B6N;D2-Tg(Ggt1-cre/ERT2)1Pepe/Cnrm
| Status | Available to order |
| EMMA ID | EM:02393 |
| International strain name | B6N;D2-Tg(Ggt1-cre/ERT2)1Pepe/Cnrm |
| Alternative name | GGT::Cre-ER T2 |
| Strain type | Transgenic Strains |
| Allele/Transgene symbol | Tg(Ggt1-cre/ERT2)1Pepe |
| Gene/Transgene symbol | Tg(Ggt1-cre/ERT2)1Pepe |
Information from provider
| Provider | Bernd Dworniczak |
| Provider affiliation | University Clinics Muenster |
| Additional owner | Dr. Petra Pennekamp, Institute of Human Genetics, Münster, Germany and Prof. Pierre Chambon, Institut Clinque de la Souris and IGBMC, Illkirch, France |
| Genetic information | Described in detail in: Dworniczak B, Skryabin B, Tchinda J, Heuck S, Seesing FJ, Metzger D, Chambon P, Horst J, Pennekamp P. Inducible Cre/loxP recombination in the mouse proximal tubule. Nephron Exp Nephrol. 2007;106(1):e11-20. Epub 2007 Mar 12. |
| Phenotypic information | None. |
| Breeding history | Founder animal was backcrossed to C57BL/6N. Transgenic animals were used as long as possible for breeding to minimize the chance of silencing of the transgene in advanced generations. |
| References |
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Information from EMMA
| Archiving centre | CNR, Consiglio Nazionale delle Ricerche, Monterotondo, Italy |
Literature references
- Inducible Cre/loxP recombination in the mouse proximal tubule.;Dworniczak Bernd, Skryabin Boris, Tchinda Joëlle, Heuck Silke, Seesing Franz-Josef, Metzger Daniel, Chambon Pierre, Horst Jürgen, Pennekamp Petra, ;2007;Nephron. Experimental nephrology;106;e11-20; 17356303
- Low TGFβ1 expression prevents and high expression exacerbates diabetic nephropathy in mice.;Hathaway Catherine K, Gasim Adil M H, Grant Ruriko, Chang Albert S, Kim Hyung-Suk, Madden Victoria J, Bagnell C Robert, Jennette J Charles, Smithies Oliver, Kakoki Masao, ;2015;Proceedings of the National Academy of Sciences of the United States of America;112;5815-20; 25902541