129-Vim^tm1Cba/Orl

Status	Available to order
EMMA ID	EM:02411
Citation information	RRID:IMSR_EM:02411 Research Resource Identifiers (RRID) are persistent unique ID numbers assigned to help researchers cite key resources (e.g. antibodies, model organisms and software projects) in the biomedical literature to improve transparency and reproducibility in research. See https://www.rrids.org/ for more information.
International strain name	129-Vim^tm1Cba/Orl
Alternative name	Vim1/Vim1
Strain type	Targeted Mutant Strains : Knock-out
Allele/Transgene symbol	Vim^tm1Cba
Gene/Transgene symbol	Vim

Information from provider

Provider	Emma Colucci-Guyon
Provider affiliation	Institut Pasteur
Genetic information	Exon 1 of the vimentin gene is interrupted with a LacZ expression cassette, that is in frame with the first 59 codons of the vimentin gene, followed by a TK-neo resistance cassette. This results in a null mutation of the vimentin locus and in a knock-in of the LacZ gene, which allows following the expression pattern of the vimentin gene via detection of the beta-galactosidase activity. The TKneo cassette is kept in the mutated allele.
Phenotypic information	Mice devoid of vimentin develop and reproduce without any obvious defects.
References	Mice lacking vimentin develop and reproduce without an obvious phenotype.;Colucci-Guyon E, Portier M M, Dunia I, Paulin D, Pournin S, Babinet C, ;1994;Cell;79;679-94; 7954832

Information from EMMA

Archiving centre	Institut de Transgenose, INTRAGENE, Orléans, France
Animals used for archiving	homozygous 129S2/SvPas males, homozygous 129S2/SvPas females

Disease and phenotype information

Orphanet associated rare diseases, based on orthologous gene matching

Pulverulent cataract / Orphanet_98984

IMPC phenotypes (gene matching)

increased granulocyte number / IMPC
increased blood uric acid level / IMPC

MGI phenotypes (allele matching)

abnormal vasoconstriction / MGI
abnormal cell morphology / MGI
abnormal cerebellum morphology / MGI
abnormal cerebellar Purkinje cell layer / MGI
Purkinje cell degeneration / MGI
abnormal Purkinje cell morphology / MGI
decreased Purkinje cell number / MGI
increased anxiety-related response / MGI
abnormal locomotor behavior / MGI
hyperactivity / MGI
impaired coordination / MGI
impaired balance / MGI
abnormal vasodilation / MGI
abnormal astrocyte morphology / MGI
abnormal motor learning / MGI
abnormal cell migration / MGI
nervous system phenotype / MGI
decreased mean systemic arterial blood pressure / MGI
embryo phenotype / MGI
cardiovascular system phenotype / MGI
respiratory system phenotype / MGI
reproductive system phenotype / MGI
increased circulating creatinine level / MGI
abnormal cell physiology / MGI
abnormal Purkinje cell dendrite morphology / MGI
increased sensitivity to induced morbidity/mortality / MGI
abnormal blood vessel morphology / MGI
abnormal leukocyte migration / MGI
abnormal leukocyte tethering or rolling / MGI
abnormal leukocyte adhesion / MGI
homeostasis/metabolism phenotype / MGI
cellular phenotype / MGI
immune system phenotype / MGI
abnormal cellular extravasation / MGI

MGI phenotypes (gene matching)

abnormal vasoconstriction / MGI
abnormal angiogenesis / MGI
abnormal cell morphology / MGI
abnormal cerebellum morphology / MGI
abnormal cerebellar Purkinje cell layer / MGI
Purkinje cell degeneration / MGI
abnormal Purkinje cell morphology / MGI
decreased Purkinje cell number / MGI
increased anxiety-related response / MGI
abnormal locomotor behavior / MGI
hyperactivity / MGI
impaired coordination / MGI
impaired balance / MGI
abnormal vasodilation / MGI
abnormal blood vessel morphology / MGI
abnormal astrocyte morphology / MGI
abnormal motor learning / MGI
abnormal cell migration / MGI
abnormal leukocyte migration / MGI
abnormal leukocyte tethering or rolling / MGI
abnormal leukocyte adhesion / MGI
nervous system phenotype / MGI
decreased mean systemic arterial blood pressure / MGI
homeostasis/metabolism phenotype / MGI
embryo phenotype / MGI
cellular phenotype / MGI
cardiovascular system phenotype / MGI
immune system phenotype / MGI
respiratory system phenotype / MGI
reproductive system phenotype / MGI
increased circulating creatinine level / MGI
abnormal cell physiology / MGI
abnormal Purkinje cell dendrite morphology / MGI
increased sensitivity to induced morbidity/mortality / MGI
abnormal cellular extravasation / MGI

Literature references

Mice lacking vimentin develop and reproduce without an obvious phenotype.;Colucci-Guyon E, Portier M M, Dunia I, Paulin D, Pournin S, Babinet C, ;1994;Cell;79;679-94; 7954832

Information on how we integrate external resources can be found here

Order

Availabilities

Requesting frozen sperm or embryos is generally advisable wherever possible, in order to minimise the shipment of live mice.

Frozen embryos. Delivered in 4 weeks (after paperwork in place). €1740^*
Rederivation of mice from frozen stock, delivery time available upon request . €3880^*

Due to the dynamic nature of our processes strain availability may change at short notice. The local repository manager will advise you in these circumstances.

^* In addition users have to cover all the shipping costs (including the cost for returning dry-shippers, where applicable).

More details on pricing and delivery times

Practical information

Genotyping protocol

Example health report
(Current health report will be provided later)

Material Transfer Agreement (MTA)
Distribution of this strain is subject to a provider MTA. Both signing of the MTA and submission of the online EMMA Mutant Request Form are required before material can be shipped.

EMMA conditions
Legally binding conditions for the transfer

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129-Vimtm1Cba/Orl