia / MGI
  • abnormal epidermis stratum basale morphology / MGI
  • abnormal epidermis stratum spinosum morphology / MGI
  • abnormal epidermis stratum granulosum morphology / MGI
  • abnormal epidermis stratum corneum morphology / MGI
  • absent epidermis stratum corneum / MGI
  • microphthalmia / MGI
  • abnormal eyelid morphology / MGI
  • decreased caudal vertebrae number / MGI
  • abnormal apical ectodermal ridge morphology / MGI
  • postnatal growth retardation / MGI
  • decreased IgG level / MGI
  • decreased IgM level / MGI
  • respiratory failure / MGI
  • respiratory distress / MGI
  • increased skin papilloma incidence / MGI
  • abnormal tail morphology / MGI
  • abnormal axial skeleton morphology / MGI
  • abnormal B cell differentiation / MGI
  • abnormal pharynx morphology / MGI
  • abnormal nasal cavity morphology / MGI
  • abnormal nasopharynx morphology / MGI
  • increased susceptibility to viral infection / MGI
  • brachyphalangia / MGI
  • abnormal keratinocyte differentiation / MGI
  • impaired skin barrier function / MGI
  • anal atresia / MGI
  • abnormal perineum morphology / MGI
  • abnormal eyelid aperture / MGI
  • thin lip / MGI
  • abnormal craniofacial development / MGI
  • abnormal spine curvature / MGI
  • increased squamous cell carcinoma incidence / MGI
  • small limb buds / MGI
  • abnormal embryonic autopod plate morphology / MGI
  • decreased B cell number / MGI
  • premature hair loss / MGI
  • increased B cell proliferation / MGI
  • herniated intestine / MGI
  • abnormal phalanx morphology / MGI
  • craniofacial phenotype / MGI
  • immune system phenotype / MGI
  • abnormal limb bud morphology / MGI
  • abnormal external auditory canal morphology / MGI
  • abnormal limb development / MGI
  • decreased B-1a cell number / MGI
  • decreased follicular B cell number / MGI
  • decreased marginal zone B cell number / MGI
  • absent spleen marginal zone / MGI
  • abnormal spleen B cell follicle morphology / MGI
  • increased B cell apoptosis / MGI
  • abnormal eyelid fusion / MGI
  • abnormal mammary gland epithelium morphology / MGI
  • fused lips / MGI
  • absent epidermis stratum granulosum / MGI
  • oral atresia / MGI
  • increased susceptibility to viral infection induced morbidity/mortality / MGI
  • palatal shelf fusion with tongue or mandible / MGI
  • cleft secondary palate / MGI
  • lethality at weaning, incomplete penetrance / MGI
  • neonatal lethality, complete penetrance / MGI
  • perinatal lethality, complete penetrance / MGI
  • flat face / MGI
  • small external nares / MGI
  • abnormal oral cavity morphology / MGI
  • abnormal oral epithelium morphology / MGI

Information on how we integrate external resources can be found here

Order

Availabilities

Requesting frozen sperm or embryos is generally advisable wherever possible, in order to minimise the shipment of live mice.

  • Frozen embryos. Delivered in 4 weeks (after paperwork in place). €1740*
  • Rederivation of mice from frozen stock, delivery time available upon request . €3880*

Due to the dynamic nature of our processes strain availability may change at short notice. The local repository manager will advise you in these circumstances.

* In addition users have to cover all the shipping costs (including the cost for returning dry-shippers, where applicable).

More details on pricing and delivery times

Practical information

Example health report
(Current health report will be provided later)

Material Transfer Agreement (MTA)
For this strain no provider MTA is needed. Distribution is based on the EMMA conditions only.

EMMA conditions
Legally binding conditions for the transfer

Other EMMA strains

Not found what you were looking for? Search here for other strains available from EMMA.


Search
INFRAFRONTIER® and European Mouse Mutant Archive - EMMA® are registered trademarks at the European Union Intellectual Property Office (EUIPO).