STOCK Axd/Cnrm

Status

Available to order

EMMA IDEM:02424
Citation informationRRID:IMSR_EM:02424 

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International strain nameSTOCK Axd/Cnrm
Alternative nameBALB/c - Axial defects
Strain typeSpontaneous
Allele/Transgene symbolAxd
Gene/Transgene symbolAxd

Information from provider

ProviderMadeleine BROUNS
Provider affiliationMaastricht University
Genetic informationUnknown.
Phenotypic informationAll homozygotes display curled tails and/or spina bifida. 40% of heterozygotes displays curled tails. Homozygous animals have reduced fertility.
Breeding historyRederived heterozygous Axial defects mice were crossed 3 consecutive times with BALB/c while selecting the dominant curled tail phenotype. Genetic background was monitored using polymorphic marker analysis. This speed congenics protocol resulted in 95% BALB/c genetic background as assessed by 63 markers evenly spread over the genome. Currently the strain is bred as a heterozygous line, maintained by crosses with wild type mice of the same genetic background. Heterozygotes are identified by their curled tail phenotype.
References
  • Expression of a new mutation (Axd) causing axial defects in mice correlates with maternal phenotype and age.;Essien F B, Haviland M B, Naidoff A E, ;1990;Teratology;42;183-94; 2218945
  • Maternal methionine supplementation promotes the remediation of axial defects in Axd mouse neural tube mutants.;Essien F B, ;1992;Teratology;45;205-12; 1615430
  • Methionine but not folinic acid or vitamin B-12 alters the frequency of neural tube defects in Axd mutant mice.;Essien F B, Wannberg S L, ;1993;The Journal of nutrition;123;27-34; 8421227

Information from EMMA

Archiving centreCNR, Consiglio Nazionale delle Ricerche, Monterotondo, Italy

Disease and phenotype information

MGI phenotypes (gene matching)
  • decreased cell proliferation / MGI
  • open neural tube / MGI
  • abnormal embryo development / MGI
  • reduced fertility / MGI
  • decreased litter size / MGI
  • abnormal tail morphology / MGI
  • abnormal neural tube morphology / MGI
  • no abnormal phenotype detected / MGI
  • delayed neural tube closure / MGI
  • vestigial tail / MGI
  • curly tail / MGI
  • abnormal neural tube closure / MGI
  • failure of eyelid fusion / MGI
  • delayed eyelid fusion / MGI
  • neonatal lethality, incomplete penetrance / MGI
  • abnormal caudal neuropore morphology / MGI
  • spina bifida cystica / MGI
  • incomplete caudal neuropore closure / MGI

Literature references

  • Expression of a new mutation (Axd) causing axial defects in mice correlates with maternal phenotype and age.;Essien F B, Haviland M B, Naidoff A E, ;1990;Teratology;42;183-94; 2218945
  • Maternal methionine supplementation promotes the remediation of axial defects in Axd mouse neural tube mutants.;Essien F B, ;1992;Teratology;45;205-12; 1615430
  • Methionine but not folinic acid or vitamin B-12 alters the frequency of neural tube defects in Axd mutant mice.;Essien F B, Wannberg S L, ;1993;The Journal of nutrition;123;27-34; 8421227

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Order

Availabilities

Requesting frozen sperm or embryos is generally advisable wherever possible, in order to minimise the shipment of live mice.

  • Frozen embryos. Delivered in 4 weeks (after paperwork in place). €1740*
  • Rederivation of mice from frozen stock, delivery time available upon request . €3880*

Due to the dynamic nature of our processes strain availability may change at short notice. The local repository manager will advise you in these circumstances.

* In addition users have to cover all the shipping costs (including the cost for returning dry-shippers, where applicable).

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Practical information

Example health report
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