- tremors / MGI
- forelimb paralysis / MGI
- abnormal cerebellar granule layer morphology / MGI
- abnormal retinal photoreceptor morphology / MGI
- retinal degeneration / MGI
- impaired coordination / MGI
- impaired righting response / MGI
- nervous system phenotype / MGI
- eyelids fail to open / MGI
- abnormal brainstem morphology / MGI
- vision/eye phenotype / MGI
- abnormal food intake / MGI
- retinal photoreceptor degeneration / MGI
- thin retinal outer nuclear layer / MGI
- retinal outer nuclear layer degeneration / MGI
- enlarged lateral ventricles / MGI
- enlarged third ventricle / MGI
- short photoreceptor inner segment / MGI
- short photoreceptor outer segment / MGI
- postnatal lethality, complete penetrance / MGI
B6.129S2-Atp1b2tm1Msch/Cnrm
Status | Available to order |
EMMA ID | EM:00023 |
International strain name | B6.129S2-Atp1b2tm1Msch/Cnrm |
Alternative name | AMOG-KO |
Strain type | Targeted Mutant Strains : Knock-out |
Allele/Transgene symbol | Atp1b2tm1Msch |
Gene/Transgene symbol | Atp1b2 |
Information from provider
Provider | Melitta Schachner |
Provider affiliation | Center for molecular neurobiology Hamburg, Center for molecular neurobiology Hamburg |
Genetic information | The neo gene was inserted into the first exon of the Atp1b2 (AMOG/2) genomic clone G7sH resulting in two in-frame stop codons. |
Phenotypic information | Homozygous animals die 17-18 d after birth. They display motor uncoordination at 15 d of age. Pathological traits of the nervous system (17-18 d after birth): enlarged ventricles, degenerating photoreceptor cells, swelling and degeneration of astrocytic endfeet in brain stem. |
Breeding history | Backcrossed to C57BL/6 (more than 5 generations). |
References |
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Information from EMMA
Archiving centre | CNR, Consiglio Nazionale delle Ricerche, Monterotondo, Italy |
Animals used for archiving | heterozygous C57BL/6, wild-type C57BL/6 |
Stage of embryos | 2-cell |
Disease and phenotype information
MGI phenotypes (allele matching)
MGI phenotypes (gene matching)
- tremors / MGI
- forelimb paralysis / MGI
- abnormal cerebellar granule layer morphology / MGI
- abnormal retinal photoreceptor morphology / MGI
- retinal degeneration / MGI
- impaired coordination / MGI
- impaired righting response / MGI
- nervous system phenotype / MGI
- eyelids fail to open / MGI
- abnormal brainstem morphology / MGI
- vision/eye phenotype / MGI
- abnormal food intake / MGI
- abnormal retinal neuronal layer morphology / MGI
- retinal photoreceptor degeneration / MGI
- thin retinal outer nuclear layer / MGI
- retinal outer nuclear layer degeneration / MGI
- enlarged lateral ventricles / MGI
- enlarged third ventricle / MGI
- short photoreceptor inner segment / MGI
- short photoreceptor outer segment / MGI
- postnatal lethality, complete penetrance / MGI
- increased retinal apoptosis / MGI
Literature references
- Degeneration of neural cells in the central nervous system of mice deficient in the gene for the adhesion molecule on Glia, the beta 2 subunit of murine Na,K-ATPase.;Magyar J P, Bartsch U, Wang Z Q, Howells N, Aguzzi A, Wagner E F, Schachner M, ;1994;The Journal of cell biology;127;835-45; 7525597
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