B6;129P2-Esr2tm1Dgen/H

Status

Available to order

EMMA IDEM:02368
International strain nameB6;129P2-Esr2tm1Dgen/H
Alternative nameDELTAGEN_T681
Strain typeTargeted Mutant Strains : Knock-out
Allele/Transgene symbolEsr2tm1Dgen
Gene/Transgene symbolEsr2

Information from provider

Provider Deltagen Inc.
Provider affiliationDeltagen Inc.
Phenotypic informationThere were no significant differences detected in the homozygous mutant mice when compared with age and gender-matched wild-type control mice.
ReferencesNone available

Information from EMMA

Archiving centreMary Lyon Centre at MRC Harwell, Oxford, United Kingdom

Disease and phenotype information

Orphanet associated rare diseases, based on orthologous gene matching

IMPC phenotypes (gene matching)
  • decreased lymphocyte cell number / IMPC
  • increased circulating serum albumin level / IMPC
  • thin ventricular wall / IMPC
  • decreased leukocyte cell number / IMPC
  • decreased lean body mass / IMPC
  • decreased bone mineral content / IMPC
  • increased total body fat amount / IMPC
  • decreased bone mineral density / IMPC
MGI phenotypes (gene matching)
  • abnormal bone marrow cell number / MGI
  • increased leukocyte cell number / MGI
  • increased neutrophil cell number / MGI
  • increased monocyte cell number / MGI
  • enlarged heart / MGI
  • abnormal myocardial fiber morphology / MGI
  • increased bone marrow cell number / MGI
  • increased granulocyte number / MGI
  • altered response to myocardial infarction / MGI
  • accelerated hair follicle regression / MGI
  • abnormal enterocyte morphology / MGI
  • abnormal urinary bladder morphology / MGI
  • abnormal urinary bladder urothelium morphology / MGI
  • enlarged liver / MGI
  • enlarged spleen / MGI
  • spleen hyperplasia / MGI
  • spleen hypoplasia / MGI
  • enlarged lymph nodes / MGI
  • decreased brain size / MGI
  • abnormal substantia nigra morphology / MGI
  • abnormal somatosensory cortex morphology / MGI
  • impaired ovarian folliculogenesis / MGI
  • abnormal ovarian follicle morphology / MGI
  • absent mature ovarian follicles / MGI
  • absent corpus luteum / MGI
  • prostate gland epithelial hyperplasia / MGI
  • abnormal lung morphology / MGI
  • thin epidermis / MGI
  • increased body length / MGI
  • increased body weight / MGI
  • increased aggression towards males / MGI
  • increased anxiety-related response / MGI
  • hypoactivity / MGI
  • decreased exploration in new environment / MGI
  • abnormal spatial learning / MGI
  • reduced long term potentiation / MGI
  • anemia / MGI
  • cardiac hypertrophy / MGI
  • increased circulating luteinizing hormone level / MGI
  • mammary gland alveolar hyperplasia / MGI
  • reduced female fertility / MGI
  • male infertility / MGI
  • female infertility / MGI
  • abnormal estrous cycle / MGI
  • abnormal ovulation / MGI
  • decreased litter size / MGI
  • no abnormal phenotype detected / MGI
  • abnormal astrocyte morphology / MGI
  • abnormal germ cell morphology / MGI
  • abnormal pulmonary alveolus morphology / MGI
  • abnormal lymphopoiesis / MGI
  • abnormal B cell number / MGI
  • abnormal sexual interaction / MGI
  • decreased corpora lutea number / MGI
  • abnormal nociception after inflammation / MGI
  • decreased vertical activity / MGI
  • increased thigmotaxis / MGI
  • colitis / MGI
  • increased heart weight / MGI
  • increased systemic arterial blood pressure / MGI
  • increased insulin sensitivity / MGI
  • abnormal bone mineralization / MGI
  • delayed wound healing / MGI
  • abnormal excitatory postsynaptic potential / MGI
  • no phenotypic analysis / MGI
  • increased vasoconstriction / MGI
  • abnormal long bone epiphyseal plate morphology / MGI
  • decreased insulin secretion / MGI
  • increased erythrocyte cell number / MGI
  • increased pre-B cell number / MGI
  • neuron degeneration / MGI
  • astrocytosis / MGI
  • decreased ovulation rate / MGI
