B6;129-Grem1^tm1Azun/Cnrm

Status	Available to order
EMMA ID	EM:02399
Citation information	RRID:IMSR_EM:02399 Research Resource Identifiers (RRID) are persistent unique ID numbers assigned to help researchers cite key resources (e.g. antibodies, model organisms and software projects) in the biomedical literature to improve transparency and reproducibility in research. See https://www.rrids.org/ for more information.
International strain name	B6;129-Grem1^tm1Azun/Cnrm
Alternative name	Grem1 delta-Zllr
Strain type	Targeted Mutant Strains : Knock-out
Allele/Transgene symbol	Grem1^tm1Azun
Gene/Transgene symbol	Grem1

Information from provider

Provider	Rolf Zeller
Provider affiliation	DBM Centre for Biomedicine
Genetic information	The entire 552-bases ORF encoded by exon 2 and 132 bases of the 3' UTR were deleted and replaced by an IRES-lacZ and a floxed neo. For details see: Michos O., Panman L., Vintersten K., Beier K., Zeller R. and Zuniga A. (2004). Gremlin mediated BMP antagonism induces the epithelial-mesenchymal feedback signaling controlling metanephric kidney and limb organogenesis. Development 131, 3401-3410.
Phenotypic information	Loss of digit identities, lung epithelial defects, bilateral renal aplasia.
References	Gremlin-mediated BMP antagonism induces the epithelial-mesenchymal feedback signaling controlling metanephric kidney and limb organogenesis.;Michos Odyssé, Panman Lia, Vintersten Kristina, Beier Konstantin, Zeller Rolf, Zuniga Aimée, ;2004;Development (Cambridge, England);131;3401-10; 15201225 Reduction of BMP4 activity by gremlin 1 enables ureteric bud outgrowth and GDNF/WNT11 feedback signalling during kidney branching morphogenesis.;Michos Odyssé, Gonçalves Alexandre, Lopez-Rios Javier, Tiecke Eva, Naillat Florence, Beier Konstantin, Galli Antonella, Vainio Seppo, Zeller Rolf, ;2007;Development (Cambridge, England);134;2397-405; 17522159

Information from EMMA

Archiving centre	CNR, Consiglio Nazionale delle Ricerche, Monterotondo, Italy

Disease and phenotype information

Orphanet associated rare diseases, based on orthologous gene matching

Hereditary mixed polyposis syndrome / Orphanet_157794

MGI phenotypes (allele matching)

absent kidney / MGI
single kidney / MGI
abnormal urinary bladder morphology / MGI
oligodactyly / MGI
cyanosis / MGI
abnormal apical ectodermal ridge morphology / MGI
respiratory distress / MGI
abnormal pulmonary alveolus morphology / MGI
absent ureter / MGI
fused metacarpal bones / MGI
impaired branching involved in ureteric bud morphogenesis / MGI
increased apoptosis / MGI
abnormal limb development / MGI
abnormal lung epithelium morphology / MGI
abnormal ureteric bud elongation / MGI
abnormal ureteric bud invasion / MGI
abnormal metanephric mesenchyme morphology / MGI
neonatal lethality, complete penetrance / MGI
abnormal limb mesenchyme morphology / MGI
absent metanephros / MGI
increased metanephric mesenchyme apoptosis / MGI
abnormal limb long bone morphology / MGI

MGI phenotypes (gene matching)

absent kidney / MGI
abnormal urinary bladder morphology / MGI
abnormal forelimb morphology / MGI
abnormal hindlimb morphology / MGI
abnormal tibia morphology / MGI
syndactyly / MGI
oligodactyly / MGI
cyanosis / MGI
abnormal apical ectodermal ridge morphology / MGI
respiratory distress / MGI
abnormal limb morphology / MGI
abnormal digit morphology / MGI
abnormal kidney morphology / MGI
abnormal fibula morphology / MGI
abnormal pulmonary alveolus morphology / MGI
renal hypoplasia / MGI
single kidney / MGI
absent ureter / MGI
abnormal long bone morphology / MGI
fused metacarpal bones / MGI
impaired branching involved in ureteric bud morphogenesis / MGI
renal/urinary system phenotype / MGI
reproductive system phenotype / MGI
abnormal limb bud morphology / MGI
increased apoptosis / MGI
abnormal limb development / MGI
abnormal lung epithelium morphology / MGI
abnormal ureteric bud elongation / MGI
abnormal ureteric bud invasion / MGI
abnormal metanephric mesenchyme morphology / MGI
postnatal lethality, complete penetrance / MGI
neonatal lethality, complete penetrance / MGI
abnormal limb mesenchyme morphology / MGI
absent metanephros / MGI
increased metanephric mesenchyme apoptosis / MGI
abnormal limb long bone morphology / MGI
fused radius and ulna / MGI

Literature references

Gremlin-mediated BMP antagonism induces the epithelial-mesenchymal feedback signaling controlling metanephric kidney and limb organogenesis.;Michos Odyssé, Panman Lia, Vintersten Kristina, Beier Konstantin, Zeller Rolf, Zuniga Aimée, ;2004;Development (Cambridge, England);131;3401-10; 15201225
Reduction of BMP4 activity by gremlin 1 enables ureteric bud outgrowth and GDNF/WNT11 feedback signalling during kidney branching morphogenesis.;Michos Odyssé, Gonçalves Alexandre, Lopez-Rios Javier, Tiecke Eva, Naillat Florence, Beier Konstantin, Galli Antonella, Vainio Seppo, Zeller Rolf, ;2007;Development (Cambridge, England);134;2397-405; 17522159

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Requesting frozen sperm or embryos is generally advisable wherever possible, in order to minimise the shipment of live mice.

Frozen embryos. Delivered in 4 weeks (after paperwork in place). €1740^*
Frozen sperm. Delivered in 4 weeks (after paperwork in place). €1740^*
Rederivation of mice from frozen stock, delivery time available upon request . €3880^*

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Practical information

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Legally binding conditions for the transfer

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B6;129-Grem1tm1Azun/Cnrm