B6;129S5-Igf1rtm1Lex/Ieg

Status

Available to order

EMMA IDEM:02317
International strain nameB6;129S5-Igf1rtm1Lex/Ieg
Alternative nameLEXKO-322, MEM490C1
Strain typeTargeted Mutant Strains : Knock-out
Allele/Transgene symbolIgf1rtm1Lex
Gene/Transgene symbolIgf1r

Information from provider

Provider Lexicon Genetics, Inc.
Provider affiliationLexicon Pharmaceuticals
Phenotypic informationGenetic data indicate that this mutation resulted in lethality of the homozygous mutants. No notable phenotype was observed for the heterozygous mice. Disruption of the target gene was confirmed by Southern hybridization analysis.
ReferencesNone available

Information from EMMA

Archiving centreHelmholtz Zentrum Muenchen - German Research Center for Environmental Health (GmbH), Oberschleißheim, Germany

Disease and phenotype information

Orphanet associated rare diseases, based on orthologous gene matching

    • Growth delay due to insulin-like growth factor I resistance / Orphanet_73273
MGI phenotypes (gene matching)
  • abnormal cochlea morphology / MGI
  • abnormal lateral semicircular canal morphology / MGI
  • delayed bone ossification / MGI
  • abnormal hair follicle morphology / MGI
  • decreased hair follicle number / MGI
  • small hair follicles / MGI
  • abnormal liver morphology / MGI
  • muscle hypoplasia / MGI
  • decreased oligodendrocyte progenitor number / MGI
  • abnormal spinal cord morphology / MGI
  • atelectasis / MGI
  • translucent skin / MGI
  • thin epidermis / MGI
  • thin epidermis stratum spinosum / MGI
  • decreased body weight / MGI
  • cyanosis / MGI
  • postnatal growth retardation / MGI
  • respiratory failure / MGI
  • abnormal postnatal growth/weight/body size / MGI
  • abnormal muscle morphology / MGI
  • hydrops fetalis / MGI
  • abnormal semicircular canal morphology / MGI
  • abnormal posterior semicircular canal morphology / MGI
  • abnormal cochlear sensory epithelium morphology / MGI
  • abnormal bony labyrinth / MGI
  • abnormal cochlear inner hair cell morphology / MGI
  • decreased cochlear inner hair cell number / MGI
  • abnormal cochlear outer hair cell morphology / MGI
  • decreased cochlear outer hair cell number / MGI
  • decreased cochlear hair cell number / MGI
  • abnormal cochlear hair cell stereociliary bundle morphology / MGI
  • abnormal cochlear hair cell development / MGI
  • abnormal brainstem morphology / MGI
  • homeostasis/metabolism phenotype / MGI
  • growth/size/body region phenotype / MGI
  • decreased birth weight / MGI
  • prenatal growth retardation / MGI
  • abnormal inner hair cell kinocilium morphology / MGI
  • neonatal lethality, complete penetrance / MGI

Information on how we integrate external resources can be found here

Order

Availabilities

Requesting frozen sperm or embryos is generally advisable wherever possible, in order to minimise the shipment of live mice.

  • Frozen embryos. Delivered in 4 weeks (after paperwork in place). €1740*
  • Rederivation of mice from frozen stock, delivery time available upon request . €3880*

Due to the dynamic nature of our processes strain availability may change at short notice. The local repository manager will advise you in these circumstances.

* In addition users have to cover all the shipping costs (including the cost for returning dry-shippers, where applicable).

More details on pricing and delivery times

Practical information

Genotyping protocol

Example health report
(Current health report will be provided later)

Material Transfer Agreement (MTA)
For this strain no provider MTA is needed. Distribution is based on the EMMA conditions only.

EMMA conditions
Legally binding conditions for the transfer

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