MGI phenotypes (allele matching)
B6.129P2-Prnp/Prndtm1Aag/Cnrm
| Status | Available to order |
| EMMA ID | EM:02432 |
| Citation information | RRID:IMSR_EM:02432 Research Resource Identifiers (RRID) are persistent unique ID numbers assigned to help researchers cite key resources (e.g. antibodies, model organisms and software projects) in the biomedical literature to improve transparency and reproducibility in research. See https://www.rrids.org/ for more information. |
| International strain name | B6.129P2-Prnp/Prndtm1Aag/Cnrm |
| Alternative name | C57Bl/6J-Prnd/PrnP (PrP-Dpl) double knockout mouse |
| Strain type | Targeted Mutant Strains : Knock-out |
| Allele/Transgene symbol | Prnp/Prndtm1Aag |
| Gene/Transgene symbol | Prnd |
Information from provider
| Provider | Adriano Aguzzi |
| Provider affiliation | Univ.Hosp.Zurich/Inst.Neuropathology |
| Additional owner | Dr. Andrew Steele, Whitehead Institute for Biomedical Research, Cambridge MA, USA |
| Genetic information | Large deletion of Prnp and Prnd genes, termed Prn locus deletion. |
| Phenotypic information | Male mice are infertile. |
| Breeding history | Backcrossed to C57BL/6J for 7 generations. |
| References |
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Information from EMMA
| Archiving centre | CNR, Consiglio Nazionale delle Ricerche, Monterotondo, Italy |
Disease and phenotype information
MGI phenotypes (gene matching)
- impaired fertilization / MGI
- male infertility / MGI
- abnormal spermiogenesis / MGI
- asthenozoospermia / MGI
- oligozoospermia / MGI
- nervous system phenotype / MGI
- impaired acrosome reaction / MGI
- behavior/neurological phenotype / MGI
- immune system phenotype / MGI
- teratozoospermia / MGI
- abnormal acrosome morphology / MGI
- abnormal sperm head morphology / MGI
- hairpin sperm flagellum / MGI
Literature references
- Disruption of Doppel prevents neurodegeneration in mice with extensive Prnp deletions.;Genoud Nicolas, Behrens Axel, Miele Gino, Robay Dimitri, Heppner Frank L, Freigang Stefan, Aguzzi Adriano, ;2004;Proceedings of the National Academy of Sciences of the United States of America;101;4198-203; 15007175