B6;129S5-Elovl6Gt(OST222498)Lex/Orl

Status

Available to order

EMMA IDEM:02313
International strain nameB6;129S5-Elovl6Gt(OST222498)Lex/Orl
Alternative nameLEXKO-129
Strain typeGene-trap
Allele/Transgene symbolElovl6Gt(OST222498)Lex
Gene/Transgene symbolElovl6

Information from provider

Provider Lexicon Genetics, Inc.
Provider affiliationLexicon Pharmaceuticals
Phenotypic informationNeurological data suggest enhanced motor coordination in the homozygous mutant mice. Serum cholesterol levels were reduced in female (-/-) mice. RT-PCR analysis revealed that the transcript was absent in the homozygous mutant mice.
ReferencesNone available

Information from EMMA

Archiving centreInstitut de Transgenose, INTRAGENE, Orléans, France

Disease and phenotype information

IMPC phenotypes (gene matching)
  • increased circulating alkaline phosphatase level / IMPC
  • limb grasping / IMPC
  • increased circulating triglyceride level / IMPC
  • increased red blood cell distribution width / IMPC
  • preweaning lethality, incomplete penetrance / IMPC
  • increased circulating amylase level / IMPC
  • decreased exploration in new environment / IMPC
MGI phenotypes (allele matching)
  • enhanced coordination / MGI
  • decreased circulating cholesterol level / MGI
  • abnormal liver morphology / MGI
  • abnormal lipid homeostasis / MGI
  • hepatic steatosis / MGI
  • decreased circulating insulin level / MGI
  • increased insulin sensitivity / MGI
  • increased lean body mass / MGI
  • abnormal pancreatic islet morphology / MGI
  • abnormal fatty acid level / MGI
  • improved glucose tolerance / MGI
  • growth/size/body region phenotype / MGI
  • decreased circulating leptin level / MGI
  • abnormal hepatocyte physiology / MGI
  • embryonic lethality, incomplete penetrance / MGI
  • decreased fatty acid oxidation / MGI
MGI phenotypes (gene matching)
  • abnormal liver morphology / MGI
  • abnormal lipid homeostasis / MGI
  • hepatic steatosis / MGI
  • decreased circulating insulin level / MGI
  • increased insulin sensitivity / MGI
  • enhanced coordination / MGI
  • increased lean body mass / MGI
  • decreased circulating cholesterol level / MGI
  • abnormal pancreatic islet morphology / MGI
  • abnormal fatty acid level / MGI
  • improved glucose tolerance / MGI
  • growth/size/body region phenotype / MGI
  • decreased circulating leptin level / MGI
  • abnormal hepatocyte physiology / MGI
  • embryonic lethality, incomplete penetrance / MGI
  • decreased fatty acid oxidation / MGI

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Availabilities

Requesting frozen sperm or embryos is generally advisable wherever possible, in order to minimise the shipment of live mice.

Due to the dynamic nature of our processes strain availability may change at short notice. The local repository manager will advise you in these circumstances.

* In addition users have to cover all the shipping costs (including the cost for returning dry-shippers, where applicable).

More details on pricing and delivery times

Practical information

Genotyping protocol

Example health report
(Current health report will be provided later)

Material Transfer Agreement (MTA)
For this strain no provider MTA is needed. Distribution is based on the EMMA conditions only.

EMMA conditions
Legally binding conditions for the transfer

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