IMPC phenotypes (allele matching)
129-Vimtm2Cba/Orl
| Status | Available to order |
| EMMA ID | EM:02410 |
| International strain name | 129-Vimtm2Cba/Orl |
| Alternative name | Vim2/Vim2 |
| Strain type | Targeted Mutant Strains : Knock-out |
| Allele/Transgene symbol | Vimtm2Cba |
| Gene/Transgene symbol | Vim |
Information from provider
| Provider | Emma Colucci-Guyon |
| Provider affiliation | Institut Pasteur |
| Genetic information | Exon 1 of the vimentin gene is disrupted by insertion of a TK-neo expression cassette, which results in the inactivation of the gene. The TKneo expression cassette is kept in the mutated allele. |
| Phenotypic information | Mice devoid of vimentin develop and reproduce without any obvious defects. |
| References |
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Information from EMMA
| Archiving centre | Institut de Transgenose, INTRAGENE, Orléans, France |
Disease and phenotype information
Orphanet associated rare diseases, based on orthologous gene matching
- Pulverulent cataract / Orphanet_98984
MGI phenotypes (gene matching)
- abnormal vasoconstriction / MGI
- abnormal angiogenesis / MGI
- abnormal cell morphology / MGI
- abnormal cerebellum morphology / MGI
- abnormal cerebellar Purkinje cell layer / MGI
- Purkinje cell degeneration / MGI
- abnormal Purkinje cell morphology / MGI
- decreased Purkinje cell number / MGI
- increased anxiety-related response / MGI
- abnormal locomotor behavior / MGI
- hyperactivity / MGI
- impaired coordination / MGI
- impaired balance / MGI
- abnormal vasodilation / MGI
- abnormal blood vessel morphology / MGI
- abnormal astrocyte morphology / MGI
- abnormal motor learning / MGI
- abnormal cell migration / MGI
- abnormal leukocyte migration / MGI
- abnormal leukocyte tethering or rolling / MGI
- abnormal leukocyte adhesion / MGI
- nervous system phenotype / MGI
- decreased mean systemic arterial blood pressure / MGI
- homeostasis/metabolism phenotype / MGI
- embryo phenotype / MGI
- cellular phenotype / MGI
- cardiovascular system phenotype / MGI
- immune system phenotype / MGI
- respiratory system phenotype / MGI
- reproductive system phenotype / MGI
- increased circulating creatinine level / MGI
- abnormal cell physiology / MGI
- abnormal Purkinje cell dendrite morphology / MGI
- increased sensitivity to induced morbidity/mortality / MGI
- abnormal cellular extravasation / MGI
Literature references
- Mice lacking vimentin develop and reproduce without an obvious phenotype.;Colucci-Guyon E, Portier M M, Dunia I, Paulin D, Pournin S, Babinet C, ;1994;Cell;79;679-94; 7954832