B6;129S5-MrasGt(OST108223)Lex/Ieg

Status

Available to order

EMMA IDEM:02322
International strain nameB6;129S5-MrasGt(OST108223)Lex/Ieg
Alternative nameLEXKO-435, MRAS_1
Strain typeGene-trap
Allele/Transgene symbolMrasGt(OST108223)Lex
Gene/Transgene symbolMras

Information from provider

Provider Lexicon Genetics, Inc.
Provider affiliationLexicon Pharmaceuticals
Phenotypic informationMutation resulted in a decreased mean percentage of peripheral blood B cells in the homozygous mutant mice, as compared to their wild-type (+/+) littermates and historical means. Northern hybridization analysis revealed that the transcript was absent in the homozygous mutant mice.
ReferencesNone available

Information from EMMA

Archiving centreHelmholtz Zentrum Muenchen - German Research Center for Environmental Health (GmbH), Oberschleißheim, Germany

Disease and phenotype information

Orphanet associated rare diseases, based on orthologous gene matching

IMPC phenotypes (gene matching)
  • decreased locomotor activity / IMPC
  • decreased total body fat amount / IMPC
  • increased anxiety-related response / IMPC
  • increased thigmotaxis / IMPC
  • increased lean body mass / IMPC
  • abnormal behavior / IMPC
  • decreased exploration in new environment / IMPC
  • increased circulating creatinine level / IMPC
MGI phenotypes (allele matching)
  • decreased B cell number / MGI
MGI phenotypes (gene matching)
  • no abnormal phenotype detected / MGI
  • decreased B cell number / MGI

Information on how we integrate external resources can be found here

Order

Availabilities

Requesting frozen sperm or embryos is generally advisable wherever possible, in order to minimise the shipment of live mice.

  • Frozen embryos. Delivered in 4 weeks (after paperwork in place). €1740*
  • Rederivation of mice from frozen stock, delivery time available upon request . €3880*

Due to the dynamic nature of our processes strain availability may change at short notice. The local repository manager will advise you in these circumstances.

* In addition users have to cover all the shipping costs (including the cost for returning dry-shippers, where applicable).

More details on pricing and delivery times

Practical information

Genotyping protocol

Example health report
(Current health report will be provided later)

Material Transfer Agreement (MTA)
For this strain no provider MTA is needed. Distribution is based on the EMMA conditions only.

EMMA conditions
Legally binding conditions for the transfer

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