IMPC phenotypes (gene matching)
B6;129S5-Gria2tm1Lex/Ieg
| Status | Available to order |
| EMMA ID | EM:02336 |
| International strain name | B6;129S5-Gria2tm1Lex/Ieg |
| Alternative name | LEXKO-1605, CHA356C1 |
| Strain type | Targeted Mutant Strains : Knock-out |
| Allele/Transgene symbol | Gria2tm1Lex |
| Gene/Transgene symbol | Gria2 |
Information from provider
| Provider | Lexicon Genetics, Inc. |
| Provider affiliation | Lexicon Pharmaceuticals |
| Phenotypic information | The homozygous mutant mice exhibited numerous neurological abnormalities when compared with their wild-type littermates and the historical means, including an abnormal sleep/wake cycle, decreased exploratory and locomotor activity, and a motor strength deficit. |
| References | None available |
Information from EMMA
| Archiving centre | Helmholtz Zentrum Muenchen - German Research Center for Environmental Health (GmbH), Oberschleißheim, Germany |
Disease and phenotype information
MGI phenotypes (gene matching)
- hippocampal neuron degeneration / MGI
- abnormal spinal cord morphology / MGI
- decreased body weight / MGI
- decreased body size / MGI
- hyperactivity / MGI
- jumpy / MGI
- hypoactivity / MGI
- impaired coordination / MGI
- decreased exploration in new environment / MGI
- abnormal grooming behavior / MGI
- decreased grooming behavior / MGI
- postnatal growth retardation / MGI
- absent long term depression / MGI
- impaired synaptic plasticity / MGI
- abnormal reflex / MGI
- abnormal touch/ nociception / MGI
- seizures / MGI
- abnormal motor capabilities/coordination/movement / MGI
- premature death / MGI
- abnormal nervous system electrophysiology / MGI
- abnormal emotion/affect behavior / MGI
- abnormal nociception after inflammation / MGI
- abnormal AMPA-mediated synaptic currents / MGI
- abnormal excitatory postsynaptic potential / MGI
- enhanced long term potentiation / MGI
- no phenotypic analysis / MGI
- abnormal response to novel object / MGI
- nervous system phenotype / MGI
- tonic-clonic seizures / MGI
- abnormal limb posture / MGI
- lethargy / MGI
- hearing/vestibular/ear phenotype / MGI
- hyperalgesia / MGI
- abnormal cell physiology / MGI
- increased susceptibility to neuronal excitotoxicity / MGI
- abnormal hippocampus CA3 region morphology / MGI
- decreased chemical nociceptive threshold / MGI
- paraparesis / MGI
- decreased grip strength / MGI
- enhanced AMPA-mediated synaptic currents / MGI
- postnatal lethality, complete penetrance / MGI
- postnatal lethality, incomplete penetrance / MGI
- abnormal circadian sleep/wake cycle / MGI