B6;129S5-Kcnb2tm1Lex/Ieg

Status

Available to order

EMMA IDEM:02354
International strain nameB6;129S5-Kcnb2tm1Lex/Ieg
Alternative nameLEXKO-1551, CHA385N1
Strain typeTargeted Mutant Strains : Knock-out
Allele/Transgene symbolKcnb2tm1Lex
Gene/Transgene symbolKcnb2

Information from provider

Provider Lexicon Genetics, Inc.
Provider affiliationLexicon Pharmaceuticals
Phenotypic informationThe homozygous mutant mice exhibited numerous neurological abnormalities when compared with their wild-type littermates and the historical means, including an abnormal sleep/wake cycle, decreased exploratory and locomotor activity, and a motor strength deficit.
ReferencesNone available

Information from EMMA

Archiving centreHelmholtz Zentrum Muenchen - German Research Center for Environmental Health (GmbH), Oberschleißheim, Germany
Animals used for archivingheterozygous C57BL/6J, wild-type C57BL/6J
Stage of embryos2-cell

Disease and phenotype information

IMPC phenotypes (gene matching)
  • hyperactivity / IMPC
  • increased circulating bilirubin level / IMPC
  • decreased hematocrit / IMPC
  • increased circulating alanine transaminase level / IMPC
  • decreased erythrocyte cell number / IMPC
MGI phenotypes (allele matching)
  • weakness / MGI
  • hypoactivity / MGI
  • decreased exploration in new environment / MGI
  • abnormal sleep pattern / MGI
MGI phenotypes (gene matching)
  • weakness / MGI
  • hypoactivity / MGI
  • decreased exploration in new environment / MGI
  • abnormal sleep pattern / MGI

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Order

Availabilities

Requesting frozen sperm or embryos is generally advisable wherever possible, in order to minimise the shipment of live mice.

  • Frozen embryos. Delivered in 4 weeks (after paperwork in place). €1740*
  • Rederivation of mice from frozen stock, delivery time available upon request . €3880*

Due to the dynamic nature of our processes strain availability may change at short notice. The local repository manager will advise you in these circumstances.

* In addition users have to cover all the shipping costs (including the cost for returning dry-shippers, where applicable).

More details on pricing and delivery times

Practical information

Genotyping protocol

Example health report
(Current health report will be provided later)

Material Transfer Agreement (MTA)
For this strain no provider MTA is needed. Distribution is based on the EMMA conditions only.

EMMA conditions
Legally binding conditions for the transfer

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