B6;129S5-P2rx5tm1Lex/Ieg

Status

Available to order

EMMA IDEM:02345
International strain nameB6;129S5-P2rx5tm1Lex/Ieg
Alternative nameLEXKO-1615, CHA391N1
Strain typeTargeted Mutant Strains : Knock-out
Allele/Transgene symbolP2rx5tm1Lex
Gene/Transgene symbolP2rx5

Information from provider

Provider Lexicon Genetics, Inc.
Provider affiliationLexicon Pharmaceuticals
Phenotypic informationThe homozygous mutant mice exhibited decreased peripheral blood CD8+ lymphocytes and elevated NK cells. In addition, the mutants exhibited impaired learning/memory during trace aversive conditioning and increased exploratory behavior during open field testing.
ReferencesNone available

Information from EMMA

Archiving centreHelmholtz Zentrum Muenchen - German Research Center for Environmental Health (GmbH), Oberschleißheim, Germany

Disease and phenotype information

IMPC phenotypes (gene matching)
  • preweaning lethality, incomplete penetrance / IMPC
  • abnormal gait / IMPC
  • decreased exploration in new environment / IMPC
MGI phenotypes (allele matching)
  • increased exploration in new environment / MGI
  • increased NK cell number / MGI
  • decreased CD8-positive, alpha-beta T cell number / MGI
  • impaired cued conditioning behavior / MGI
MGI phenotypes (gene matching)
  • increased exploration in new environment / MGI
  • increased NK cell number / MGI
  • decreased CD8-positive, alpha-beta T cell number / MGI
  • impaired cued conditioning behavior / MGI

Information on how we integrate external resources can be found here

Order

Availabilities

Requesting frozen sperm or embryos is generally advisable wherever possible, in order to minimise the shipment of live mice.

  • Frozen embryos. Delivered in 4 weeks (after paperwork in place). €1740*
  • Rederivation of mice from frozen stock, delivery time available upon request . €3880*

Due to the dynamic nature of our processes strain availability may change at short notice. The local repository manager will advise you in these circumstances.

* In addition users have to cover all the shipping costs (including the cost for returning dry-shippers, where applicable).

More details on pricing and delivery times

Practical information

Genotyping protocol

Example health report
(Current health report will be provided later)

Material Transfer Agreement (MTA)
For this strain no provider MTA is needed. Distribution is based on the EMMA conditions only.

EMMA conditions
Legally binding conditions for the transfer

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