MGI phenotypes (allele matching)
- increased NK cell number / MGI
B6;129S5-Tnfsf15tm1Lex/Ieg
| Status | Available to order |
| EMMA ID | EM:02353 |
| International strain name | B6;129S5-Tnfsf15tm1Lex/Ieg |
| Alternative name | LEXKO-1554, MAS278N1 |
| Strain type | Targeted Mutant Strains : Knock-out |
| Allele/Transgene symbol | Tnfsf15tm1Lex |
| Gene/Transgene symbol | Tnfsf15 |
Information from provider
| Provider | Lexicon Genetics, Inc. |
| Provider affiliation | Lexicon Pharmaceuticals |
| Phenotypic information | The homozygous mutant mice exhibited an increased mean percentage of natural killer cells in peripheral blood when compared with that of their wild-type littermates and the historical means. |
| References | None available |
Information from EMMA
| Archiving centre | Helmholtz Zentrum Muenchen - German Research Center for Environmental Health (GmbH), Oberschleißheim, Germany |
| Animals used for archiving | heterozygous C57BL/6J, wild-type C57BL/6J |
| Stage of embryos | 2-cell |
Disease and phenotype information
MGI phenotypes (gene matching)
- decreased IgG level / MGI
- decreased susceptibility to induced arthritis / MGI
- decreased susceptibility to experimental autoimmune encephalomyelitis / MGI
- decreased B cell number / MGI
- decreased T cell number / MGI
- immune system phenotype / MGI
- increased NK cell number / MGI
- decreased plasma cell number / MGI
- lymph node hypoplasia / MGI
- abnormal dendritic cell differentiation / MGI
- decreased germinal center B cell number / MGI
- decreased IgG2a level / MGI
- decreased IgG2b level / MGI
- decreased T follicular helper cell number / MGI