MGI phenotypes (allele matching)
B6;129P2-Grm1tm1Dgen/H
| Status | Available to order |
| EMMA ID | EM:02357 |
| International strain name | B6;129P2-Grm1tm1Dgen/H |
| Alternative name | DELTAGEN_T801 |
| Strain type | Targeted Mutant Strains : Knock-out |
| Allele/Transgene symbol | Grm1tm1Dgen |
| Gene/Transgene symbol | Grm1 |
Information from provider
| Provider | Deltagen Inc. |
| Provider affiliation | Deltagen Inc. |
| Phenotypic information | Home cage observations: ataxia/lack of coordination, stumbling, paddling movements, hypoactivity, thin, and/or hunched posture, 20 and 49 day cohorts. Physical examination: ataxia, incoordination, runted, thinness and weakness in homozygous mutant mice, 49 day cohort. Necropsy examination: decreased body weights and body lengths in homozygous mutant mice at 49 days. Mouse metrics: decreased body weight, body length, and body weight/body length ratio in a homozygous mutant mouse, 49 day cohort. Juvenile lethality: homozygous mutant mice do not survive to 90 day cohort. There were no significant differences detected in the heterozygous mutant mice when compared with age- and gender-matched wild-type control mice. |
| References | None available |
Information from EMMA
| Archiving centre | Mary Lyon Centre at MRC Harwell, Oxford, United Kingdom |
Disease and phenotype information
Orphanet associated rare diseases, based on orthologous gene matching
- Autosomal recessive congenital cerebellar ataxia due to MGLUR1 deficiency / Orphanet_324262
MGI phenotypes (gene matching)
- increased brown adipose tissue amount / MGI
- decreased bone mineral density / MGI
- kyphoscoliosis / MGI
- kyphosis / MGI
- muscle spasm / MGI
- tremors / MGI
- weakness / MGI
- decreased body weight / MGI
- decreased body size / MGI
- abnormal maternal nurturing / MGI
- ataxia / MGI
- hypoactivity / MGI
- abnormal gait / MGI
- decreased exploration in new environment / MGI
- abnormal spatial learning / MGI
- abnormal contextual conditioning behavior / MGI
- reduced long term potentiation / MGI
- reduced long term depression / MGI
- hunched posture / MGI
- limb grasping / MGI
- impaired righting response / MGI
- impaired limb coordination / MGI
- impaired balance / MGI
- reduced fertility / MGI
- reduced female fertility / MGI
- male infertility / MGI
- premature death / MGI
- abnormal fertility/fecundity / MGI
- abnormal nervous system electrophysiology / MGI
- abnormal sexual interaction / MGI
- albuminuria / MGI
- abnormal excitatory postsynaptic currents / MGI
- nervous system phenotype / MGI
- abnormal proximal convoluted tubule morphology / MGI
- increased susceptibility to injury / MGI
- glomerulosclerosis / MGI
- narrow eye opening / MGI
- abnormal podocyte morphology / MGI
- behavior/neurological phenotype / MGI
- podocyte foot process effacement / MGI
- decreased bone mineral content / MGI
- abnormal renal glomerulus basement membrane morphology / MGI
- renal cast / MGI
- increased renal glomerulus basement membrane thickness / MGI
- abnormal glomerular filtration barrier function / MGI
- abnormal electroretinogram waveform feature / MGI