MGI phenotypes (allele matching)
B6;129P2-Mc2rtm1Dgen/H
| Status | Available to order |
| EMMA ID | EM:02299 |
| International strain name | B6;129P2-Mc2rtm1Dgen/H |
| Alternative name | DELTAGEN_T605 |
| Strain type | Targeted Mutant Strains : Knock-out |
| Allele/Transgene symbol | Mc2rtm1Dgen |
| Gene/Transgene symbol | Mc2r |
Information from provider
| Provider | Deltagen Inc. |
| Provider affiliation | Deltagen Inc. |
| Phenotypic information | Histopathology: Adrenal gland, hypoplasia (cortex and medulla); Brown adipose tissue, decreased cytoplasmic lipid vacuolation. Densitometry : Low fat % in homozygous mutant females. Behavior: Decreased metrazol response threshold; Increased total distance traveled in open field test; Decreased time immobile on tail suspension test. Changes related to genotype at 300 days: Histopathology : Adrenal gland, hypoplasia (cortex); Brown adipose tissue, decreased cytoplasmic lipid vacuolation. Densitometry : Low fat % in homozygous mutant females. |
| References | None available |
Information from EMMA
| Archiving centre | Mary Lyon Centre at MRC Harwell, Oxford, United Kingdom |
| Animals used for archiving | heterozygous C57BL/6J |
| Stage of embryos | 2-cell |
Disease and phenotype information
Orphanet associated rare diseases, based on orthologous gene matching
- Familial glucocorticoid deficiency / Orphanet_361
MGI phenotypes (gene matching)
- hypoglycemia / MGI
- adrenal gland hypoplasia / MGI
- increased anxiety-related response / MGI
- hyperactivity / MGI
- increased circulating adrenocorticotropin level / MGI
- abnormal glucose homeostasis / MGI
- decreased circulating corticosterone level / MGI
- decreased circulating aldosterone level / MGI
- increased susceptibility to pharmacologically induced seizures / MGI
- increased circulating chloride level / MGI
- abnormal gluconeogenesis / MGI
- increased spleen weight / MGI
- increased thymus weight / MGI
- lethargy / MGI
- decreased heart rate / MGI
- decreased percent body fat/body weight / MGI
- increased circulating potassium level / MGI
- decreased circulating adrenaline level / MGI
- abnormal adrenal gland zona fasciculata morphology / MGI
- adrenal cortical hyperplasia / MGI
- decreased brown fat lipid droplet number / MGI
- decreased total body fat amount / MGI
- postnatal lethality, incomplete penetrance / MGI
- abnormal adrenal gland capsule morphology / MGI