IMPC phenotypes (gene matching)
B6;129S5-Trib2tm1Lex/Orl
| Status | Available to order |
| EMMA ID | EM:02347 |
| International strain name | B6;129S5-Trib2tm1Lex/Orl |
| Alternative name | LEXKO-1136 |
| Strain type | Targeted Mutant Strains : Knock-out |
| Allele/Transgene symbol | Trib2tm1Lex |
| Gene/Transgene symbol | Trib2 |
Information from provider
| Provider | Lexicon Genetics, Inc. |
| Provider affiliation | Lexicon Pharmaceuticals |
| Phenotypic information | The homozygous mutant mice exhibited an increased mean percentage of CD8 cells and a decreased mean percentage of B cells in the peripheral blood when compared with their wild-type littermates and the historical means. The mutants also exhibited decreased exploratory activity during open field activity testing. |
| Breeding history | It seems the homozygous females are not very fertile and the best procedure is to cross homozygous males with heterozygous females. |
| References | None available |
Information from EMMA
| Archiving centre | Institut de Transgenose, INTRAGENE, Orléans, France |
Disease and phenotype information
MGI phenotypes (gene matching)
- tremors / MGI
- abnormal hippocampus morphology / MGI
- decreased body weight / MGI
- impaired coordination / MGI
- decreased exploration in new environment / MGI
- reduced long term potentiation / MGI
- abnormal posture / MGI
- limb grasping / MGI
- impaired righting response / MGI
- premature death / MGI
- no abnormal phenotype detected / MGI
- gliosis / MGI
- abnormal CNS synaptic transmission / MGI
- decreased vertical activity / MGI
- abnormal excitatory postsynaptic potential / MGI
- amyloid beta deposits / MGI
- astrocytosis / MGI
- abnormal behavior / MGI
- decreased B cell number / MGI
- hematopoietic system phenotype / MGI
- increased CD8-positive, alpha-beta T cell number / MGI
- abnormal hippocampus CA1 region morphology / MGI
- slow postnatal weight gain / MGI
- microgliosis / MGI
- decreased prepulse inhibition / MGI
- decreased hippocampus pyramidal cell number / MGI
- hippocampus pyramidal cell degeneration / MGI
- decreased food intake / MGI
- decreased fluid intake / MGI