IMPC phenotypes (gene matching)
B6.129P2(SJL)-Gjb4tm1Kwi/Cnrm
| Status | Available to order |
| EMMA ID | EM:02383 |
| Citation information | RRID:IMSR_EM:02383 Research Resource Identifiers (RRID) are persistent unique ID numbers assigned to help researchers cite key resources (e.g. antibodies, model organisms and software projects) in the biomedical literature to improve transparency and reproducibility in research. See https://www.rrids.org/ for more information. |
| International strain name | B6.129P2(SJL)-Gjb4tm1Kwi/Cnrm |
| Alternative name | Cx30.3LacZ |
| Strain type | Targeted Mutant Strains : Knock-out |
| Allele/Transgene symbol | Gjb4tm1Kwi |
| Gene/Transgene symbol | Gjb4 |
Information from provider
| Provider | Klaus WILLECKE |
| Provider affiliation | Molekulargenetik, Institut fuer Genetik, Universitaet Bonn |
| Genetic information | Instead of the whole open reading frame of exon 2 of Gjb4 (Cx30.3), the coding region of the reporter gene LacZ is inserted. One frt site, 3' of the poly(A)-signal, is remaining in the genome, upon deletion of the frt-flanked neomycin selection cassette. |
| Phenotypic information | Reduced knock-out survival. |
| Breeding history | After blastocyst injection the chimeras were bred with C57BL/6NCrl to obtain brown offspring. This brown offspring was backcrossed once with flp recombinase deleter mice (nearly 100% C57BL/6NCrl) to delete the selection cassette and after that more than two times with C57BL/6NCrl. |
| References |
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Information from EMMA
| Archiving centre | CNR, Consiglio Nazionale delle Ricerche, Monterotondo, Italy |
| Breeding at archiving centre | Backcrossed to C57BL/6J |
Disease and phenotype information
Orphanet associated rare diseases, based on orthologous gene matching
- Erythrokeratodermia variabilis / Orphanet_317
MGI phenotypes (allele matching)
- impaired olfaction / MGI
MGI phenotypes (gene matching)
- impaired olfaction / MGI
Literature references
- Characterization of connexin30.3-deficient mice suggests a possible role of connexin30.3 in olfaction.;Zheng-Fischhöfer Qingyi, Schnichels Marc, Dere Ekrem, Strotmann Jörg, Loscher Nadine, McCulloch Fiona, Kretz Markus, Degen Joachim, Reucher Harald, Nagy James I, Peti-Peterdi Janos, Huston Joseph P, Breer Heinz, Willecke Klaus, ;2007;European journal of cell biology;86;683-700; 17728008