B6.DDD1-plt/Orl

Status	Available to order
EMMA ID	EM:02423
Citation information	RRID:IMSR_EM:02423 Research Resource Identifiers (RRID) are persistent unique ID numbers assigned to help researchers cite key resources (e.g. antibodies, model organisms and software projects) in the biomedical literature to improve transparency and reproducibility in research. See https://www.rrids.org/ for more information.
International strain name	B6.DDD1-plt/Orl
Alternative name	paucity of lymph node T cells (plt)
Strain type	Spontaneous
Allele/Transgene symbol	plt
Gene/Transgene symbol	plt

Provider	Hideki Nakano
Provider affiliation	National Institute of Environmental Health Science
Genetic information	Ccl19 and Ccl21a (also called Ccl21-ser) genes are deleted.
Phenotypic information	Migration of Ccr7+ leukocytes including T cells and dendritic cells from blood or peripheral tissues to lymphoid organs is severely impaired in plt/plt mice.
Breeding history	DDD/1-plt mice were backcrossed to C57BL/6 mice for 10 generations in Toho University, Japan; plt mice on C57BL/6 background have been maintained by inbreeding.
References	Gene duplications at the chemokine locus on mouse chromosome 4: multiple strain-specific haplotypes and the deletion of secondary lymphoid-organ chemokine and EBI-1 ligand chemokine genes in the plt mutation.;Nakano H, Gunn M D, ;2001;Journal of immunology (Baltimore, Md. : 1950);166;361-9; 11123313 A novel mutant gene involved in T-lymphocyte-specific homing into peripheral lymphoid organs on mouse chromosome 4.;Nakano H, Mori S, Yonekawa H, Nariuchi H, Matsuzawa A, Kakiuchi T, ;1998;Blood;91;2886-95; 9531599 Mice lacking expression of secondary lymphoid organ chemokine have defects in lymphocyte homing and dendritic cell localization.;Gunn M D, Kyuwa S, Tam C, Kakiuchi T, Matsuzawa A, Williams L T, Nakano H, ;1999;The Journal of experimental medicine;189;451-60; 9927507

Archiving centre	Institut de Transgenose, INTRAGENE, Orléans, France

MGI allele-associated human disease models

MGI phenotypes (gene matching)

Gene duplications at the chemokine locus on mouse chromosome 4: multiple strain-specific haplotypes and the deletion of secondary lymphoid-organ chemokine and EBI-1 ligand chemokine genes in the plt mutation.;Nakano H, Gunn M D, ;2001;Journal of immunology (Baltimore, Md. : 1950);166;361-9; 11123313
A novel mutant gene involved in T-lymphocyte-specific homing into peripheral lymphoid organs on mouse chromosome 4.;Nakano H, Mori S, Yonekawa H, Nariuchi H, Matsuzawa A, Kakiuchi T, ;1998;Blood;91;2886-95; 9531599
Mice lacking expression of secondary lymphoid organ chemokine have defects in lymphocyte homing and dendritic cell localization.;Gunn M D, Kyuwa S, Tam C, Kakiuchi T, Matsuzawa A, Williams L T, Nakano H, ;1999;The Journal of experimental medicine;189;451-60; 9927507

Information from provider