CAnNCrl.GFF(CB)-Grhl3ct/Cnrm

Status

Available to order

EMMA IDEM:02425
International strain nameCAnNCrl.GFF(CB)-Grhl3ct/Cnrm
Alternative nameBALB/c - curly tail
Strain typeSpontaneous
Allele/Transgene symbolGrhl3ct
Gene/Transgene symbolGrhl3

Information from provider

ProviderMadeleine BROUNS
Provider affiliationMaastricht University
Genetic informationHypomorphic allele of grainyhead-like 3; exact mutation unknown.
Phenotypic informationHomozygotes display curled tails and/or spina bifida with incomplete penetrance. A small subset of homozygotes displays exencephaly.
Breeding historyHomozygous curly tail mice were crossed with BALB/c inbred mice. Heterozygous offspring was intercrossed. Affected (homozygous) offspring was crossed with BALB/c; 5 crosses with BALB/c were performed according to this scheme (see also PubMed_ID 15678492). The curly tail critical region present in the current strain is 1 megabase.
References
  • Curly tail: a 50-year history of the mouse spina bifida model.;van Straaten H W, Copp A J, ;2001;Anatomy and embryology;203;225-37; 11396850
  • Inositol- and folate-resistant neural tube defects in mice lacking the epithelial-specific factor Grhl-3.;Ting Stephen B, Wilanowski Tomasz, Auden Alana, Hall Mark, Voss Anne K, Thomas Tim, Parekh Vishwas, Cunningham John M, Jane Stephen M, ;2003;Nature medicine;9;1513-9; 14608380
  • Toward positional cloning of the curly tail gene.;Brouns Madeleine R, Peeters Marian C E, Geurts Jan M, Merckx Diane M, Engelen John J, Hekking Johan W M, Terwindt-Rouwenhorst Els A W, Oosterbaan Mariet E A C, Geraedts Joep P M, van Straaten Henny W, ;2005;Birth defects research. Part A, Clinical and molecular teratology;73;154-61; 15678492
  • Increased expression of Grainyhead-like-3 rescues spina bifida in a folate-resistant mouse model.;Gustavsson Peter, Greene Nicholas D E, Lad Dina, Pauws Erwin, de Castro Sandra C P, Stanier Philip, Copp Andrew J, ;2007;Human molecular genetics;16;2640-6; 17720888

Information from EMMA

Archiving centreCNR, Consiglio Nazionale delle Ricerche, Monterotondo, Italy

Disease and phenotype information

Orphanet associated rare diseases, based on orthologous gene matching

IMPC phenotypes (gene matching)
  • increased startle reflex / IMPC
  • increased circulating phosphate level / IMPC
  • increased circulating glucose level / IMPC
  • decreased circulating alkaline phosphatase level / IMPC
  • decreased blood urea nitrogen level / IMPC
  • abnormal eye morphology / IMPC
  • preweaning lethality, complete penetrance / IMPC
  • abnormal retina morphology / IMPC
  • increased circulating amylase level / IMPC
  • increased circulating calcium level / IMPC
  • decreased circulating triglyceride level / IMPC
  • abnormal locomotor activation / IMPC
MGI phenotypes (allele matching)
  • curly tail / MGI
  • exencephaly / MGI
  • spina bifida cystica / MGI
  • spina bifida / MGI
  • abnormal neural tube closure / MGI
  • fetal growth retardation / MGI
  • abnormal dorsal-ventral axis patterning / MGI
  • anencephaly / MGI
  • delayed neural tube closure / MGI
  • open neural tube / MGI
MGI phenotypes (gene matching)
  • cleft palate / MGI
  • abnormal vertebrae morphology / MGI
  • kyphosis / MGI
  • gastrointestinal hemorrhage / MGI
  • abnormal stomach epithelium morphology / MGI
  • abnormal intestine morphology / MGI
  • kinked tail / MGI
  • abnormal brain development / MGI
  • exencephaly / MGI
  • open neural tube / MGI
  • scaly skin / MGI
  • skin lesions / MGI
  • abnormal epidermal layer morphology / MGI
  • thick epidermis / MGI
  • epidermal hyperplasia / MGI
  • abnormal epidermis stratum basale morphology / MGI
  • abnormal epidermis stratum granulosum morphology / MGI
  • abnormal epidermis stratum corneum morphology / MGI
  • eyelids open at birth / MGI
  • excessive scratching / MGI
  • abnormal lipid level / MGI
  • decreased embryo size / MGI
  • abnormal dorsal-ventral axis patterning / MGI
  • anencephaly / MGI
  • neoplasm / MGI
  • abnormal neural tube morphology / MGI
  • no abnormal phenotype detected / MGI
  • delayed neural tube closure / MGI
  • abnormal keratinocyte differentiation / MGI
  • impaired skin barrier function / MGI
  • curly tail / MGI
  • spina bifida / MGI
  • abnormal neural tube closure / MGI
  • abnormal craniofacial development / MGI
  • fetal growth retardation / MGI
  • abnormal vertebral spinous process morphology / MGI
  • absent vertebral arch / MGI
  • split vertebrae / MGI
  • thick epidermis stratum spinosum / MGI
  • increased keratinocyte proliferation / MGI
  • abnormal corneocyte envelope morphology / MGI
  • abnormal palate development / MGI
  • perinatal lethality, complete penetrance / MGI
  • preweaning lethality, complete penetrance / MGI
  • lethality during fetal growth through weaning, complete penetrance / MGI
  • spina bifida cystica / MGI
  • abnormal periderm development / MGI
  • abnormal corneocyte morphology / MGI

Literature references

  • Curly tail: a 50-year history of the mouse spina bifida model.;van Straaten H W, Copp A J, ;2001;Anatomy and embryology;203;225-37; 11396850
  • Inositol- and folate-resistant neural tube defects in mice lacking the epithelial-specific factor Grhl-3.;Ting Stephen B, Wilanowski Tomasz, Auden Alana, Hall Mark, Voss Anne K, Thomas Tim, Parekh Vishwas, Cunningham John M, Jane Stephen M, ;2003;Nature medicine;9;1513-9; 14608380
  • Toward positional cloning of the curly tail gene.;Brouns Madeleine R, Peeters Marian C E, Geurts Jan M, Merckx Diane M, Engelen John J, Hekking Johan W M, Terwindt-Rouwenhorst Els A W, Oosterbaan Mariet E A C, Geraedts Joep P M, van Straaten Henny W, ;2005;Birth defects research. Part A, Clinical and molecular teratology;73;154-61; 15678492
  • Increased expression of Grainyhead-like-3 rescues spina bifida in a folate-resistant mouse model.;Gustavsson Peter, Greene Nicholas D E, Lad Dina, Pauws Erwin, de Castro Sandra C P, Stanier Philip, Copp Andrew J, ;2007;Human molecular genetics;16;2640-6; 17720888

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Availabilities

Requesting frozen sperm or embryos is generally advisable wherever possible, in order to minimise the shipment of live mice.

  • Frozen embryos. Delivered in 4 weeks (after paperwork in place). €1740*
  • Rederivation of mice from frozen stock, delivery time available upon request . €3880*

Due to the dynamic nature of our processes strain availability may change at short notice. The local repository manager will advise you in these circumstances.

* In addition users have to cover all the shipping costs (including the cost for returning dry-shippers, where applicable).

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Practical information

Example health report
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Material Transfer Agreement (MTA)
For this strain no provider MTA is needed. Distribution is based on the EMMA conditions only.

EMMA conditions
Legally binding conditions for the transfer

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