IMPC phenotypes (gene matching)
B6;129S5-Il25tm1Lex/Orl
| Status | Available to order |
| EMMA ID | EM:02348 |
| International strain name | B6;129S5-Il25tm1Lex/Orl |
| Alternative name | LEXKO-0310 |
| Strain type | Targeted Mutant Strains : Knock-out |
| Allele/Transgene symbol | Il25tm1Lex |
| Gene/Transgene symbol | Il25 |
Information from provider
| Provider | Lexicon Genetics, Inc. |
| Provider affiliation | Lexicon Pharmaceuticals |
| Phenotypic information | The male homozygous mutant mice exhibited notably increased mean serum triglyceride levels when compared with their gender-matched wild-type littermates and the historical mean. No other notable phenotype was observed for the homozygous mutant mice. |
| References | None available |
Information from EMMA
| Archiving centre | Institut de Transgenose, INTRAGENE, Orléans, France |
Disease and phenotype information
MGI phenotypes (allele matching)
- increased circulating triglyceride level / MGI
MGI phenotypes (gene matching)
- abnormal crypts of Lieberkuhn morphology / MGI
- abnormal colon morphology / MGI
- increased circulating triglyceride level / MGI
- intestinal inflammation / MGI
- lung inflammation / MGI
- decreased susceptibility to bacterial infection / MGI
- increased IgE level / MGI
- no phenotypic analysis / MGI
- abnormal intestinal goblet cell morphology / MGI
- increased susceptibility to experimental autoimmune encephalomyelitis / MGI
- decreased eosinophil cell number / MGI
- increased T cell number / MGI
- abnormal response to infection / MGI
- increased susceptibility to parasitic infection / MGI
- abnormal mesenteric lymph node morphology / MGI
- increased susceptibility to type I hypersensitivity reaction / MGI
- decreased T-helper 2 cell number / MGI
- decreased IgG2a level / MGI
- decreased susceptibility to induced colitis / MGI
- decreased tumor necrosis factor secretion / MGI
- abnormal interleukin secretion / MGI
- decreased interleukin-1 beta secretion / MGI
- decreased interleukin-13 secretion / MGI
- decreased interleukin-4 secretion / MGI
- decreased interleukin-5 secretion / MGI
- decreased interleukin-9 secretion / MGI
- abnormal chemokine secretion / MGI
- abnormal interferon level / MGI
- abnormal interleukin level / MGI
- increased sensitivity to induced morbidity/mortality / MGI
- decreased susceptibility to weight loss / MGI