  • nervous system phenotype / MGI
  • abnormal response/metabolism to endogenous compounds / MGI
  • abnormal muscle electrophysiology / MGI
  • increased bone strength / MGI
  • long femur / MGI
  • short ulna / MGI
  • altered response of heart to induced stress / MGI
  • enlarged myocardial fiber / MGI
  • increased circulating insulin-like growth factor I level / MGI
  • abnormal auditory brainstem response / MGI
  • abnormal cochlear IHC afferent innervation pattern / MGI
  • abnormal surfactant physiology / MGI
  • abnormal large intestine crypts of Lieberkuhn morphology / MGI
  • abnormal synaptic plasticity / MGI
  • abnormal behavior / MGI
  • increased osteoblast cell number / MGI
  • ascites / MGI
  • renal/urinary system phenotype / MGI
  • homeostasis/metabolism phenotype / MGI
  • digestive/alimentary phenotype / MGI
  • cardiovascular system phenotype / MGI
  • behavior/neurological phenotype / MGI
  • immune system phenotype / MGI
  • respiratory system phenotype / MGI
  • reproductive system phenotype / MGI
  • skeleton phenotype / MGI
  • abnormal leukopoiesis / MGI
  • increased chronic myelocytic leukemia incidence / MGI
  • hyporesponsive to tactile stimuli / MGI
  • increased circulating glucose level / MGI
  • decreased circulating glucose level / MGI
  • increased vasodilation / MGI
  • abnormal vascular smooth muscle morphology / MGI
  • abnormal vascular smooth muscle physiology / MGI
  • abnormal muscle contractility / MGI
  • decreased dopamine level / MGI
  • abnormal intercalated disk morphology / MGI
  • abnormal mammary gland growth during pregnancy / MGI
  • abnormal mammary gland growth during lactation / MGI
  • dilated heart ventricle / MGI
  • increased pro-B cell number / MGI
  • increased megakaryocyte cell number / MGI
  • abnormal bone ossification / MGI
  • decreased chemical nociceptive threshold / MGI
  • abnormal neocortex morphology / MGI
  • abnormal hair cycle catagen phase / MGI
  • anovulation / MGI
  • decreased physiological sensitivity to xenobiotic / MGI
  • abnormal enterocyte physiology / MGI
  • abnormal enterocyte proliferation / MGI
  • abnormal enterocyte apoptosis / MGI
  • decreased neuron number / MGI
  • enlarged pancreatic islets / MGI
  • abnormal primary ovarian follicle morphology / MGI
  • abnormal secondary ovarian follicle morphology / MGI
  • abnormal mature ovarian follicle morphology / MGI
  • abnormal cumulus oophorus / MGI
  • impaired contextual conditioning behavior / MGI
  • impaired cued conditioning behavior / MGI
  • abnormal mammary gland epithelium morphology / MGI
  • increased keratinocyte apoptosis / MGI
  • urinary bladder inflammation / MGI
  • abnormal superovulation / MGI
  • increased sensitivity to induced morbidity/mortality / MGI
  • increased total body fat amount / MGI
  • decreased serotonin level / MGI
  • abnormal urinary bladder physiology / MGI
  • increased compact bone area / MGI
  • increased urine glycosaminoglycan level / MGI
  • myelofibrosis / MGI
  • decreased volumetric bone mineral density / MGI

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Order

Availabilities

Requesting frozen sperm or embryos is generally advisable wherever possible, in order to minimise the shipment of live mice.

  • Frozen embryos. Delivered in 4 weeks (after paperwork in place). €1740*
  • Rederivation of mice from frozen stock, delivery time available upon request . €3880*
  • Tissue - Types of tissue, service fee and delivery time available upon request

Due to the dynamic nature of our processes strain availability may change at short notice. The local repository manager will advise you in these circumstances.

* In addition users have to cover all the shipping costs (including the cost for returning dry-shippers, where applicable).

More details on pricing and delivery times

Practical information

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