MGI phenotypes (allele matching)
B6;129P2-Mc2rtm1Dgen/H
| Status | Available to order |
| EMMA ID | EM:02299 |
| Citation information | RRID:IMSR_EM:02299 Research Resource Identifiers (RRID) are persistent unique ID numbers assigned to help researchers cite key resources (e.g. antibodies, model organisms and software projects) in the biomedical literature to improve transparency and reproducibility in research. See https://www.rrids.org/ for more information. |
| International strain name | B6;129P2-Mc2rtm1Dgen/H |
| Alternative name | DELTAGEN_T605 |
| Strain type | Targeted Mutant Strains : Knock-out |
| Allele/Transgene symbol | Mc2rtm1Dgen |
| Gene/Transgene symbol | Mc2r |
Information from provider
| Provider | Deltagen Inc. |
| Provider affiliation | Deltagen Inc. |
| Phenotypic information | Histopathology: Adrenal gland, hypoplasia (cortex and medulla); Brown adipose tissue, decreased cytoplasmic lipid vacuolation. Densitometry : Low fat % in homozygous mutant females. Behavior: Decreased metrazol response threshold; Increased total distance traveled in open field test; Decreased time immobile on tail suspension test. Changes related to genotype at 300 days: Histopathology : Adrenal gland, hypoplasia (cortex); Brown adipose tissue, decreased cytoplasmic lipid vacuolation. Densitometry : Low fat % in homozygous mutant females. |
| References | None available |
Information from EMMA
| Archiving centre | Mary Lyon Centre at MRC Harwell, Oxford, United Kingdom |
| Animals used for archiving | heterozygous C57BL/6J males |
| Stage of embryos | 2-cell |
Disease and phenotype information
Orphanet associated rare diseases, based on orthologous gene matching
- Familial glucocorticoid deficiency / Orphanet_361
MGI phenotypes (gene matching)
- hypoglycemia / MGI
- adrenal gland hypoplasia / MGI
- increased anxiety-related response / MGI
- hyperactivity / MGI
- increased circulating adrenocorticotropin level / MGI
- abnormal glucose homeostasis / MGI
- decreased circulating corticosterone level / MGI
- decreased circulating aldosterone level / MGI
- increased susceptibility to pharmacologically induced seizures / MGI
- increased circulating chloride level / MGI
- abnormal gluconeogenesis / MGI
- increased spleen weight / MGI
- increased thymus weight / MGI
- lethargy / MGI
- decreased heart rate / MGI
- decreased percent body fat/body weight / MGI
- increased circulating potassium level / MGI
- decreased circulating adrenaline level / MGI
- abnormal adrenal gland zona fasciculata morphology / MGI
- adrenal cortical hyperplasia / MGI
- decreased brown fat lipid droplet number / MGI
- decreased total body fat amount / MGI
- postnatal lethality, incomplete penetrance / MGI
- abnormal adrenal gland capsule morphology / MGI