B6;129S5-RrasGt(OST24882)Lex/Ieg

Status

Available to order

EMMA IDEM:02325
International strain nameB6;129S5-RrasGt(OST24882)Lex/Ieg
Alternative nameLEXKO-692, SGT212T1
Strain typeGene-trap
Allele/Transgene symbolRrasGt(OST24882)Lex
Gene/Transgene symbolRras

Information from provider

Provider Lexicon Genetics, Inc.
Provider affiliationLexicon Pharmaceuticals
Phenotypic informationThe homozygous mutant mice exhibited increased mean percentages of both CD4 and CD8 cells and a decreased mean percentage of B cells when compared to their wild-type littermates and the historical means. RT-PCR analysis revealed that the transcript was absent in the homozygous mutant mice.
ReferencesNone available

Information from EMMA

Archiving centreHelmholtz Zentrum Muenchen - German Research Center for Environmental Health (GmbH), Oberschleißheim, Germany

Disease and phenotype information

IMPC phenotypes (gene matching)
  • decreased fasting circulating glucose level / IMPC
  • increased circulating triglyceride level / IMPC
  • increased circulating serum albumin level / IMPC
  • decreased circulating calcium level / IMPC
  • increased grip strength / IMPC
MGI phenotypes (allele matching)
  • decreased B cell number / MGI
  • increased CD4-positive, alpha beta T cell number / MGI
  • increased CD8-positive, alpha-beta T cell number / MGI
  • abnormal physiological neovascularization / MGI
  • abnormal vascular wound healing / MGI
  • artery stenosis / MGI
  • abnormal tumor vascularization / MGI
MGI phenotypes (gene matching)
  • abnormal physiological neovascularization / MGI
  • abnormal vascular wound healing / MGI
  • decreased B cell number / MGI
  • artery stenosis / MGI
  • increased CD4-positive, alpha beta T cell number / MGI
  • increased CD8-positive, alpha-beta T cell number / MGI
  • abnormal tumor vascularization / MGI

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Order

Availabilities

Requesting frozen sperm or embryos is generally advisable wherever possible, in order to minimise the shipment of live mice.

  • Frozen embryos. Delivered in 4 weeks (after paperwork in place). €1740*
  • Rederivation of mice from frozen stock, delivery time available upon request . €3880*

Due to the dynamic nature of our processes strain availability may change at short notice. The local repository manager will advise you in these circumstances.

* In addition users have to cover all the shipping costs (including the cost for returning dry-shippers, where applicable).

More details on pricing and delivery times

Practical information

Genotyping protocol

Example health report
(Current health report will be provided later)

Material Transfer Agreement (MTA)
For this strain no provider MTA is needed. Distribution is based on the EMMA conditions only.

EMMA conditions
Legally binding conditions for the transfer

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