strain-details - INFRAFRONTIER

Information from provider

Status	Available to order
EMMA ID	EM:02423
International strain name	B6.DDD1-plt/Orl
Alternative name	paucity of lymph node T cells (plt)
Strain type	Spontaneous
Allele/Transgene symbol	plt
Gene/Transgene symbol	plt

Provider	Hideki Nakano
Provider affiliation	National Institute of Environmental Health Science
Genetic information	Ccl19 and Ccl21a (also called Ccl21-ser) genes are deleted.
Phenotypic information	Migration of Ccr7+ leukocytes including T cells and dendritic cells from blood or peripheral tissues to lymphoid organs is severely impaired in plt/plt mice.
Breeding history	DDD/1-plt mice were backcrossed to C57BL/6 mice for 10 generations in Toho University, Japan; plt mice on C57BL/6 background have been maintained by inbreeding.
References	Gene duplications at the chemokine locus on mouse chromosome 4: multiple strain-specific haplotypes and the deletion of secondary lymphoid-organ chemokine and EBI-1 ligand chemokine genes in the plt mutation.;Nakano H, Gunn M D, ;2001;Journal of immunology (Baltimore, Md. : 1950);166;361-9; 11123313 A novel mutant gene involved in T-lymphocyte-specific homing into peripheral lymphoid organs on mouse chromosome 4.;Nakano H, Mori S, Yonekawa H, Nariuchi H, Matsuzawa A, Kakiuchi T, ;1998;Blood;91;2886-95; 9531599 Mice lacking expression of secondary lymphoid organ chemokine have defects in lymphocyte homing and dendritic cell localization.;Gunn M D, Kyuwa S, Tam C, Kakiuchi T, Matsuzawa A, Williams L T, Nakano H, ;1999;The Journal of experimental medicine;189;451-60; 9927507

Disease and phenotype information

Archiving centre	Institut de Transgenose, INTRAGENE, Orléans, France

MGI allele-associated human disease models

Sjogren's syndrome / DOID:12894

MGI phenotypes (gene matching)

abnormal leukocyte cell number / MGI
abnormal lacrimal gland morphology / MGI
abnormal immune system physiology / MGI
abnormal T cell activation / MGI
increased inflammatory response / MGI
salivary gland inflammation / MGI
abnormal gland morphology / MGI
abnormal lymph node T cell domain morphology / MGI
abnormal spleen red pulp morphology / MGI
abnormal spleen white pulp morphology / MGI
abnormal thymus cortex morphology / MGI
abnormal immune system organ morphology / MGI
abnormal leukocyte migration / MGI
abnormal parotid gland morphology / MGI
abnormal submandibular gland morphology / MGI
increased length of allograft survival / MGI
increased T cell number / MGI
decreased T cell number / MGI
increased susceptibility to autoimmune disorder / MGI
immune system phenotype / MGI
increased memory T cell number / MGI
decreased single-positive T cell number / MGI
lymph node hypoplasia / MGI
small Peyer's patches / MGI
abnormal peripheral lymph node morphology / MGI
abnormal physiological response to xenobiotic / MGI
submandibular gland inflammation / MGI
lacrimal gland inflammation / MGI
parotid gland inflammation / MGI
small thymus medulla / MGI

Literature references

Gene duplications at the chemokine locus on mouse chromosome 4: multiple strain-specific haplotypes and the deletion of secondary lymphoid-organ chemokine and EBI-1 ligand chemokine genes in the plt mutation.;Nakano H, Gunn M D, ;2001;Journal of immunology (Baltimore, Md. : 1950);166;361-9; 11123313
A novel mutant gene involved in T-lymphocyte-specific homing into peripheral lymphoid organs on mouse chromosome 4.;Nakano H, Mori S, Yonekawa H, Nariuchi H, Matsuzawa A, Kakiuchi T, ;1998;Blood;91;2886-95; 9531599
Mice lacking expression of secondary lymphoid organ chemokine have defects in lymphocyte homing and dendritic cell localization.;Gunn M D, Kyuwa S, Tam C, Kakiuchi T, Matsuzawa A, Williams L T, Nakano H, ;1999;The Journal of experimental medicine;189;451-60; 9927507

Information on how we integrate external resources can be found here

Availabilities

Requesting frozen sperm or embryos is generally advisable wherever possible, in order to minimise the shipment of live mice.

Frozen embryos. Delivered in 4 weeks (after paperwork in place). €1740^*

Rederivation of mice from frozen stock, delivery time available upon request . €3880^*

Due to the dynamic nature of our processes strain availability may change at short notice. The local repository manager will advise you in these circumstances.

^* In addition users have to cover all the shipping costs (including the cost for returning dry-shippers, where applicable).

B6.DDD1-plt/Orl

Information from provider

Information from EMMA

Disease and phenotype information

Literature references

Information on how we integrate external resources can be found here

Availabilities

Practical information

Other EMMA strains