IMPC phenotypes (gene matching)
B6;129S5-Rras2Gt(OST47398)Lex/Ieg
| Status | Available to order |
| EMMA ID | EM:02326 |
| International strain name | B6;129S5-Rras2Gt(OST47398)Lex/Ieg |
| Alternative name | LEXKO-648, RASTC21_1 |
| Strain type | Gene-trap |
| Allele/Transgene symbol | Rras2Gt(OST47398)Lex |
| Gene/Transgene symbol | Rras2 |
Information from provider
| Provider | Lexicon Genetics, Inc. |
| Provider affiliation | Lexicon Pharmaceuticals |
| Phenotypic information | Ophthalmic observations found reduced mean artery-to-vein ratio in the homozygous mutant mice as compared to wild-type littermates. In microscopic examination, homozygotes showed signs of retinal degeneration characterized by a reduction in thickness of external nuclear and photoreceptor layers as well as vacuolization of photoreceptor and external plexiorm layers. The male homozygotes also had a higher mean total tissue mass and mean total body fat as compared to the gender-matched wild-type littermates. RT-PCR analysis revealed that the transcript was absent in the homozygous mutant mice. |
| References | None available |
Information from EMMA
| Archiving centre | Helmholtz Zentrum Muenchen - German Research Center for Environmental Health (GmbH), Oberschleißheim, Germany |
Disease and phenotype information
Orphanet associated rare diseases, based on orthologous gene matching
- Noonan syndrome / Orphanet_648
MGI phenotypes (allele matching)
MGI phenotypes (gene matching)
- spleen hypoplasia / MGI
- increased body size / MGI
- retinal degeneration / MGI
- abnormal dendritic cell physiology / MGI
- abnormal B cell physiology / MGI
- abnormal retinal vasculature morphology / MGI
- maternal effect / MGI
- increased tumor growth/size / MGI
- abnormal retinal photoreceptor layer morphology / MGI
- abnormal retinal outer plexiform layer morphology / MGI
- abnormal CD8-positive, alpha-beta T cell physiology / MGI
- decreased spleen weight / MGI
- decreased B cell number / MGI
- decreased T cell number / MGI
- decreased B cell proliferation / MGI
- immune system phenotype / MGI
- abnormal dendritic cell morphology / MGI
- abnormal CD4-positive, alpha-beta T cell physiology / MGI
- decreased memory T cell number / MGI
- decreased follicular B cell number / MGI
- decreased marginal zone B cell number / MGI
- abnormal B cell activation / MGI
- abnormal spleen B cell follicle morphology / MGI
- thin retinal outer nuclear layer / MGI
- abnormal lymph node germinal center morphology / MGI
- increased total body fat amount / MGI